Basifungin

DB14058

small molecule experimental

Deskripsi

Basifungin, also known as aureuobacidin A, is a phosphorylceramide synthase inhibitor ^L2960, ^A33381.

Struktur Molekul 2D

Berat 1085.442

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) -

Volume Distribusi -

Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

14 Data

Dicoumarol	The therapeutic efficacy of Dicoumarol can be increased when used in combination with Basifungin.
Phenindione	The therapeutic efficacy of Phenindione can be increased when used in combination with Basifungin.
Warfarin	The therapeutic efficacy of Warfarin can be increased when used in combination with Basifungin.
Phenprocoumon	The therapeutic efficacy of Phenprocoumon can be increased when used in combination with Basifungin.
Acenocoumarol	The therapeutic efficacy of Acenocoumarol can be increased when used in combination with Basifungin.
4-hydroxycoumarin	The therapeutic efficacy of 4-hydroxycoumarin can be increased when used in combination with Basifungin.
Coumarin	The therapeutic efficacy of Coumarin can be increased when used in combination with Basifungin.
(R)-warfarin	The therapeutic efficacy of (R)-warfarin can be increased when used in combination with Basifungin.
Ethyl biscoumacetate	The therapeutic efficacy of Ethyl biscoumacetate can be increased when used in combination with Basifungin.
Fluindione	The therapeutic efficacy of Fluindione can be increased when used in combination with Basifungin.
Clorindione	The therapeutic efficacy of Clorindione can be increased when used in combination with Basifungin.
Diphenadione	The therapeutic efficacy of Diphenadione can be increased when used in combination with Basifungin.
Tioclomarol	The therapeutic efficacy of Tioclomarol can be increased when used in combination with Basifungin.
(S)-Warfarin	The therapeutic efficacy of (S)-Warfarin can be increased when used in combination with Basifungin.

Target Protein

Inositol phosphorylceramide synthase AUR1

Referensi & Sumber

Artikel (PubMed)

PMID: 19047657
Aeed PA, Young CL, Nagiec MM, Elhammer AP: Inhibition of inositol phosphorylceramide synthase by the cyclic peptide aureobasidin A. Antimicrob Agents Chemother. 2009 Feb;53(2):496-504. doi: 10.1128/AAC.00633-08. Epub 2008 Dec 1.

Link

Contoh Produk & Brand

Produk: 0 • International brands: 0

Belum ada data produk/brand untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field produk/brand.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.