Peringatan Keamanan

In overdose, bromotheophylline does not produce hepatic toxicity.L2743

Bromotheophylline

DB14018

small molecule approved

Deskripsi

Bromotheophylline is the active moiety of pamabrom, a mixture of 2-amino-2-methyl-propanol and bromotheophylline. From this mixture, bromotheophylline acts as a weak diuretic that has been used along with some analgesics to relieve the symptoms of premenstrual syndrome.A33018 Bromotheophylline is categorized on the FDA as a drug substance with an inactive state since March, 1980.L1082 It is also approved by Health Canada to be used alone or in combination with DB00316 in OTC products.L1113

Struktur Molekul 2D

Berat 259.063
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The apparent elimination half-life is registered to be 21.35 hours.[L2743]
Volume Distribusi This pharmacokinetic property has not been determined.
Klirens (Clearance) This pharmacokinetic property has not been determined.

Absorpsi

When administered after one single oral dosage, bromotheophylline is rapidly absorbed and it reaches a maximal plasma concentration of 2.5 mg/L in 0.78 hours. The mean residence time is registered to be of 12 hours with an AUC in the first 8 hours of 27 mg.h/L.L2742

Metabolisme

This pharmacokinetic property has not been determined.

Rute Eliminasi

This pharmacokinetic property has not been determined.

Interaksi Makanan

2 Data
  • 1. Drink plenty of fluids. Avoid dehydration by drinking 6-8 glasses of water daily.
  • 2. Take with a full glass of water.

Interaksi Obat

1114 Data
Deferasirox The serum concentration of Bromotheophylline can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of Bromotheophylline can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Bromotheophylline can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Bromotheophylline can be decreased when it is combined with Teriflunomide.
Regadenoson Bromotheophylline may decrease effectiveness of Regadenoson as a diagnostic agent.
Adalimumab The serum concentration of Bromotheophylline can be decreased when it is combined with Adalimumab.
Adenosine The therapeutic efficacy of Adenosine can be decreased when used in combination with Bromotheophylline.
Allopurinol The serum concentration of Bromotheophylline can be increased when it is combined with Allopurinol.
Carbamazepine The serum concentration of Bromotheophylline can be decreased when it is combined with Carbamazepine.
Cimetidine The metabolism of Bromotheophylline can be decreased when combined with Cimetidine.
Disulfiram The serum concentration of Bromotheophylline can be increased when it is combined with Disulfiram.
Febuxostat The serum concentration of the active metabolites of Bromotheophylline can be increased when Bromotheophylline is used in combination with Febuxostat.
Fluvoxamine The metabolism of Bromotheophylline can be decreased when combined with Fluvoxamine.
Formoterol The risk or severity of hypokalemia can be increased when Bromotheophylline is combined with Formoterol.
Indacaterol The risk or severity of adverse effects can be increased when Bromotheophylline is combined with Indacaterol.
Isoniazid The serum concentration of Bromotheophylline can be increased when it is combined with Isoniazid.
Lithium citrate The serum concentration of Lithium citrate can be decreased when it is combined with Bromotheophylline.
Lithium carbonate The serum concentration of Lithium carbonate can be decreased when it is combined with Bromotheophylline.
Lithium hydroxide The serum concentration of Lithium hydroxide can be decreased when it is combined with Bromotheophylline.
Mexiletine The metabolism of Bromotheophylline can be decreased when combined with Mexiletine.
Olodaterol Bromotheophylline may increase the hyperkalemic activities of Olodaterol.
Pancuronium The therapeutic efficacy of Pancuronium can be decreased when used in combination with Bromotheophylline.
Pentoxifylline The serum concentration of Bromotheophylline can be increased when it is combined with Pentoxifylline.
Phenytoin The serum concentration of Bromotheophylline can be decreased when it is combined with Phenytoin.
Fosphenytoin The serum concentration of Bromotheophylline can be decreased when it is combined with Fosphenytoin.
Propafenone The serum concentration of Bromotheophylline can be increased when it is combined with Propafenone.
Quinine The serum concentration of Bromotheophylline can be increased when it is combined with Quinine.
Quinidine The serum concentration of Bromotheophylline can be increased when it is combined with Quinidine.
Riociguat Bromotheophylline may increase the hypotensive activities of Riociguat.
Thiabendazole The metabolism of Bromotheophylline can be decreased when combined with Thiabendazole.
Ticlopidine The metabolism of Bromotheophylline can be decreased when combined with Ticlopidine.
Zafirlukast The serum concentration of Zafirlukast can be decreased when it is combined with Bromotheophylline.
Probenecid The serum concentration of Bromotheophylline can be increased when it is combined with Probenecid.
Abiraterone The serum concentration of Bromotheophylline can be increased when it is combined with Abiraterone.
Isoprenaline The serum concentration of Bromotheophylline can be decreased when it is combined with Isoprenaline.
Cyproterone acetate The metabolism of Bromotheophylline can be increased when combined with Cyproterone acetate.
Amphetamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Bromotheophylline.
Phentermine The risk or severity of adverse effects can be increased when Phentermine is combined with Bromotheophylline.
Midodrine The risk or severity of adverse effects can be increased when Midodrine is combined with Bromotheophylline.
Norepinephrine The risk or severity of adverse effects can be increased when Norepinephrine is combined with Bromotheophylline.
Phenylephrine The risk or severity of adverse effects can be increased when Phenylephrine is combined with Bromotheophylline.
Phenylpropanolamine The risk or severity of adverse effects can be increased when Phenylpropanolamine is combined with Bromotheophylline.
Labetalol The risk or severity of adverse effects can be increased when Labetalol is combined with Bromotheophylline.
Metaraminol The risk or severity of adverse effects can be increased when Metaraminol is combined with Bromotheophylline.
Epinephrine The risk or severity of adverse effects can be increased when Epinephrine is combined with Bromotheophylline.
Methoxamine The risk or severity of adverse effects can be increased when Methoxamine is combined with Bromotheophylline.
Orciprenaline The risk or severity of adverse effects can be increased when Orciprenaline is combined with Bromotheophylline.
Phenmetrazine The risk or severity of adverse effects can be increased when Phenmetrazine is combined with Bromotheophylline.
Dobutamine The risk or severity of adverse effects can be increased when Dobutamine is combined with Bromotheophylline.
Pseudoephedrine The risk or severity of adverse effects can be increased when Pseudoephedrine is combined with Bromotheophylline.
Benzphetamine The risk or severity of adverse effects can be increased when Benzphetamine is combined with Bromotheophylline.
Ritodrine The risk or severity of adverse effects can be increased when Ritodrine is combined with Bromotheophylline.
Terbutaline The risk or severity of adverse effects can be increased when Terbutaline is combined with Bromotheophylline.
Oxymetazoline The risk or severity of adverse effects can be increased when Oxymetazoline is combined with Bromotheophylline.
Diethylpropion The risk or severity of adverse effects can be increased when Diethylpropion is combined with Bromotheophylline.
Dopamine The risk or severity of adverse effects can be increased when Dopamine is combined with Bromotheophylline.
Acebutolol The risk or severity of adverse effects can be increased when Acebutolol is combined with Bromotheophylline.
Lisdexamfetamine The risk or severity of adverse effects can be increased when Lisdexamfetamine is combined with Bromotheophylline.
Fenoterol The risk or severity of adverse effects can be increased when Fenoterol is combined with Bromotheophylline.
Ephedrine The risk or severity of adverse effects can be increased when Ephedrine is combined with Bromotheophylline.
Mephentermine The risk or severity of adverse effects can be increased when Mephentermine is combined with Bromotheophylline.
Procaterol The risk or severity of adverse effects can be increased when Procaterol is combined with Bromotheophylline.
Clenbuterol The risk or severity of adverse effects can be increased when Clenbuterol is combined with Bromotheophylline.
MMDA The risk or severity of adverse effects can be increased when MMDA is combined with Bromotheophylline.
Midomafetamine The risk or severity of adverse effects can be increased when Midomafetamine is combined with Bromotheophylline.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of adverse effects can be increased when 2,5-Dimethoxy-4-ethylamphetamine is combined with Bromotheophylline.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of adverse effects can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with Bromotheophylline.
Tenamfetamine The risk or severity of adverse effects can be increased when Tenamfetamine is combined with Bromotheophylline.
Chlorphentermine The risk or severity of adverse effects can be increased when Chlorphentermine is combined with Bromotheophylline.
Methylenedioxyethamphetamine The risk or severity of adverse effects can be increased when Methylenedioxyethamphetamine is combined with Bromotheophylline.
Dextroamphetamine The risk or severity of adverse effects can be increased when Dextroamphetamine is combined with Bromotheophylline.
Metamfetamine The risk or severity of adverse effects can be increased when Metamfetamine is combined with Bromotheophylline.
Celiprolol The risk or severity of adverse effects can be increased when Celiprolol is combined with Bromotheophylline.
Nylidrin The risk or severity of adverse effects can be increased when Nylidrin is combined with Bromotheophylline.
Tetryzoline The risk or severity of adverse effects can be increased when Tetryzoline is combined with Bromotheophylline.
Tyramine The risk or severity of adverse effects can be increased when Tyramine is combined with Bromotheophylline.
Isoxsuprine The risk or severity of adverse effects can be increased when Isoxsuprine is combined with Bromotheophylline.
Etilefrine The risk or severity of adverse effects can be increased when Etilefrine is combined with Bromotheophylline.
Synephrine The risk or severity of adverse effects can be increased when Synephrine is combined with Bromotheophylline.
Hydroxyamphetamine The risk or severity of adverse effects can be increased when Hydroxyamphetamine is combined with Bromotheophylline.
Iofetamine I-123 The risk or severity of adverse effects can be increased when Iofetamine I-123 is combined with Bromotheophylline.
Racepinephrine The risk or severity of adverse effects can be increased when Racepinephrine is combined with Bromotheophylline.
Ritobegron The risk or severity of adverse effects can be increased when Ritobegron is combined with Bromotheophylline.
Bucindolol The risk or severity of adverse effects can be increased when Bucindolol is combined with Bromotheophylline.
Tramazoline The risk or severity of adverse effects can be increased when Tramazoline is combined with Bromotheophylline.
Mephedrone The risk or severity of adverse effects can be increased when Mephedrone is combined with Bromotheophylline.
Fenozolone The risk or severity of adverse effects can be increased when Fenozolone is combined with Bromotheophylline.
Methoxyphenamine The risk or severity of adverse effects can be increased when Methoxyphenamine is combined with Bromotheophylline.
Tretoquinol The risk or severity of adverse effects can be increased when Tretoquinol is combined with Bromotheophylline.
Gepefrine The risk or severity of adverse effects can be increased when Gepefrine is combined with Bromotheophylline.
Epanolol The risk or severity of adverse effects can be increased when Epanolol is combined with Bromotheophylline.
Prenalterol The risk or severity of adverse effects can be increased when Prenalterol is combined with Bromotheophylline.
Mefenorex The risk or severity of adverse effects can be increased when Mefenorex is combined with Bromotheophylline.
2,5-Dimethoxy-4-ethylthioamphetamine The risk or severity of adverse effects can be increased when 2,5-Dimethoxy-4-ethylthioamphetamine is combined with Bromotheophylline.
Esmolol The risk or severity of adverse effects can be increased when Esmolol is combined with Bromotheophylline.
Betaxolol The risk or severity of adverse effects can be increased when Betaxolol is combined with Bromotheophylline.
Metoprolol The risk or severity of adverse effects can be increased when Metoprolol is combined with Bromotheophylline.
Atenolol The risk or severity of adverse effects can be increased when Atenolol is combined with Bromotheophylline.
Timolol The risk or severity of adverse effects can be increased when Timolol is combined with Bromotheophylline.
Sotalol The risk or severity of adverse effects can be increased when Sotalol is combined with Bromotheophylline.

Target Protein

Adenosine receptor ADORA1

Referensi & Sumber

Artikel (PubMed)
  • PMID: 25035530
    Shah U, Kavad M, Raval M: Development and Validation of Stability-indicating RP-HPLC Method for Estimation of Pamabrom in Tablets. Indian J Pharm Sci. 2014 May;76(3):198-202.
  • PMID: 13583790
    MUDGE GH, WEINER IM: The mechanism of action of mercurial and xanthine diuretics. Ann N Y Acad Sci. 1958 Feb 3;71(4):344-54.

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