Peringatan Keamanan

Some toxicity has been reported related to administration of pentetic acid including depletion of trace metals, kidney and liver vacuolization and small bowel hemorrhage lesions.A32508

Pentetic acid

DB14007

small molecule approved

Deskripsi

Pentetic acid, also known as diethylenetriaminepentaacetic acid (DTPA), is a synthetic polyamino carboxylic acid with eight coordinate bond forming sites that can sequester metal ions and form highly stable DTPA-metal ion complexes. DTPA, along with its calcium and zinc trisodium salts, are the only FDA approved agents for the treatment of internal contamination by transuranics.A32501 It is currently considered, in all the dosage forms, as a member of the list of approved inactive ingredients for drug products by the FDA.L2242 DPTA was developed by the pharmaceutical company CIS US and FDA approved on April 14, 2004.L1469

Struktur Molekul 2D

Berat 393.349
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) In preclinical studies, DTPA has been shown to present a very short half-life of 18.5-31.8 min after intravenous administration.
Volume Distribusi The volume of distribution of DPTA is 17 L.[T168]
Klirens (Clearance) Pentetic acid presents a very rapid blood clearance which explains for the short half-life.[A32508] The reported clearance rate in patients with normal renal function is 80-120ml/min.[T168]

Absorpsi

DTPA and its trisodium salts present a very poor bioavailability after oral administration. Therefore, the normal administration of DTPA is done by slow intravenous infusion or inhalation with a nebulizer.A32501 When inhaled, the absorption is of about 20% of the administered dose.A32511

Metabolisme

Pentetic acid and its derivatives present a very minimal metabolism in the body.A32511

Rute Eliminasi

DTPA metal complexes are quickly excreted in the urine.L2243It is predominantly excreted by the kidney and it is not excreted by non-renal routes to any significant extent.T168

Interaksi Obat

727 Data
Technetium Tc-99m oxidronate Pentetic acid may decrease effectiveness of Technetium Tc-99m oxidronate as a diagnostic agent.
Cyclosporine Cyclosporine may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Icosapent Icosapent may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cefotiam Cefotiam may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Mesalazine Mesalazine may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cefmenoxime Cefmenoxime may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cefmetazole Cefmetazole may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Pamidronic acid Pamidronic acid may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Tenofovir disoproxil Tenofovir disoproxil may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Indomethacin Indomethacin may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cidofovir Cidofovir may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cefpiramide Cefpiramide may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Ceftazidime Ceftazidime may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Loracarbef Loracarbef may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cefalotin Cefalotin may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Nabumetone Nabumetone may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Ketorolac Ketorolac may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Tenoxicam Tenoxicam may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cefotaxime Cefotaxime may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Tolmetin Tolmetin may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Foscarnet Foscarnet may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Rofecoxib Rofecoxib may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Piroxicam Piroxicam may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Methotrexate Methotrexate may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cephalexin Cephalexin may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Fenoprofen Fenoprofen may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Valaciclovir Valaciclovir may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Valdecoxib Valdecoxib may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Diclofenac Diclofenac may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Sulindac Sulindac may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Bacitracin Bacitracin may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Amphotericin B Amphotericin B may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cephaloglycin Cephaloglycin may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Flurbiprofen Flurbiprofen may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Pentamidine Pentamidine may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Etodolac Etodolac may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Mefenamic acid Mefenamic acid may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Acyclovir Acyclovir may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Naproxen Naproxen may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Sulfasalazine Sulfasalazine may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Phenylbutazone Phenylbutazone may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Meloxicam Meloxicam may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Carprofen Carprofen may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cefaclor Cefaclor may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Diflunisal Diflunisal may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Tacrolimus Tacrolimus may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Ceforanide Ceforanide may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Salicylic acid Salicylic acid may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Meclofenamic acid Meclofenamic acid may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Carboplatin Carboplatin may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Oxaprozin Oxaprozin may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Ketoprofen Ketoprofen may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Balsalazide Balsalazide may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Ibuprofen Ibuprofen may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cefditoren Cefditoren may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Atazanavir Atazanavir may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Colistimethate Colistimethate may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cefuroxime Cefuroxime may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cefapirin Cefapirin may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cefadroxil Cefadroxil may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cefprozil Cefprozil may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Ceftriaxone Ceftriaxone may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Olsalazine Olsalazine may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Lumiracoxib Lumiracoxib may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cefamandole Cefamandole may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cefazolin Cefazolin may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cefonicid Cefonicid may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cefoperazone Cefoperazone may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cefotetan Cefotetan may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cefoxitin Cefoxitin may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Ceftizoxime Ceftizoxime may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cefradine Cefradine may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Magnesium salicylate Magnesium salicylate may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Salsalate Salsalate may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Choline magnesium trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cefepime Cefepime may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cefacetrile Cefacetrile may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Ceftibuten Ceftibuten may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cefpodoxime Cefpodoxime may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Antrafenine Antrafenine may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Aminophenazone Aminophenazone may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Antipyrine Antipyrine may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Tiaprofenic acid Tiaprofenic acid may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Lopinavir Lopinavir may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Etoricoxib Etoricoxib may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Hydrolyzed Cephalothin Hydrolyzed Cephalothin may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cephalothin Group Cephalothin Group may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Oxyphenbutazone Oxyphenbutazone may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Latamoxef Latamoxef may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Nimesulide Nimesulide may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Benoxaprofen Benoxaprofen may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Metamizole Metamizole may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Zomepirac Zomepirac may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Ceftobiprole Ceftobiprole may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Cimicoxib Cimicoxib may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Ceftaroline fosamil Ceftaroline fosamil may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Lornoxicam Lornoxicam may decrease the excretion rate of Pentetic acid which could result in a higher serum level.

Target Protein

Transuranium elements

Referensi & Sumber

Artikel (PubMed)
Textbook
  • Reilly R. (2013). The fundamental principles of compartmental pharmacokinetics illustrated by radiopharmaceuticals commonly used in nuclear medicine. ACPE.
  • Zhou H. and Theil F. (2016). ADME amd translational pharmacokinetics/pharmacodynamics of therapeutic proteins. John Wiley & Sons.

Contoh Produk & Brand

Produk: 7 • International brands: 0
Produk
  • Draximage Dtpa
    Injection, powder, lyophilized, for solution • 20 mg/1 • Intravenous; Respiratory (inhalation) • US • Approved
  • Kit for the Preparation of Technetium Tc 99m Pentetate Injection
    Injection • 20.6 mg/10mL • Intravenous • US • Approved
  • Pentetate calcium trisodium
    Injection, solution, concentrate • 1000 mg/5mL • Intravenous; Respiratory (inhalation) • US • Approved
  • Pentetate Calcium Trisodium
    Injection, solution, concentrate • 200 mg/1mL • Intravenous; Respiratory (inhalation) • US • Approved
  • Pentetate Zinc Trisodium
    Injection, solution, concentrate • 200 mg/1mL • Intravenous; Respiratory (inhalation) • US • Approved
  • Pentetate zinc trisodium
    Injection, solution, concentrate • 1000 mg/5mL • Intravenous; Respiratory (inhalation) • US • Approved
  • Pentetic Acid
    Injection • 20 mg/1 • Intravenous • US • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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