Peringatan Keamanan

The reported LD50 in preclinical rat studies after oral administration of dimethicones is 4070 mg/Kg.MSDS Long-term use of dimethicone in skin products may cause skin irritation and impaired cell development. Under the FDA, dimethicone is considered as a safe substance for human use.L2162

Dimethicone 410

DB14005

small molecule approved

Deskripsi

Dimethicone is a silicone-based polymer used as a moisturizer in different skin OTC products.A32462 It is formed by repeated polymeric units of -(CH3)2SiO- with a terminal trimethyl siloxy unit.L1769 It is currently recognized by the FDA as a skin protectant OTC ingredient for human use in a concentration of 1-30%.L2162 The name dimethicone has a lot of nomenclature inconsistencies as it is used to refer to common names, generic names, trade names or even for the listing of mixtures. It is reported that the term dimethicone includes the notation of polydimethylsiloxane and trimethylsiloxy-terminated fluids between 20-30,000 cSt (viscosity).L2163

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) As dimethicone is pharmacologically inert and it is not absorbed, pharmacokinetic studies regarding its half-life are not relevant.
Volume Distribusi As dimethicone is pharmacologically inert and it is not absorbed, pharmacokinetic studies regarding the volume of distribution are not relevant.
Klirens (Clearance) A very minimal amount of dimethicone is excreted unchanged in urine.[L1769]

Absorpsi

The use of dimethicone in skin moisturizers or anti-lice products have proven a very low absorption rate. Studies have indicated that approximately 0.5% of the dose applied to the skin could be considered as bioavailable. When given orally, as it is administered in anti-gas medications, dimethicone 410 is not absorbed or absorbed in very minimal quantities that account only for 0.001-0.2% of the administered dose. Therefore, a minimal to absent dimethicone form can be detected outside of the GI tract.L1769

Metabolisme

Dimethicone 410 is not metabolized and it is excreted unchanged.L1769

Rute Eliminasi

In preclinical trials of skin preparations, dimethicone 410 was collected in trace levels in feces, expired air and subcutaneous swabs. When given orally, the entire dose of dimethicone can be found unchanged in feces and the recovery can account for even 99.6-99.8% of the administered dose. The limited absorbed dose can be found in urine as unchanged dimethicone.L1769

Interaksi Obat

0 Data
Tidak ada data.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 26092045
    Ihde ES, Boscamp JR, Loh JM, Rosen L: Safety and efficacy of a 100% dimethicone pediculocide in school-age children. BMC Pediatr. 2015 Jun 20;15:70. doi: 10.1186/s12887-015-0381-0.
  • PMID: 24847408
    Chularojanamontri L, Tuchinda P, Kulthanan K, Pongparit K: Moisturizers for Acne: What are their Constituents? J Clin Aesthet Dermatol. 2014 May;7(5):36-44.
Textbook
  • Washington N. (1961). Antacids and anti-reflux agents. CRC Press .
  • Schueller R. and Romanowski P. (1999). Conditioning Agents for Hair and Skin. Marcel Dekker.

Contoh Produk & Brand

Produk: 8 • International brands: 0
Produk
  • FIRST Mouthwash BLM
    Kit • - • Oral • US
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    Capsule, liquid filled • 180 mg/1 • Oral • US • OTC
  • Infants Relief Non-Staining Formula
    Liquid • 20 mg/0.3mL • Oral • US • OTC
  • Phazyme
    Capsule, gelatin coated • 180 mg/1 • Oral • US • OTC
  • Phazyme
    Capsule, gelatin coated • 180 mg/1 • Oral • US • OTC
  • Phazyme
    Capsule, gelatin coated • 180 mg/1 • Oral • US • OTC
  • Phazyme
    Capsule, gelatin coated • 180 mg/1 • Oral • US • OTC
  • Simethicone
    Capsule, liquid filled • 180 mg/1 • Oral • US • OTC

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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