Peringatan Keamanan

Overdosage with strontium chloride toothpaste formulations has not been reported.

Strontium chloride

DB13987

small molecule approved

Deskripsi

Strontium chloride (SrCl2) is a salt of strontium and chloride. SrCl2 is useful in reducing tooth sensitivity by forming a barrier over microscopic tubules in the dentin containing nerve endings that have become exposed by gum recession A33167, A33168. This kind of barrier protection for tooth hypersensitivity has, however, been superseded by other toothpaste formulations and ingredients designed to be nerve calming agents instead A33167, A33168. Such strontium chloride toothpaste formulations may subsequently not be available for sale anymore in certain parts of the world A33167, A33168.

Struktur Molekul 2D

Berat 158.52
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Readily accessible information about the half-life of strontium calcium used in toothpastes is not available.
Volume Distribusi The distribution of absorbed strontium in the human body is similar to that of calcium, with about 99% of total amount in the body being distributed in the skeleton [F118].
Klirens (Clearance) Despite being the major route of excretion of absorbed strontium, urinary excretion of absorbed strontium is observed to be slow [F118].

Absorpsi

About 30 percent of ingested strontium is absorbed into the blood through the gut L2886. The amount of strontium absorbed tends to decrease with age and is higher (about 60 percent) in children in their first year of life L2886. Once it is absorbed into the blood, most of it ends up in bone; with the remainder going to soft tissues or being excreted in urine, feces, and sweat L2886. About 8 percent of ingested strontium remains in the body after 30 days, and this decreases to about 4 percent after 1 year L2886.

Metabolisme

Strontium can bind to proteins and, based on its similarity to calcium, probably forms complexes with various inorganic anions, such as carbonate and phosphate, and carboxylic acids, such as citrate and lactate F118. Strontium can also interact with ligands that normally bind calcium, like hypoxyapatite, the main component of mineralized bone, and a variety of calcium-binding and calcium transport proteins that are important in the physiological disposition of calcium in cells, including Ca2+ adenosine triphosphatases, Na+Ca+ antiport], and Ca2+ channels F118.

Rute Eliminasi

Once strontium is absorbed into the blood, most of it ends up in bone; with the remainder going to soft tissues or being excreted in urine, feces, and sweat L2886.

Interaksi Obat

727 Data
Cyclosporine Cyclosporine may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Icosapent Icosapent may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cefotiam Cefotiam may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Mesalazine Mesalazine may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cefmenoxime Cefmenoxime may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cefmetazole Cefmetazole may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Pamidronic acid Pamidronic acid may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Tenofovir disoproxil Tenofovir disoproxil may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Indomethacin Indomethacin may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cidofovir Cidofovir may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cefpiramide Cefpiramide may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Ceftazidime Ceftazidime may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Loracarbef Loracarbef may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cefalotin Cefalotin may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Nabumetone Nabumetone may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Ketorolac Ketorolac may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Tenoxicam Tenoxicam may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cefotaxime Cefotaxime may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Tolmetin Tolmetin may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Foscarnet Foscarnet may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Rofecoxib Rofecoxib may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Piroxicam Piroxicam may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Methotrexate Methotrexate may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cephalexin Cephalexin may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Fenoprofen Fenoprofen may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Valaciclovir Valaciclovir may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Valdecoxib Valdecoxib may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Diclofenac Diclofenac may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Sulindac Sulindac may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Bacitracin Bacitracin may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Amphotericin B Amphotericin B may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cephaloglycin Cephaloglycin may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Flurbiprofen Flurbiprofen may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Pentamidine Pentamidine may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Etodolac Etodolac may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Mefenamic acid Mefenamic acid may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Acyclovir Acyclovir may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Naproxen Naproxen may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Sulfasalazine Sulfasalazine may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Phenylbutazone Phenylbutazone may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Meloxicam Meloxicam may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Carprofen Carprofen may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cefaclor Cefaclor may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Diflunisal Diflunisal may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Tacrolimus Tacrolimus may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Ceforanide Ceforanide may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Salicylic acid Salicylic acid may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Meclofenamic acid Meclofenamic acid may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Carboplatin Carboplatin may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Oxaprozin Oxaprozin may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Ketoprofen Ketoprofen may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Balsalazide Balsalazide may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Ibuprofen Ibuprofen may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cefditoren Cefditoren may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Atazanavir Atazanavir may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Colistimethate Colistimethate may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cefuroxime Cefuroxime may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cefapirin Cefapirin may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cefadroxil Cefadroxil may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cefprozil Cefprozil may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Ceftriaxone Ceftriaxone may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Olsalazine Olsalazine may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Lumiracoxib Lumiracoxib may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cefamandole Cefamandole may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cefazolin Cefazolin may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cefonicid Cefonicid may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cefoperazone Cefoperazone may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cefotetan Cefotetan may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cefoxitin Cefoxitin may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Ceftizoxime Ceftizoxime may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cefradine Cefradine may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Lithium cation Lithium cation may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Magnesium salicylate Magnesium salicylate may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Salsalate Salsalate may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Choline magnesium trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cefepime Cefepime may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cefacetrile Cefacetrile may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Ceftibuten Ceftibuten may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cefpodoxime Cefpodoxime may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Antrafenine Antrafenine may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Aminophenazone Aminophenazone may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Antipyrine Antipyrine may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Phenazopyridine Phenazopyridine may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Tiaprofenic acid Tiaprofenic acid may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Lopinavir Lopinavir may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Etoricoxib Etoricoxib may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Hydrolyzed Cephalothin Hydrolyzed Cephalothin may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cephalothin Group Cephalothin Group may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Oxyphenbutazone Oxyphenbutazone may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Latamoxef Latamoxef may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Nimesulide Nimesulide may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Benoxaprofen Benoxaprofen may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Metamizole Metamizole may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Zomepirac Zomepirac may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Ceftobiprole Ceftobiprole may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Cimicoxib Cimicoxib may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Ceftaroline fosamil Ceftaroline fosamil may decrease the excretion rate of Strontium chloride which could result in a higher serum level.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 23653647
    Karim BF, Gillam DG: The efficacy of strontium and potassium toothpastes in treating dentine hypersensitivity: a systematic review. Int J Dent. 2013;2013:573258. doi: 10.1155/2013/573258. Epub 2013 Apr 8.
  • PMID: 17037886
    Bartold PM: Dentinal hypersensitivity: a review. Aust Dent J. 2006 Sep;51(3):212-8; quiz 276.

Contoh Produk & Brand

Produk: 1 • International brands: 0
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    Gel • - • Dental • Canada • OTC • Approved

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