Peringatan Keamanan

Readily available information regarding the pharmacokinetics of isopropyl myristate is not available L1978, T151.

Isopropyl myristate

DB13966

small molecule approved experimental

Deskripsi

Isopropyl myristate is a moisturizer with polar characteristics used in cosmetics and topical medical preparations to ameliorate the skin absorption. Isopropyl myristate has been largely studied and impulsed as a skin penetration enhancer.A178078

At the moment the primary usage for which isopropyl myristate is formally indicated is as the active ingredient in a non-prescription pediculicide rinse A32333, L1964, L1966.

Struktur Molekul 2D

Berat 270.4507
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Readily available information regarding the pharmacokinetics of isopropyl myristate is not available [L1978, T151].
Volume Distribusi Readily available information regarding the pharmacokinetics of isopropyl myristate is not available [L1978, T151].
Klirens (Clearance) Readily available information regarding the pharmacokinetics of isopropyl myristate is not available [L1978, T151].

Absorpsi

Dermal absorption of isopropyl myristate is predicated to be 0.00020 mg/cm2/event, which is considered a very low absorption rate L1969. In a study, topically applied isopropyl myristate was largely retained in the stratum corneum A32332. It was not detected in the receptor fluid of flow-through diffusion cells in in-vitro skin permeation experiments using human epidermis (stratum corneum and viable epidermis) and dermis of varying thickness A32332.

Metabolisme

Any isopropyl myristate that is absorbed is likely to be hydrolyzed to its component compounds of isopropylalcohol and myristic acid L1973.

Rute Eliminasi

Readily available information regarding the pharmacokinetics of isopropyl myristate is not available L1978, T151.

Interaksi Obat

0 Data
Tidak ada data.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 19423676
    Authors unspecified: Update on treatments for head lice. Drug Ther Bull. 2009 May;47(5):50-2. doi: 10.1136/dtb.2009.04.0014.
  • PMID: 18563737
    Liu P, Cettina M, Wong J: Effects of isopropanol-isopropyl myristate binary enhancers on in vitro transport of estradiol in human epidermis: a mechanistic evaluation. J Pharm Sci. 2009 Feb;98(2):565-72. doi: 10.1002/jps.21459.
  • PMID: 17942025
    Kaul N, Palma KG, Silagy SS, Goodman JJ, Toole J: North American efficacy and safety of a novel pediculicide rinse, isopropyl myristate 50% (Resultz). J Cutan Med Surg. 2007 Sep-Oct;11(5):161-7. doi: 10.2310/7750.2007.00045.
  • PMID: 22943314
    Barnett E, Palma KG, Clayton B, Ballard T: Effectiveness of isopropyl myristate/cyclomethicone D5 solution of removing cuticular hydrocarbons from human head lice (Pediculus humanus capitis). BMC Dermatol. 2012 Sep 3;12:15. doi: 10.1186/1471-5945-12-15.
  • PMID: 28132900
    Eichner A, Stahlberg S, Sonnenberger S, Lange S, Dobner B, Ostermann A, Schrader TE, Hauss T, Schroeter A, Huster D, Neubert RH: Influence of the penetration enhancer isopropyl myristate on stratum corneum lipid model membranes revealed by neutron diffraction and (2)H NMR experiments. Biochim Biophys Acta Biomembr. 2017 May;1859(5):745-755. doi: 10.1016/j.bbamem.2017.01.029. Epub 2017 Jan 26.
Textbook
  • ISBN: 9780323292658
    Kathy Moscou, Karen Snipe (2014). Pharmacology for Pharmacy Technicians. Elsevier Health Sciences.

Contoh Produk & Brand

Produk: 2 • International brands: 1
Produk
  • Resultz
    Solution • 50 % w/w • Topical • Canada • OTC • Approved
  • Secol
    Liquid • - • Topical • Canada • OTC • Approved
International Brands
  • Estergel

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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