Estradiol Dienanthate is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol benzoate therefore has the same downstream effects within the body through binding to the Estrogen Receptor (ER) including ER? and ER? subtypes, which are located in various tissues including in the breasts, uterus, ovaries, skin, prostate, bone, fat, and brain.
Estradiol is commonly produced with an ester side-chain as endogenous estradiol has very low oral bioavailability on its own (2-10%). First-pass metabolism by the gut and the liver quickly degrades the estradiol molecule before it gets a chance to enter systemic circulation and exert its estrogenic effects A12102. Esterification of estradiol aims to improves absorption and bioavailability after oral administration (such as with Estradiol valerate) or to sustain release from depot intramuscular injections (such as with Estradiol Cypionate) through improved lipophilicity. Following absorption, the esters are cleaved, resulting in the release of endogenous estradiol, or 17?-estradiol. Ester pro-drugs of estradiol are therefore considered to be bioidentical forms of estrogen T84.
Estradiol dienanthate is not currently available in any commercially available products in Canada or the US.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Tizanidine | The serum concentration of Tizanidine can be increased when it is combined with Estradiol dienanthate. |
| Aripiprazole | The metabolism of Aripiprazole can be increased when combined with Estradiol dienanthate. |
| Aripiprazole lauroxil | The metabolism of Aripiprazole lauroxil can be increased when combined with Estradiol dienanthate. |
| Deferasirox | The serum concentration of Estradiol dienanthate can be increased when it is combined with Deferasirox. |
| Peginterferon alfa-2b | The serum concentration of Estradiol dienanthate can be increased when it is combined with Peginterferon alfa-2b. |
| Leflunomide | The serum concentration of Estradiol dienanthate can be decreased when it is combined with Leflunomide. |
| Teriflunomide | The serum concentration of Estradiol dienanthate can be decreased when it is combined with Teriflunomide. |
| Zolmitriptan | The metabolism of Zolmitriptan can be decreased when combined with Estradiol dienanthate. |
| Mifepristone | The serum concentration of Estradiol dienanthate can be increased when it is combined with Mifepristone. |
| Ifosfamide | The metabolism of Ifosfamide can be increased when combined with Estradiol dienanthate. |
| Perampanel | The metabolism of Perampanel can be increased when combined with Estradiol dienanthate. |
| Warfarin | The metabolism of Warfarin can be increased when combined with Estradiol dienanthate. |
| Acenocoumarol | The metabolism of Acenocoumarol can be increased when combined with Estradiol dienanthate. |
| (R)-warfarin | The metabolism of (R)-warfarin can be increased when combined with Estradiol dienanthate. |
| R,S-Warfarin alcohol | The metabolism of R,S-Warfarin alcohol can be increased when combined with Estradiol dienanthate. |
| S,R-Warfarin alcohol | The metabolism of S,R-Warfarin alcohol can be increased when combined with Estradiol dienanthate. |
| (S)-Warfarin | The metabolism of (S)-Warfarin can be increased when combined with Estradiol dienanthate. |
| Zidovudine | The metabolism of Estradiol dienanthate can be increased when combined with Zidovudine. |
| Lamotrigine | The metabolism of Estradiol dienanthate can be increased when combined with Lamotrigine. |
| Ethinylestradiol | The metabolism of Estradiol dienanthate can be increased when combined with Ethinylestradiol. |
| Testosterone propionate | The metabolism of Estradiol dienanthate can be increased when combined with Testosterone propionate. |
| Abiraterone | The serum concentration of Estradiol dienanthate can be increased when it is combined with Abiraterone. |
| Eluxadoline | The serum concentration of Eluxadoline can be increased when it is combined with Estradiol dienanthate. |
| Cyproterone acetate | The metabolism of Estradiol dienanthate can be increased when combined with Cyproterone acetate. |
| Erlotinib | The serum concentration of Erlotinib can be decreased when it is combined with Estradiol dienanthate. |
| Primidone | The metabolism of Estradiol dienanthate can be increased when combined with Primidone. |
| Albendazole | The metabolism of Estradiol dienanthate can be increased when combined with Albendazole. |
| Caffeine | The metabolism of Estradiol dienanthate can be decreased when combined with Caffeine. |
| Moxifloxacin | The metabolism of Estradiol dienanthate can be decreased when combined with Moxifloxacin. |
| Mexiletine | The metabolism of Estradiol dienanthate can be decreased when combined with Mexiletine. |
| Alosetron | The metabolism of Estradiol dienanthate can be decreased when combined with Alosetron. |
| Gatifloxacin | The metabolism of Estradiol dienanthate can be decreased when combined with Gatifloxacin. |
| Simeprevir | The metabolism of Estradiol dienanthate can be decreased when combined with Simeprevir. |
| Lobeglitazone | The metabolism of Estradiol dienanthate can be decreased when combined with Lobeglitazone. |
| Pazufloxacin | The metabolism of Estradiol dienanthate can be decreased when combined with Pazufloxacin. |
| Lidocaine | The metabolism of Estradiol dienanthate can be decreased when combined with Lidocaine. |
| Osilodrostat | The metabolism of Estradiol dienanthate can be decreased when combined with Osilodrostat. |
| Fluoxetine | The metabolism of Estradiol dienanthate can be decreased when combined with Fluoxetine. |
| Nabilone | The metabolism of Estradiol dienanthate can be decreased when combined with Nabilone. |
| Felbamate | The metabolism of Estradiol dienanthate can be decreased when combined with Felbamate. |
| Sulfinpyrazone | The metabolism of Estradiol dienanthate can be decreased when combined with Sulfinpyrazone. |
| Iproniazid | The metabolism of Estradiol dienanthate can be decreased when combined with Iproniazid. |
| Medical Cannabis | The metabolism of Estradiol dienanthate can be decreased when combined with Medical Cannabis. |
| Troglitazone | The metabolism of Estradiol dienanthate can be decreased when combined with Troglitazone. |
| Imatinib | The metabolism of Estradiol dienanthate can be decreased when combined with Imatinib. |
| Valproic acid | The metabolism of Estradiol dienanthate can be decreased when combined with Valproic acid. |
| Fluconazole | The metabolism of Estradiol dienanthate can be decreased when combined with Fluconazole. |
| Floxuridine | The metabolism of Estradiol dienanthate can be decreased when combined with Floxuridine. |
| Nicardipine | The metabolism of Estradiol dienanthate can be decreased when combined with Nicardipine. |
| Miconazole | The metabolism of Estradiol dienanthate can be decreased when combined with Miconazole. |
| Gemfibrozil | The metabolism of Estradiol dienanthate can be decreased when combined with Gemfibrozil. |
| Sulfaphenazole | The metabolism of Estradiol dienanthate can be decreased when combined with Sulfaphenazole. |
| Secobarbital | The metabolism of Estradiol dienanthate can be increased when combined with Secobarbital. |
| Bexarotene | The metabolism of Estradiol dienanthate can be decreased when combined with Bexarotene. |
| Spironolactone | Spironolactone may increase the excretion rate of Estradiol dienanthate which could result in a lower serum level and potentially a reduction in efficacy. |
| Medroxyprogesterone acetate | The metabolism of Estradiol dienanthate can be decreased when combined with Medroxyprogesterone acetate. |
| Irbesartan | The metabolism of Estradiol dienanthate can be decreased when combined with Irbesartan. |
| Oxybutynin | The metabolism of Estradiol dienanthate can be decreased when combined with Oxybutynin. |
| Fluvastatin | The metabolism of Estradiol dienanthate can be decreased when combined with Fluvastatin. |
| Pioglitazone | The metabolism of Estradiol dienanthate can be decreased when combined with Pioglitazone. |
| Topiroxostat | The metabolism of Estradiol dienanthate can be decreased when combined with Topiroxostat. |
| Trimethoprim | The metabolism of Estradiol dienanthate can be decreased when combined with Trimethoprim. |
| Quinine | The metabolism of Estradiol dienanthate can be decreased when combined with Quinine. |
| Loratadine | The metabolism of Estradiol dienanthate can be decreased when combined with Loratadine. |
| Levothyroxine | The metabolism of Estradiol dienanthate can be decreased when combined with Levothyroxine. |
| Fluticasone propionate | The metabolism of Estradiol dienanthate can be decreased when combined with Fluticasone propionate. |
| Clopidogrel | The metabolism of Estradiol dienanthate can be decreased when combined with Clopidogrel. |
| Candesartan cilexetil | The metabolism of Estradiol dienanthate can be decreased when combined with Candesartan cilexetil. |
| Salmeterol | The metabolism of Estradiol dienanthate can be decreased when combined with Salmeterol. |
| Fluticasone furoate | The metabolism of Estradiol dienanthate can be decreased when combined with Fluticasone furoate. |
| Trametinib | Trametinib may decrease the excretion rate of Estradiol dienanthate which could result in a higher serum level. |
| Fluticasone | The metabolism of Estradiol dienanthate can be decreased when combined with Fluticasone. |
| Mometasone furoate | The metabolism of Estradiol dienanthate can be decreased when combined with Mometasone furoate. |
| Felodipine | The metabolism of Estradiol dienanthate can be decreased when combined with Felodipine. |
| Osimertinib | The serum concentration of Estradiol dienanthate can be decreased when it is combined with Osimertinib. |
| Tipiracil | The excretion of Tipiracil can be decreased when combined with Estradiol dienanthate. |
| Vemurafenib | The serum concentration of Estradiol dienanthate can be increased when it is combined with Vemurafenib. |
| Pitolisant | The serum concentration of Estradiol dienanthate can be decreased when it is combined with Pitolisant. |
| Folic acid | Estradiol dienanthate may decrease the excretion rate of Folic acid which could result in a higher serum level. |
| Pravastatin | Estradiol dienanthate may decrease the excretion rate of Pravastatin which could result in a higher serum level. |
| Conjugated estrogens | Estradiol dienanthate may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level. |
| Cerivastatin | Estradiol dienanthate may decrease the excretion rate of Cerivastatin which could result in a higher serum level. |
| Celecoxib | Estradiol dienanthate may decrease the excretion rate of Celecoxib which could result in a higher serum level. |
| Sumatriptan | Estradiol dienanthate may decrease the excretion rate of Sumatriptan which could result in a higher serum level. |
| Mycophenolate mofetil | Estradiol dienanthate may decrease the excretion rate of Mycophenolate mofetil which could result in a higher serum level. |
| Nitrofurantoin | Estradiol dienanthate may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level. |
| Riluzole | Estradiol dienanthate may decrease the excretion rate of Riluzole which could result in a higher serum level. |
| Sulfasalazine | Estradiol dienanthate may decrease the excretion rate of Sulfasalazine which could result in a higher serum level. |
| Ezetimibe | Estradiol dienanthate may decrease the excretion rate of Ezetimibe which could result in a higher serum level. |
| Topotecan | Estradiol dienanthate may decrease the excretion rate of Topotecan which could result in a higher serum level. |
| Rosuvastatin | Estradiol dienanthate may decrease the excretion rate of Rosuvastatin which could result in a higher serum level. |
| Alvocidib | Estradiol dienanthate may decrease the excretion rate of Alvocidib which could result in a higher serum level. |
| Camptothecin | Estradiol dienanthate may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Apixaban | Estradiol dienanthate may decrease the excretion rate of Apixaban which could result in a higher serum level. |
| Dolutegravir | Estradiol dienanthate may decrease the excretion rate of Dolutegravir which could result in a higher serum level. |
| Riociguat | Estradiol dienanthate may decrease the excretion rate of Riociguat which could result in a higher serum level. |
| Sofosbuvir | Estradiol dienanthate may decrease the excretion rate of Sofosbuvir which could result in a higher serum level. |
| Lenvatinib | Estradiol dienanthate may decrease the excretion rate of Lenvatinib which could result in a higher serum level. |
| Fimasartan | Estradiol dienanthate may decrease the excretion rate of Fimasartan which could result in a higher serum level. |
| Talazoparib | The serum concentration of Talazoparib can be increased when it is combined with Estradiol dienanthate. |