Oral TDLO reported in man is 3.14 mg/kg/42D (intermittent) MSDS. While limited cases of soft stool, belching, and abdominal bloating have been reported from dietary supplements containing gamolenic acid, daily doses up to 2.8 g were well tolerated F27.
Gamolenic acid, or gamma-linolenic acid (?-Linolenic acid) or GLA, is an essential fatty acid (EFA) comprised of 18 carbon atoms with three double bonds F27 that is most commonly found in human milk and other botanical sources A32848. It is an omega-6 polyunsaturated fatty acid (PUFA) also referred to as 18:3n-6; 6,9,12-octadecatrienoic acid; and cis-6, cis-9, cis-12- octadecatrienoic acid F27. Gamolenic acid is produced minimally in the body as the delta 6-desaturase metabolite of DB00132. It is converted to DB00154, a biosynthetic precursor of monoenoic prostaglandins such as PGE1. While Gamolenic acid is found naturally in the fatty acid fractions of some plant seed oils F27, DB11358 and DB11238 are rich sources of gamolenic acid. Evening primrose oil has been investigated for clinical use in menopausal syndrome, diabetic neuropathy, and breast pain, where gamolenic acid is present at concentrations of 7-14% F27. Gamolenic acid may be found in over-the-counter dietary supplements. Gamolenic acid is also found in some fungal sources and also present naturally in the form of triglycerides F27. Various clinical indications of gamolenic acid have been studied, including rheumatoid arthritis, atopic eczema, acute respiratory distress syndrome, asthma, premenstrual syndrome, cardiovascular disease, ulcerative colitis, ADHD, cancer, osteoporosis, diabetic neuropathy, and insomnia.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Lorazepam | The therapeutic efficacy of Lorazepam can be decreased when used in combination with Gamolenic acid. |
| Pregabalin | The therapeutic efficacy of Pregabalin can be decreased when used in combination with Gamolenic acid. |
| Butalbital | The therapeutic efficacy of Butalbital can be decreased when used in combination with Gamolenic acid. |
| Phenytoin | The therapeutic efficacy of Phenytoin can be decreased when used in combination with Gamolenic acid. |
| Topiramate | The therapeutic efficacy of Topiramate can be decreased when used in combination with Gamolenic acid. |
| Pentobarbital | The therapeutic efficacy of Pentobarbital can be decreased when used in combination with Gamolenic acid. |
| Valproic acid | The therapeutic efficacy of Valproic acid can be decreased when used in combination with Gamolenic acid. |
| Trimethadione | The therapeutic efficacy of Trimethadione can be decreased when used in combination with Gamolenic acid. |
| Clobazam | The therapeutic efficacy of Clobazam can be decreased when used in combination with Gamolenic acid. |
| Secobarbital | The therapeutic efficacy of Secobarbital can be decreased when used in combination with Gamolenic acid. |
| Metharbital | The therapeutic efficacy of Metharbital can be decreased when used in combination with Gamolenic acid. |
| Methohexital | The therapeutic efficacy of Methohexital can be decreased when used in combination with Gamolenic acid. |
| Mephenytoin | The therapeutic efficacy of Mephenytoin can be decreased when used in combination with Gamolenic acid. |
| Lamotrigine | The therapeutic efficacy of Lamotrigine can be decreased when used in combination with Gamolenic acid. |
| Carbamazepine | The therapeutic efficacy of Carbamazepine can be decreased when used in combination with Gamolenic acid. |
| Ethosuximide | The therapeutic efficacy of Ethosuximide can be decreased when used in combination with Gamolenic acid. |
| Thiopental | The therapeutic efficacy of Thiopental can be decreased when used in combination with Gamolenic acid. |
| Paramethadione | The therapeutic efficacy of Paramethadione can be decreased when used in combination with Gamolenic acid. |
| Clorazepic acid | The therapeutic efficacy of Clorazepic acid can be decreased when used in combination with Gamolenic acid. |
| Magnesium sulfate | The therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Gamolenic acid. |
| Tizanidine | The therapeutic efficacy of Tizanidine can be decreased when used in combination with Gamolenic acid. |
| Riluzole | The therapeutic efficacy of Riluzole can be decreased when used in combination with Gamolenic acid. |
| Ethotoin | The therapeutic efficacy of Ethotoin can be decreased when used in combination with Gamolenic acid. |
| Oxcarbazepine | The therapeutic efficacy of Oxcarbazepine can be decreased when used in combination with Gamolenic acid. |
| Primidone | The therapeutic efficacy of Primidone can be decreased when used in combination with Gamolenic acid. |
| Acetazolamide | The therapeutic efficacy of Acetazolamide can be decreased when used in combination with Gamolenic acid. |
| Diazepam | The therapeutic efficacy of Diazepam can be decreased when used in combination with Gamolenic acid. |
| Phensuximide | The therapeutic efficacy of Phensuximide can be decreased when used in combination with Gamolenic acid. |
| Progabide | The therapeutic efficacy of Progabide can be decreased when used in combination with Gamolenic acid. |
| Methylphenobarbital | The therapeutic efficacy of Methylphenobarbital can be decreased when used in combination with Gamolenic acid. |
| Tiagabine | The therapeutic efficacy of Tiagabine can be decreased when used in combination with Gamolenic acid. |
| Zonisamide | The therapeutic efficacy of Zonisamide can be decreased when used in combination with Gamolenic acid. |
| Felbamate | The therapeutic efficacy of Felbamate can be decreased when used in combination with Gamolenic acid. |
| Zaleplon | The therapeutic efficacy of Zaleplon can be decreased when used in combination with Gamolenic acid. |
| Gabapentin | The therapeutic efficacy of Gabapentin can be decreased when used in combination with Gamolenic acid. |
| Clonazepam | The therapeutic efficacy of Clonazepam can be decreased when used in combination with Gamolenic acid. |
| Vigabatrin | The therapeutic efficacy of Vigabatrin can be decreased when used in combination with Gamolenic acid. |
| Phenacemide | The therapeutic efficacy of Phenacemide can be decreased when used in combination with Gamolenic acid. |
| Thiamylal | The therapeutic efficacy of Thiamylal can be decreased when used in combination with Gamolenic acid. |
| Phenobarbital | The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Gamolenic acid. |
| Levetiracetam | The therapeutic efficacy of Levetiracetam can be decreased when used in combination with Gamolenic acid. |
| Estazolam | The therapeutic efficacy of Estazolam can be decreased when used in combination with Gamolenic acid. |
| Fosphenytoin | The therapeutic efficacy of Fosphenytoin can be decreased when used in combination with Gamolenic acid. |
| Amobarbital | The therapeutic efficacy of Amobarbital can be decreased when used in combination with Gamolenic acid. |
| Hexobarbital | The therapeutic efficacy of Hexobarbital can be decreased when used in combination with Gamolenic acid. |
| Barbital | The therapeutic efficacy of Barbital can be decreased when used in combination with Gamolenic acid. |
| Delorazepam | The therapeutic efficacy of Delorazepam can be decreased when used in combination with Gamolenic acid. |
| Nitrazepam | The therapeutic efficacy of Nitrazepam can be decreased when used in combination with Gamolenic acid. |
| 7-Nitroindazole | The therapeutic efficacy of 7-Nitroindazole can be decreased when used in combination with Gamolenic acid. |
| Valpromide | The therapeutic efficacy of Valpromide can be decreased when used in combination with Gamolenic acid. |
| Flunarizine | The therapeutic efficacy of Flunarizine can be decreased when used in combination with Gamolenic acid. |
| Ezogabine | The therapeutic efficacy of Ezogabine can be decreased when used in combination with Gamolenic acid. |
| Methsuximide | The therapeutic efficacy of Methsuximide can be decreased when used in combination with Gamolenic acid. |
| Brivaracetam | The therapeutic efficacy of Brivaracetam can be decreased when used in combination with Gamolenic acid. |
| Rufinamide | The therapeutic efficacy of Rufinamide can be decreased when used in combination with Gamolenic acid. |
| Lacosamide | The therapeutic efficacy of Lacosamide can be decreased when used in combination with Gamolenic acid. |
| Remacemide | The therapeutic efficacy of Remacemide can be decreased when used in combination with Gamolenic acid. |
| Clomethiazole | The therapeutic efficacy of Clomethiazole can be decreased when used in combination with Gamolenic acid. |
| Deramciclane | The therapeutic efficacy of Deramciclane can be decreased when used in combination with Gamolenic acid. |
| Tramiprosate | The therapeutic efficacy of Tramiprosate can be decreased when used in combination with Gamolenic acid. |
| Gaboxadol | The therapeutic efficacy of Gaboxadol can be decreased when used in combination with Gamolenic acid. |
| Sulthiame | The therapeutic efficacy of Sulthiame can be decreased when used in combination with Gamolenic acid. |
| Perampanel | The therapeutic efficacy of Perampanel can be decreased when used in combination with Gamolenic acid. |
| Ifenprodil | The therapeutic efficacy of Ifenprodil can be decreased when used in combination with Gamolenic acid. |
| Barbexaclone | The therapeutic efficacy of Barbexaclone can be decreased when used in combination with Gamolenic acid. |
| Beclamide | The therapeutic efficacy of Beclamide can be decreased when used in combination with Gamolenic acid. |
| Cannabidiol | The therapeutic efficacy of Cannabidiol can be decreased when used in combination with Gamolenic acid. |
| Paraldehyde | The therapeutic efficacy of Paraldehyde can be decreased when used in combination with Gamolenic acid. |
| Stiripentol | The therapeutic efficacy of Stiripentol can be decreased when used in combination with Gamolenic acid. |
| Eslicarbazepine acetate | The therapeutic efficacy of Eslicarbazepine acetate can be decreased when used in combination with Gamolenic acid. |
| Doramectin | The therapeutic efficacy of Doramectin can be decreased when used in combination with Gamolenic acid. |
| Tiletamine | The therapeutic efficacy of Tiletamine can be decreased when used in combination with Gamolenic acid. |
| Brexanolone | The therapeutic efficacy of Brexanolone can be decreased when used in combination with Gamolenic acid. |
| Etiracetam | The therapeutic efficacy of Etiracetam can be decreased when used in combination with Gamolenic acid. |
| Vinpocetine | The therapeutic efficacy of Vinpocetine can be decreased when used in combination with Gamolenic acid. |
| Carisbamate | The therapeutic efficacy of Carisbamate can be decreased when used in combination with Gamolenic acid. |
| Pheneturide | The therapeutic efficacy of Pheneturide can be decreased when used in combination with Gamolenic acid. |
| Neocitrullamon | The therapeutic efficacy of Neocitrullamon can be decreased when used in combination with Gamolenic acid. |
| Medazepam | The therapeutic efficacy of Medazepam can be decreased when used in combination with Gamolenic acid. |
| Phenibut | The therapeutic efficacy of Phenibut can be decreased when used in combination with Gamolenic acid. |
| Ethadione | The therapeutic efficacy of Ethadione can be decreased when used in combination with Gamolenic acid. |
| Cannabidivarin | The therapeutic efficacy of Cannabidivarin can be decreased when used in combination with Gamolenic acid. |
| Eslicarbazepine | The therapeutic efficacy of Eslicarbazepine can be decreased when used in combination with Gamolenic acid. |
| JNJ-26489112 | The therapeutic efficacy of JNJ-26489112 can be decreased when used in combination with Gamolenic acid. |
| Cenobamate | The therapeutic efficacy of Cenobamate can be decreased when used in combination with Gamolenic acid. |
| Amifampridine | The risk or severity of seizure can be increased when Gamolenic acid is combined with Amifampridine. |
| Dalfampridine | The risk or severity of seizure can be increased when Gamolenic acid is combined with Dalfampridine. |
| Bupropion | The risk or severity of seizure can be increased when Bupropion is combined with Gamolenic acid. |
| Fenfluramine | The therapeutic efficacy of Fenfluramine can be decreased when used in combination with Gamolenic acid. |
| Ganaxolone | The therapeutic efficacy of Ganaxolone can be decreased when used in combination with Gamolenic acid. |
| Hydroxychloroquine | The risk or severity of seizure can be increased when Hydroxychloroquine is combined with Gamolenic acid. |