Peringatan Keamanan

Tilactase is known to present a low acute oral toxicity in preclinical trials. The lowest toxic dose for subcutaneous exposure is of 26 g/kg administered over 30 days.^L2340 There have not been performed enough studies regarding the use of pregnancy or related to the fetal development. There are no reports of overdose with tilactase.^L2345

Tilactase

DB13761

biotech approved experimental

Deskripsi

Tilactase is a beta-D-galactosidase obtained from Aspergillus oryzae. It is produced as a chewable tablet that has to be taken before the consumption of a lactose-containing meal.^A27172 The beta-D-galactosidase us a large monomeric multi-domain enzyme of 985 residues that presents a catalytic (alpha/beta)8-barrel domain.^A32591 It is considered by the WHO as part of the International Nonpropietary Names for Pharmaceutical Substances.^L2338

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) Tilactase half-life at 35ºC is registered to be 123.77 min. This half-life can be affected by temperature in an inversely proportional manner.[A32597]

Volume Distribusi Tilactase is not absorbed and thus the volume of distribution is not relevant.

Klirens (Clearance) Tilactase is not absorbed and thus the clearance rate is not relevant.

Absorpsi

Tilactase is not absorbed in the GI tract and thus the pharmacokinetic parameters related to absorption are not relevant.^L2345

Metabolisme

Tilactase is degraded by the stomach acid and by the normal flora bacterial metabolism.^L2345

Rute Eliminasi

Tilactase is completely eliminated in the feces either unchanged or as metabolites.^L2345

Interaksi Makanan

1 Data

1. Take before a meal. Take tilactase before eating food containing lactose.

Interaksi Obat

0 Data

Tidak ada data.

Target Protein

Lactose

Referensi & Sumber

Artikel (PubMed)

PMID: 19021701
Portincasa P, Di Ciaula A, Vacca M, Montelli R, Wang DQ, Palasciano G: Beneficial effects of oral tilactase on patients with hypolactasia. Eur J Clin Invest. 2008 Nov;38(11):835-44. doi: 10.1111/j.1365-2362.2008.02035.x.
PMID: 2502573
DiPalma JA, Collins MS: Enzyme replacement for lactose malabsorption using a beta-D-galactosidase. J Clin Gastroenterol. 1989 Jun;11(3):290-3.
PMID: 23688418
Maksimainen MM, Lampio A, Mertanen M, Turunen O, Rouvinen J: The crystal structure of acidic beta-galactosidase from Aspergillus oryzae. Int J Biol Macromol. 2013 Sep;60:109-15. doi: 10.1016/j.ijbiomac.2013.05.003. Epub 2013 May 17.
PMID: 26715083
Vandenplas Y: Lactose intolerance. Asia Pac J Clin Nutr. 2015;24 Suppl 1:S9-13.
PMID: 26396367
Selvarajan E, Mohanasrinivasan V: Kinetic studies on exploring lactose hydrolysis potential of beta galactosidase extracted from Lactobacillus plantarum HF571129. J Food Sci Technol. 2015 Oct;52(10):6206-17. doi: 10.1007/s13197-015-1729-z. Epub 2015 Jan 16.

Link

Contoh Produk & Brand

Produk: 12 • International brands: 3

Produk

Dairy Digestive Aid Tab 3000fcc Lactase Unit

Tablet • 3000 unit • Oral • Canada • OTC • Approved
Extra Strength Lactaid Tablets - 4500fcclu

Tablet • 4500 unit / tab • Oral • Canada • OTC • Approved
Lactace Cap 3400unit

Capsule • 3400 unit / cap • Oral • Canada • OTC • Approved
Lactaid Tab 3000unit

Tablet • 3000 unit • Oral • Canada • OTC • Approved
Lactaid Tab 3300unit

Tablet • 3300 unit • Oral • Canada • OTC • Approved
Lactase 3400 Fcc Units Cap

Capsule • 3400 unit / cap • Oral • Canada • OTC • Approved
Lactase Enzyme

Capsule • 3000 unit • Oral • Canada • OTC • Approved
Lactase Enzyme

Capsule • 3300 unit / cap • Oral • Canada • OTC • Approved

Menampilkan 8 dari 12 produk.

International Brands

Dairyaid — Major Pharmaceuticals
Lacdigest
Oryzatym

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.