Mesterolone

DB13587

small molecule experimental

Deskripsi

Mesterolone is a synthetic anabolic-androgenic steroid (AAS) and derivative of dihydrotestosterone (DHT). It is inactivated by 3?-hydroxysteroid dehydrogenase in skeleta muscules so it is considered a weak androgen. It is not a substrate for aromatase so it is not converted into estrogen. Mesterolone demonstrated to have minimal effect on sperm counts and levels of FSH or LH A27177, A27178. Experiments of mesterolone serving as a potential treatment of depression are still undergoing.

Struktur Molekul 2D

Berat 304.4669
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

173 Data
Cyclosporine The risk or severity of liver damage can be increased when Mesterolone is combined with Cyclosporine.
Dicoumarol Mesterolone may increase the anticoagulant activities of Dicoumarol.
Phenindione Mesterolone may increase the anticoagulant activities of Phenindione.
Warfarin Mesterolone may increase the anticoagulant activities of Warfarin.
Phenprocoumon Mesterolone may increase the anticoagulant activities of Phenprocoumon.
Acenocoumarol Mesterolone may increase the anticoagulant activities of Acenocoumarol.
4-hydroxycoumarin Mesterolone may increase the anticoagulant activities of 4-hydroxycoumarin.
Coumarin Mesterolone may increase the anticoagulant activities of Coumarin.
(R)-warfarin Mesterolone may increase the anticoagulant activities of (R)-warfarin.
Ethyl biscoumacetate Mesterolone may increase the anticoagulant activities of Ethyl biscoumacetate.
Fluindione Mesterolone may increase the anticoagulant activities of Fluindione.
Clorindione Mesterolone may increase the anticoagulant activities of Clorindione.
Diphenadione Mesterolone may increase the anticoagulant activities of Diphenadione.
Tioclomarol Mesterolone may increase the anticoagulant activities of Tioclomarol.
(S)-Warfarin Mesterolone may increase the anticoagulant activities of (S)-Warfarin.
Insulin human Mesterolone may increase the hypoglycemic activities of Insulin human.
Insulin lispro Mesterolone may increase the hypoglycemic activities of Insulin lispro.
Insulin glargine Mesterolone may increase the hypoglycemic activities of Insulin glargine.
Insulin pork Mesterolone may increase the hypoglycemic activities of Insulin pork.
Troglitazone Mesterolone may increase the hypoglycemic activities of Troglitazone.
Glimepiride Mesterolone may increase the hypoglycemic activities of Glimepiride.
Sulfisoxazole Mesterolone may increase the hypoglycemic activities of Sulfisoxazole.
Disopyramide Mesterolone may increase the hypoglycemic activities of Disopyramide.
Acarbose Mesterolone may increase the hypoglycemic activities of Acarbose.
Metformin Mesterolone may increase the hypoglycemic activities of Metformin.
Sulfadiazine Mesterolone may increase the hypoglycemic activities of Sulfadiazine.
Rosiglitazone Mesterolone may increase the hypoglycemic activities of Rosiglitazone.
Acetohexamide Mesterolone may increase the hypoglycemic activities of Acetohexamide.
Quinine Mesterolone may increase the hypoglycemic activities of Quinine.
Miglitol Mesterolone may increase the hypoglycemic activities of Miglitol.
Chlorpropamide Mesterolone may increase the hypoglycemic activities of Chlorpropamide.
Nateglinide Mesterolone may increase the hypoglycemic activities of Nateglinide.
Pentamidine Mesterolone may increase the hypoglycemic activities of Pentamidine.
Mifepristone Mesterolone may increase the hypoglycemic activities of Mifepristone.
Tolazamide Mesterolone may increase the hypoglycemic activities of Tolazamide.
Repaglinide Mesterolone may increase the hypoglycemic activities of Repaglinide.
Phenformin Mesterolone may increase the hypoglycemic activities of Phenformin.
Sulfamethoxazole Mesterolone may increase the hypoglycemic activities of Sulfamethoxazole.
Glyburide Mesterolone may increase the hypoglycemic activities of Glyburide.
Glipizide Mesterolone may increase the hypoglycemic activities of Glipizide.
Gliclazide Mesterolone may increase the hypoglycemic activities of Gliclazide.
Tolbutamide Mesterolone may increase the hypoglycemic activities of Tolbutamide.
Pioglitazone Mesterolone may increase the hypoglycemic activities of Pioglitazone.
Bromocriptine Mesterolone may increase the hypoglycemic activities of Bromocriptine.
Gliquidone Mesterolone may increase the hypoglycemic activities of Gliquidone.
Mitiglinide Mesterolone may increase the hypoglycemic activities of Mitiglinide.
Sitagliptin Mesterolone may increase the hypoglycemic activities of Sitagliptin.
Sunitinib Mesterolone may increase the hypoglycemic activities of Sunitinib.
Exenatide Mesterolone may increase the hypoglycemic activities of Exenatide.
Mecasermin Mesterolone may increase the hypoglycemic activities of Mecasermin.
Pramlintide Mesterolone may increase the hypoglycemic activities of Pramlintide.
Glisoxepide Mesterolone may increase the hypoglycemic activities of Glisoxepide.
Insulin aspart Mesterolone may increase the hypoglycemic activities of Insulin aspart.
Insulin detemir Mesterolone may increase the hypoglycemic activities of Insulin detemir.
Insulin glulisine Mesterolone may increase the hypoglycemic activities of Insulin glulisine.
Glymidine Mesterolone may increase the hypoglycemic activities of Glymidine.
AICA ribonucleotide Mesterolone may increase the hypoglycemic activities of AICA ribonucleotide.
Buformin Mesterolone may increase the hypoglycemic activities of Buformin.
Vildagliptin Mesterolone may increase the hypoglycemic activities of Vildagliptin.
Voglibose Mesterolone may increase the hypoglycemic activities of Voglibose.
NN344 Mesterolone may increase the hypoglycemic activities of NN344.
AMG-222 Mesterolone may increase the hypoglycemic activities of AMG-222.
Bisegliptin Mesterolone may increase the hypoglycemic activities of Bisegliptin.
Alogliptin Mesterolone may increase the hypoglycemic activities of Alogliptin.
Dapagliflozin Mesterolone may increase the hypoglycemic activities of Dapagliflozin.
Saxagliptin Mesterolone may increase the hypoglycemic activities of Saxagliptin.
Liraglutide Mesterolone may increase the hypoglycemic activities of Liraglutide.
Gosogliptin Mesterolone may increase the hypoglycemic activities of Gosogliptin.
Linagliptin Mesterolone may increase the hypoglycemic activities of Linagliptin.
Canagliflozin Mesterolone may increase the hypoglycemic activities of Canagliflozin.
Glibornuride Mesterolone may increase the hypoglycemic activities of Glibornuride.
Benfluorex Mesterolone may increase the hypoglycemic activities of Benfluorex.
Empagliflozin Mesterolone may increase the hypoglycemic activities of Empagliflozin.
Albiglutide Mesterolone may increase the hypoglycemic activities of Albiglutide.
Dulaglutide Mesterolone may increase the hypoglycemic activities of Dulaglutide.
Lobeglitazone Mesterolone may increase the hypoglycemic activities of Lobeglitazone.
Netoglitazone Mesterolone may increase the hypoglycemic activities of Netoglitazone.
Rivoglitazone Mesterolone may increase the hypoglycemic activities of Rivoglitazone.
Ciglitazone Mesterolone may increase the hypoglycemic activities of Ciglitazone.
Lixisenatide Mesterolone may increase the hypoglycemic activities of Lixisenatide.
Insulin beef Mesterolone may increase the hypoglycemic activities of Insulin beef.
Insulin degludec Mesterolone may increase the hypoglycemic activities of Insulin degludec.
Insulin peglispro Mesterolone may increase the hypoglycemic activities of Insulin peglispro.
Insulin tregopil Mesterolone may increase the hypoglycemic activities of Insulin tregopil.
Ipragliflozin Mesterolone may increase the hypoglycemic activities of Ipragliflozin.
Dutogliptin Mesterolone may increase the hypoglycemic activities of Dutogliptin.
Allicin Mesterolone may increase the hypoglycemic activities of Allicin.
Tofogliflozin Mesterolone may increase the hypoglycemic activities of Tofogliflozin.
Ertugliflozin Mesterolone may increase the hypoglycemic activities of Ertugliflozin.
2,4-thiazolidinedione Mesterolone may increase the hypoglycemic activities of 2,4-thiazolidinedione.
Teneligliptin Mesterolone may increase the hypoglycemic activities of Teneligliptin.
Omarigliptin Mesterolone may increase the hypoglycemic activities of Omarigliptin.
Carmegliptin Mesterolone may increase the hypoglycemic activities of Carmegliptin.
Gemigliptin Mesterolone may increase the hypoglycemic activities of Gemigliptin.
Anagliptin Mesterolone may increase the hypoglycemic activities of Anagliptin.
Evogliptin Mesterolone may increase the hypoglycemic activities of Evogliptin.
Sotagliflozin Mesterolone may increase the hypoglycemic activities of Sotagliflozin.
Balaglitazone Mesterolone may increase the hypoglycemic activities of Balaglitazone.
Remogliflozin etabonate Mesterolone may increase the hypoglycemic activities of Remogliflozin etabonate.
Carbutamide Mesterolone may increase the hypoglycemic activities of Carbutamide.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 872444
    Jackaman FR, Ansell ID, Ghanadian R, McLoughlin PV, Lewis JG, Chisholm GD: The hormone response to a synthetic androgen (mesterolone) in oligospermia. Clin Endocrinol (Oxf). 1977 May;6(5):339-45.
  • PMID: 2892728
    Varma TR, Patel RH: The effect of mesterolone on sperm count, on serum follicle stimulating hormone, luteinizing hormone, plasma testosterone and outcome in idiopathic oligospermic men. Int J Gynaecol Obstet. 1988 Feb;26(1):121-8.

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