Metergoline

DB13520

small molecule approved

Deskripsi

Metergoline is an ergot-derived psychoactive drug that acts as a ligand for serotonin and dopamine receptors. Metergoline is an antagonist at various 5-HT receptor subtypes at a relatively low concentration and agonist at dopamine receptors.A27181 Its use has been studied in various clinical settings such as a treatment for seasonal affective disorder, prolactin hormone regulation due to its inhibitory effect on prolactin release,A27182 premenstrual dysphoric disorder in women and antianxiety treatment.A27183

Struktur Molekul 2D

Berat 403.526
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1165 Data
Valsartan Metergoline may decrease the antihypertensive activities of Valsartan.
Ramipril Metergoline may decrease the antihypertensive activities of Ramipril.
Remikiren Metergoline may decrease the antihypertensive activities of Remikiren.
Torasemide Metergoline may decrease the antihypertensive activities of Torasemide.
Guanadrel Metergoline may decrease the antihypertensive activities of Guanadrel.
Isradipine Metergoline may decrease the antihypertensive activities of Isradipine.
Olmesartan Metergoline may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Metergoline may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Metergoline may decrease the antihypertensive activities of Nitroprusside.
Diltiazem Metergoline may decrease the antihypertensive activities of Diltiazem.
Minoxidil Metergoline may decrease the antihypertensive activities of Minoxidil.
Treprostinil Metergoline may decrease the antihypertensive activities of Treprostinil.
Amlodipine Metergoline may decrease the antihypertensive activities of Amlodipine.
Nimodipine Metergoline may decrease the antihypertensive activities of Nimodipine.
Nisoldipine Metergoline may decrease the antihypertensive activities of Nisoldipine.
Bendroflumethiazide Metergoline may decrease the antihypertensive activities of Bendroflumethiazide.
Prazosin Metergoline may decrease the antihypertensive activities of Prazosin.
Fosinopril Metergoline may decrease the antihypertensive activities of Fosinopril.
Trandolapril Metergoline may decrease the antihypertensive activities of Trandolapril.
Metolazone Metergoline may decrease the antihypertensive activities of Metolazone.
Lercanidipine Metergoline may decrease the antihypertensive activities of Lercanidipine.
Benazepril Metergoline may decrease the antihypertensive activities of Benazepril.
Bosentan Metergoline may decrease the antihypertensive activities of Bosentan.
Enalapril Metergoline may decrease the antihypertensive activities of Enalapril.
Doxazosin Metergoline may decrease the antihypertensive activities of Doxazosin.
Cyclothiazide Metergoline may decrease the antihypertensive activities of Cyclothiazide.
Candoxatril Metergoline may decrease the antihypertensive activities of Candoxatril.
Mecamylamine Metergoline may decrease the antihypertensive activities of Mecamylamine.
Losartan Metergoline may decrease the antihypertensive activities of Losartan.
Moexipril Metergoline may decrease the antihypertensive activities of Moexipril.
Eplerenone Metergoline may decrease the antihypertensive activities of Eplerenone.
Lisinopril Metergoline may decrease the antihypertensive activities of Lisinopril.
Hydroflumethiazide Metergoline may decrease the antihypertensive activities of Hydroflumethiazide.
Cryptenamine Metergoline may decrease the antihypertensive activities of Cryptenamine.
Perindopril Metergoline may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Metergoline may decrease the antihypertensive activities of Candesartan cilexetil.
Indapamide Metergoline may decrease the antihypertensive activities of Indapamide.
Tadalafil Metergoline may decrease the antihypertensive activities of Tadalafil.
Eprosartan Metergoline may decrease the antihypertensive activities of Eprosartan.
Chlorothiazide Metergoline may decrease the antihypertensive activities of Chlorothiazide.
Quinapril Metergoline may decrease the antihypertensive activities of Quinapril.
Telmisartan Metergoline may decrease the antihypertensive activities of Telmisartan.
Hydrochlorothiazide Metergoline may decrease the antihypertensive activities of Hydrochlorothiazide.
Trichlormethiazide Metergoline may decrease the antihypertensive activities of Trichlormethiazide.
Irbesartan Metergoline may decrease the antihypertensive activities of Irbesartan.
Nitrendipine Metergoline may decrease the antihypertensive activities of Nitrendipine.
Deserpidine Metergoline may decrease the antihypertensive activities of Deserpidine.
Pentolinium Metergoline may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Metergoline may decrease the antihypertensive activities of Trimethaphan.
Diazoxide Metergoline may decrease the antihypertensive activities of Diazoxide.
Bretylium Metergoline may decrease the antihypertensive activities of Bretylium.
Terazosin Metergoline may decrease the antihypertensive activities of Terazosin.
Guanethidine Metergoline may decrease the antihypertensive activities of Guanethidine.
Captopril Metergoline may decrease the antihypertensive activities of Captopril.
Epoprostenol Metergoline may decrease the antihypertensive activities of Epoprostenol.
Bepridil Metergoline may decrease the antihypertensive activities of Bepridil.
Hydralazine Metergoline may decrease the antihypertensive activities of Hydralazine.
Polythiazide Metergoline may decrease the antihypertensive activities of Polythiazide.
Cilazapril Metergoline may decrease the antihypertensive activities of Cilazapril.
Saprisartan Metergoline may decrease the antihypertensive activities of Saprisartan.
Spirapril Metergoline may decrease the antihypertensive activities of Spirapril.
Mibefradil Metergoline may decrease the antihypertensive activities of Mibefradil.
Tienilic acid Metergoline may decrease the antihypertensive activities of Tienilic acid.
Debrisoquine Metergoline may decrease the antihypertensive activities of Debrisoquine.
Sitaxentan Metergoline may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Metergoline may decrease the antihypertensive activities of Ambrisentan.
Diethylnorspermine Metergoline may decrease the antihypertensive activities of Diethylnorspermine.
Nilvadipine Metergoline may decrease the antihypertensive activities of Nilvadipine.
Pinacidil Metergoline may decrease the antihypertensive activities of Pinacidil.
Temocapril Metergoline may decrease the antihypertensive activities of Temocapril.
Riociguat Metergoline may decrease the antihypertensive activities of Riociguat.
Macitentan Metergoline may decrease the antihypertensive activities of Macitentan.
Aliskiren Metergoline may decrease the antihypertensive activities of Aliskiren.
Trimazosin Metergoline may decrease the antihypertensive activities of Trimazosin.
Nicorandil Metergoline may decrease the antihypertensive activities of Nicorandil.
Efonidipine Metergoline may decrease the antihypertensive activities of Efonidipine.
Lacidipine Metergoline may decrease the antihypertensive activities of Lacidipine.
Manidipine Metergoline may decrease the antihypertensive activities of Manidipine.
Niguldipine Metergoline may decrease the antihypertensive activities of Niguldipine.
Rauwolfia serpentina root Metergoline may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Metergoline may decrease the antihypertensive activities of Enalaprilat.
Selexipag Metergoline may decrease the antihypertensive activities of Selexipag.
Angiotensin 1-7 Metergoline may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Metergoline may decrease the antihypertensive activities of Imidapril.
BQ-123 Metergoline may decrease the antihypertensive activities of BQ-123.
Cicletanine Metergoline may decrease the antihypertensive activities of Cicletanine.
Dihydralazine Metergoline may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Metergoline may decrease the antihypertensive activities of Zofenopril.
Guanoxan Metergoline may decrease the antihypertensive activities of Guanoxan.
Delapril Metergoline may decrease the antihypertensive activities of Delapril.
Vincamine Metergoline may decrease the antihypertensive activities of Vincamine.
Linsidomine Metergoline may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Metergoline may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Metergoline may decrease the antihypertensive activities of Tolonidine.
Endralazine Metergoline may decrease the antihypertensive activities of Endralazine.
Cadralazine Metergoline may decrease the antihypertensive activities of Cadralazine.
Cyclopenthiazide Metergoline may decrease the antihypertensive activities of Cyclopenthiazide.
Bietaserpine Metergoline may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Metergoline may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Metergoline may decrease the antihypertensive activities of Methoserpidine.

Target Protein

5-hydroxytryptamine receptor 2C HTR2C
5-hydroxytryptamine receptor 1B HTR1B
5-hydroxytryptamine receptor 1E HTR1E
5-hydroxytryptamine receptor 1F HTR1F
5-hydroxytryptamine receptor 5A HTR5A
5-hydroxytryptamine receptor 1D HTR1D
5-hydroxytryptamine receptor 2B HTR2B
5-hydroxytryptamine receptor 2A HTR2A
Sodium channel protein type 2 subunit alpha SCN2A

Referensi & Sumber

Artikel (PubMed)
  • PMID: 578618
    Delitala G: Stimulating action of sulpiride and pimozide on prolactin release. Effect on bromocriptine, L-dopa and metergoline administration. Acta Endocrinol (Copenh). 1977 Oct;86(2):251-6.
  • PMID: 3929304
    Graeff FG, Zuardi AW, Giglio JS, Lima Filho EC, Karniol IG: Effect of metergoline on human anxiety. Psychopharmacology (Berl). 1985;86(3):334-8.
  • PMID: 24909513
    Lee JH, Liu J, Shin M, Hong M, Nah SY, Bae H: Metergoline inhibits the neuronal Nav1.2 voltage-dependent Na(+) channels expressed in Xenopus oocytes. Acta Pharmacol Sin. 2014 Jul;35(7):862-8. doi: 10.1038/aps.2014.30. Epub 2014 Jun 9.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
  • Liserdol

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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