Peringatan Keamanan

Probable oral lethal dose reported in humans is above 15 g/kg L2695. Ingestion of large quantities may result in abdominal distension, intestinal obstruction, nausea, vomiting, and difficulty swallowing. Aspiration or inhalation may lead to pneumonitis L2695. In the event of overdosage symptomatic treatment should be given F46.

Alginic acid

DB13518

small molecule approved investigational

Deskripsi

Alginic acid, also referred to as algin or alginate, is a hydrophilic or anionic polysaccharide isolated from certain brown seaweed (Phacophycae) via alkaline extraction. It is present in cell walls of brown algae where it forms a viscous gel when binding with water. Alginic acid is a linear polymer consisted of L-glucuronic acid and D-mannuronic acid residues connected via 1,4-glycosidic linkages A32961. Available in different types of salt, alginic acid has been used in a variety of uses in food, cosmetics and pharmaceu-tical products for over 100 years A32961. Alginic acid is an FDA-approved food ingredient in soup and soup mixes as an emulsifier, thickener, and stabilizer L2693. It is also available in oral dietary supplements and is found in antacids such as Gaviscon to inhibit gastroesophageal reflux by creating a physical barrier in presence of gastric acid F46. Alginate-based raft-forming formulations in the management of heartburn and gastric acid reflux have been used worldwide for over 30 years A32961.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) This pharmacokinetic parameter is unlikely to apply for alginic acid.
Volume Distribusi This pharmacokinetic parameter is unlikely to apply for alginic acid.
Klirens (Clearance) This pharmacokinetic parameter is unlikely to apply for alginic acid.

Absorpsi

The absorption into the systemic circulation from oral formulations of alginic acid is reported to be minimal, as the mode of action of alginic acid is physical F46.

Metabolisme

This pharmacokinetic parameter is unlikely to apply for alginic acid.

Rute Eliminasi

This pharmacokinetic parameter is unlikely to apply for alginic acid.

Interaksi Obat

0 Data
Tidak ada data.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 1551350
    Castell DO, Dalton CB, Becker D, Sinclair J, Castell JA: Alginic acid decreases postprandial upright gastroesophageal reflux. Comparison with equal-strength antacid. Dig Dis Sci. 1992 Apr;37(4):589-93.
  • PMID: 231639
    Malmud LS, Charkes ND, Littlefield J, Reilley J, Stern H, Rosenberg R, Fisher RS: The mode of action alginic acid compound in the reduction of gastroesophageal reflux. J Nucl Med. 1979 Oct;20(10):1023-8.
  • PMID: 27671545
    Leiman DA, Riff BP, Morgan S, Metz DC, Falk GW, French B, Umscheid CA, Lewis JD: Alginate therapy is effective treatment for gastroesophageal reflux disease symptoms: a systematic review and meta-analysis. Dis Esophagus. 2017 Feb 1;30(2):1-8. doi: 10.1111/dote.12535.
  • PMID: 10848650
    Mandel KG, Daggy BP, Brodie DA, Jacoby HI: Review article: alginate-raft formulations in the treatment of heartburn and acid reflux. Aliment Pharmacol Ther. 2000 Jun;14(6):669-90.

Contoh Produk & Brand

Produk: 24 • International brands: 0
Produk
  • axSAN
    Capsule • - • Oral • US
  • Gastrocote Chewable Tab
    Tablet • - • Oral • Canada • OTC • Approved
  • Gaviscon Butterscotch Flavour Tablets
    Tablet • - • Oral • Canada • OTC • Approved
  • Gaviscon Extra Strength Butterscotch Flavoured Tablets
    Tablet • - • Oral • Canada • OTC • Approved
  • Gaviscon Extra Strength Strawberry Fl.tabs
    Tablet • - • Oral • Canada • OTC • Approved
  • Gaviscon Extra Strength Tablets
    Tablet • - • Oral • Canada • OTC • Approved
  • Gaviscon Heartburn Relief Liquid
    Liquid • - • Oral • Canada • OTC • Approved
  • Gaviscon Heartburn Relief Tablets
    Tablet • - • Oral • Canada • OTC • Approved
Menampilkan 8 dari 24 produk.

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