The components of tyrothricin are capable of disrupting eukaryotic cell membranes at high concentrations resulting in toxicity A32878. This manifests as hemolysis in systemic administration. It is thought that the cholesterol present in eukaryotic cells affords some resistance to the toxic mechanisms of tyrothricin A32877. Loss of olfactory function has been noted and topical administration to the nasal mucous membranes is not recommended A32843.
Tyrothricin is an antibiotic peptide complex produced and extracted from the aerobic Gram-positive bacillus Brevibacillus parabrevis L4019, L4021, A32851 which was previously categorized as Bacillus brevis and Bacillus aneurinolyticus A36353. This complex is a mixture comprised of 60% tyrocidine cationic cyclic decapeptides (consisting largely of the six predominant tyrocidines, TrcA/A1, TrcB/B1, TrcC/C1, and other more minor contributors) and 40% neutral linear gramicidins (where valine-gramicidin A is often the major gramicidin present, although the mixture composition can vary) L4019, L4021, L4022. Moreover, tyrothricin possesses broad spectrum Gram-positive antibacterial and antifungal activity that has not seen many - if any - significant reportings of microbial resistance during the over 60 years of therapeutic use the complex has provided A36360. Nevertheless, as tyrothricin is both cytolytic and hemolytic, it does demonstrate systemic toxicity L4019, L4021, L4022, although certain formulations that are safe for human use like throat lozenges do exist L4028.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Dipyridamole | The therapeutic efficacy of Tyrothricin can be decreased when used in combination with Dipyridamole. |
| Ephedrine | Tyrothricin may increase the neuromuscular blocking activities of Ephedrine. |
| Bambuterol | Tyrothricin may increase the neuromuscular blocking activities of Bambuterol. |
| Clevidipine | Tyrothricin may increase the neuromuscular blocking activities of Clevidipine. |
| Sar9, Met (O2)11-Substance P | Tyrothricin may increase the neuromuscular blocking activities of Sar9, Met (O2)11-Substance P. |
| Mirabegron | Tyrothricin may increase the neuromuscular blocking activities of Mirabegron. |
| Moxisylyte | Tyrothricin may increase the neuromuscular blocking activities of Moxisylyte. |
| Propacetamol | Tyrothricin may increase the neuromuscular blocking activities of Propacetamol. |
| Procaine | The risk or severity of methemoglobinemia can be increased when Tyrothricin is combined with Procaine. |
| Cocaine | The risk or severity of methemoglobinemia can be increased when Tyrothricin is combined with Cocaine. |
| Trimethaphan | Tyrothricin may increase the neuromuscular blocking activities of Trimethaphan. |
| Doxacurium | Tyrothricin may increase the neuromuscular blocking activities of Doxacurium. |
| Chloroprocaine | The risk or severity of methemoglobinemia can be increased when Tyrothricin is combined with Chloroprocaine. |
| Tubocurarine | Tyrothricin may increase the neuromuscular blocking activities of Tubocurarine. |
| Aclidinium | Tyrothricin may increase the neuromuscular blocking activities of Aclidinium. |
| Butyrylthiocholine | Tyrothricin may increase the neuromuscular blocking activities of Butyrylthiocholine. |
| Oxybuprocaine | The risk or severity of methemoglobinemia can be increased when Tyrothricin is combined with Oxybuprocaine. |
| Benzonatate | Tyrothricin may increase the neuromuscular blocking activities of Benzonatate. |
| Succinylcholine | The metabolism of Succinylcholine can be decreased when combined with Tyrothricin. |
| Picosulfuric acid | The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Tyrothricin. |
| Tramadol | The therapeutic efficacy of Tramadol can be decreased when used in combination with Tyrothricin. |
| Trospium | The therapeutic efficacy of Trospium can be decreased when used in combination with Tyrothricin. |
| Oxyphenonium | The therapeutic efficacy of Oxyphenonium can be decreased when used in combination with Tyrothricin. |
| Butabarbital | The therapeutic efficacy of Butabarbital can be decreased when used in combination with Tyrothricin. |
| Butalbital | The therapeutic efficacy of Butalbital can be decreased when used in combination with Tyrothricin. |
| Benzatropine | The therapeutic efficacy of Benzatropine can be decreased when used in combination with Tyrothricin. |
| Ziprasidone | The therapeutic efficacy of Ziprasidone can be decreased when used in combination with Tyrothricin. |
| Disopyramide | The therapeutic efficacy of Disopyramide can be decreased when used in combination with Tyrothricin. |
| Talbutal | The therapeutic efficacy of Talbutal can be decreased when used in combination with Tyrothricin. |
| Pentobarbital | The therapeutic efficacy of Pentobarbital can be decreased when used in combination with Tyrothricin. |
| Amitriptyline | The therapeutic efficacy of Amitriptyline can be decreased when used in combination with Tyrothricin. |
| Ipratropium | The therapeutic efficacy of Ipratropium can be decreased when used in combination with Tyrothricin. |
| Methadone | The therapeutic efficacy of Methadone can be decreased when used in combination with Tyrothricin. |
| Olanzapine | The therapeutic efficacy of Olanzapine can be decreased when used in combination with Tyrothricin. |
| Metixene | The therapeutic efficacy of Metixene can be decreased when used in combination with Tyrothricin. |
| Terfenadine | The therapeutic efficacy of Terfenadine can be decreased when used in combination with Tyrothricin. |
| Buclizine | The therapeutic efficacy of Buclizine can be decreased when used in combination with Tyrothricin. |
| Clozapine | The therapeutic efficacy of Clozapine can be decreased when used in combination with Tyrothricin. |
| Doxylamine | The therapeutic efficacy of Doxylamine can be decreased when used in combination with Tyrothricin. |
| Trihexyphenidyl | The therapeutic efficacy of Trihexyphenidyl can be decreased when used in combination with Tyrothricin. |
| Oxyphencyclimine | The therapeutic efficacy of Oxyphencyclimine can be decreased when used in combination with Tyrothricin. |
| Procyclidine | The therapeutic efficacy of Procyclidine can be decreased when used in combination with Tyrothricin. |
| Profenamine | The therapeutic efficacy of Profenamine can be decreased when used in combination with Tyrothricin. |
| Secobarbital | The therapeutic efficacy of Secobarbital can be decreased when used in combination with Tyrothricin. |
| Promazine | The therapeutic efficacy of Promazine can be decreased when used in combination with Tyrothricin. |
| Hyoscyamine | The therapeutic efficacy of Hyoscyamine can be decreased when used in combination with Tyrothricin. |
| Cyproheptadine | The therapeutic efficacy of Cyproheptadine can be decreased when used in combination with Tyrothricin. |
| Imipramine | The therapeutic efficacy of Imipramine can be decreased when used in combination with Tyrothricin. |
| Methscopolamine bromide | The therapeutic efficacy of Methscopolamine bromide can be decreased when used in combination with Tyrothricin. |
| Metharbital | The therapeutic efficacy of Metharbital can be decreased when used in combination with Tyrothricin. |
| Fluoxetine | The therapeutic efficacy of Fluoxetine can be decreased when used in combination with Tyrothricin. |
| Chlorpromazine | The therapeutic efficacy of Chlorpromazine can be decreased when used in combination with Tyrothricin. |
| Darifenacin | The therapeutic efficacy of Darifenacin can be decreased when used in combination with Tyrothricin. |
| Tridihexethyl | The therapeutic efficacy of Tridihexethyl can be decreased when used in combination with Tyrothricin. |
| Triflupromazine | The therapeutic efficacy of Triflupromazine can be decreased when used in combination with Tyrothricin. |
| Dextromethorphan | The therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Tyrothricin. |
| Anisotropine methylbromide | The therapeutic efficacy of Anisotropine methylbromide can be decreased when used in combination with Tyrothricin. |
| Nortriptyline | The therapeutic efficacy of Nortriptyline can be decreased when used in combination with Tyrothricin. |
| Amoxapine | The therapeutic efficacy of Amoxapine can be decreased when used in combination with Tyrothricin. |
| Atropine | The therapeutic efficacy of Atropine can be decreased when used in combination with Tyrothricin. |
| Thiopental | The therapeutic efficacy of Thiopental can be decreased when used in combination with Tyrothricin. |
| Nicardipine | The therapeutic efficacy of Nicardipine can be decreased when used in combination with Tyrothricin. |
| Mecamylamine | The therapeutic efficacy of Mecamylamine can be decreased when used in combination with Tyrothricin. |
| Pirenzepine | The therapeutic efficacy of Pirenzepine can be decreased when used in combination with Tyrothricin. |
| Paroxetine | The therapeutic efficacy of Paroxetine can be decreased when used in combination with Tyrothricin. |
| Homatropine methylbromide | The therapeutic efficacy of Homatropine methylbromide can be decreased when used in combination with Tyrothricin. |
| Scopolamine | The therapeutic efficacy of Scopolamine can be decreased when used in combination with Tyrothricin. |
| Isoflurane | The therapeutic efficacy of Isoflurane can be decreased when used in combination with Tyrothricin. |
| Benzquinamide | The therapeutic efficacy of Benzquinamide can be decreased when used in combination with Tyrothricin. |
| Clidinium | The therapeutic efficacy of Clidinium can be decreased when used in combination with Tyrothricin. |
| Propiomazine | The therapeutic efficacy of Propiomazine can be decreased when used in combination with Tyrothricin. |
| Propantheline | The therapeutic efficacy of Propantheline can be decreased when used in combination with Tyrothricin. |
| Primidone | The therapeutic efficacy of Primidone can be decreased when used in combination with Tyrothricin. |
| Dicyclomine | The therapeutic efficacy of Dicyclomine can be decreased when used in combination with Tyrothricin. |
| Biperiden | The therapeutic efficacy of Biperiden can be decreased when used in combination with Tyrothricin. |
| Brompheniramine | The therapeutic efficacy of Brompheniramine can be decreased when used in combination with Tyrothricin. |
| Methylphenobarbital | The therapeutic efficacy of Methylphenobarbital can be decreased when used in combination with Tyrothricin. |
| Quinidine | The therapeutic efficacy of Quinidine can be decreased when used in combination with Tyrothricin. |
| Amantadine | The therapeutic efficacy of Amantadine can be decreased when used in combination with Tyrothricin. |
| Maprotiline | The therapeutic efficacy of Maprotiline can be decreased when used in combination with Tyrothricin. |
| Methantheline | The therapeutic efficacy of Methantheline can be decreased when used in combination with Tyrothricin. |
| Hexafluronium | The therapeutic efficacy of Hexafluronium can be decreased when used in combination with Tyrothricin. |
| Cycrimine | The therapeutic efficacy of Cycrimine can be decreased when used in combination with Tyrothricin. |
| Desloratadine | The therapeutic efficacy of Desloratadine can be decreased when used in combination with Tyrothricin. |
| Glycopyrronium | The therapeutic efficacy of Glycopyrronium can be decreased when used in combination with Tyrothricin. |
| Tolterodine | The therapeutic efficacy of Tolterodine can be decreased when used in combination with Tyrothricin. |
| Oxybutynin | The therapeutic efficacy of Oxybutynin can be decreased when used in combination with Tyrothricin. |
| Promethazine | The therapeutic efficacy of Promethazine can be decreased when used in combination with Tyrothricin. |
| Diphenhydramine | The risk or severity of methemoglobinemia can be increased when Tyrothricin is combined with Diphenhydramine. |
| Pentolinium | The therapeutic efficacy of Pentolinium can be decreased when used in combination with Tyrothricin. |
| Doxepin | The therapeutic efficacy of Doxepin can be decreased when used in combination with Tyrothricin. |
| Flavoxate | The therapeutic efficacy of Flavoxate can be decreased when used in combination with Tyrothricin. |
| Desipramine | The therapeutic efficacy of Desipramine can be decreased when used in combination with Tyrothricin. |
| Orphenadrine | The therapeutic efficacy of Orphenadrine can be decreased when used in combination with Tyrothricin. |
| Phenobarbital | The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Tyrothricin. |
| Escitalopram | The therapeutic efficacy of Escitalopram can be decreased when used in combination with Tyrothricin. |
| Quetiapine | The therapeutic efficacy of Quetiapine can be decreased when used in combination with Tyrothricin. |
| Levacetylmethadol | The therapeutic efficacy of Levacetylmethadol can be decreased when used in combination with Tyrothricin. |
| Diphenidol | The therapeutic efficacy of Diphenidol can be decreased when used in combination with Tyrothricin. |
| Aripiprazole | The therapeutic efficacy of Aripiprazole can be decreased when used in combination with Tyrothricin. |