Otilonium

DB13500

small molecule experimental investigational

Deskripsi

Struktur Molekul 2D

Berat 483.672
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1302 Data
Ceritinib Otilonium may increase the bradycardic activities of Ceritinib.
Ivabradine Otilonium may increase the bradycardic activities of Ivabradine.
Ruxolitinib Ruxolitinib may increase the bradycardic activities of Otilonium.
Aclidinium The risk or severity of adverse effects can be increased when Otilonium is combined with Aclidinium.
Mianserin Mianserin may increase the anticholinergic activities of Otilonium.
Mirabegron The risk or severity of urinary retention can be increased when Otilonium is combined with Mirabegron.
Pramlintide The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Otilonium.
Secretin porcine The therapeutic efficacy of Secretin porcine can be decreased when used in combination with Otilonium.
Tiotropium The risk or severity of adverse effects can be increased when Otilonium is combined with Tiotropium.
Topiramate The risk or severity of hyperthermia and oligohydrosis can be increased when Otilonium is combined with Topiramate.
Umeclidinium The risk or severity of adverse effects can be increased when Otilonium is combined with Umeclidinium.
Cimetidine The serum concentration of Otilonium can be increased when it is combined with Cimetidine.
Clopidogrel The therapeutic efficacy of Clopidogrel can be decreased when used in combination with Otilonium.
Efavirenz The serum concentration of Otilonium can be decreased when it is combined with Efavirenz.
Melatonin The therapeutic efficacy of Otilonium can be decreased when used in combination with Melatonin.
Nafcillin The therapeutic efficacy of Otilonium can be decreased when used in combination with Nafcillin.
Nitroprusside Otilonium may increase the hypotensive activities of Nitroprusside.
Dantrolene The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Otilonium.
Lithium citrate The risk or severity of adverse effects can be increased when Otilonium is combined with Lithium citrate.
Lithium carbonate The risk or severity of adverse effects can be increased when Otilonium is combined with Lithium carbonate.
Lithium hydroxide The risk or severity of adverse effects can be increased when Otilonium is combined with Lithium hydroxide.
Glycopyrronium The risk or severity of adverse effects can be increased when Otilonium is combined with Glycopyrronium.
Boceprevir The serum concentration of Otilonium can be increased when it is combined with Boceprevir.
Botulinum toxin type A The risk or severity of adverse effects can be increased when Otilonium is combined with Botulinum toxin type A.
Glucagon Otilonium may increase the gastrointestinal motility reducing activities of Glucagon.
Sulpiride Otilonium may increase the anticholinergic activities of Sulpiride.
Botulinum toxin type B The risk or severity of adverse effects can be increased when Otilonium is combined with Botulinum toxin type B.
Eluxadoline The risk or severity of constipation can be increased when Otilonium is combined with Eluxadoline.
Ramosetron The risk or severity of constipation can be increased when Otilonium is combined with Ramosetron.
Naltrexone The risk or severity of adverse effects can be increased when Otilonium is combined with Naltrexone.
Bezitramide The risk or severity of adverse effects can be increased when Otilonium is combined with Bezitramide.
Tramadol The risk or severity of adverse effects can be increased when Otilonium is combined with Tramadol.
Morphine The risk or severity of adverse effects can be increased when Otilonium is combined with Morphine.
Codeine The risk or severity of adverse effects can be increased when Otilonium is combined with Codeine.
Hydromorphone The risk or severity of adverse effects can be increased when Otilonium is combined with Hydromorphone.
Oxycodone The risk or severity of adverse effects can be increased when Otilonium is combined with Oxycodone.
Butorphanol The risk or severity of adverse effects can be increased when Otilonium is combined with Butorphanol.
Pentazocine The risk or severity of adverse effects can be increased when Otilonium is combined with Pentazocine.
Sufentanil The risk or severity of adverse effects can be increased when Otilonium is combined with Sufentanil.
Nalbuphine The risk or severity of adverse effects can be increased when Otilonium is combined with Nalbuphine.
Levorphanol The risk or severity of adverse effects can be increased when Otilonium is combined with Levorphanol.
Remifentanil The risk or severity of adverse effects can be increased when Otilonium is combined with Remifentanil.
Buprenorphine The risk or severity of adverse effects can be increased when Otilonium is combined with Buprenorphine.
Hydrocodone The risk or severity of adverse effects can be increased when Otilonium is combined with Hydrocodone.
Diphenoxylate The risk or severity of adverse effects can be increased when Otilonium is combined with Diphenoxylate.
Oxymorphone The risk or severity of adverse effects can be increased when Otilonium is combined with Oxymorphone.
Dezocine The risk or severity of adverse effects can be increased when Otilonium is combined with Dezocine.
Methadyl acetate The risk or severity of adverse effects can be increased when Otilonium is combined with Methadyl acetate.
Dihydroetorphine The risk or severity of adverse effects can be increased when Otilonium is combined with Dihydroetorphine.
Diamorphine The risk or severity of adverse effects can be increased when Otilonium is combined with Diamorphine.
Ethylmorphine The risk or severity of adverse effects can be increased when Otilonium is combined with Ethylmorphine.
Etorphine The risk or severity of adverse effects can be increased when Otilonium is combined with Etorphine.
Dextromoramide The risk or severity of adverse effects can be increased when Otilonium is combined with Dextromoramide.
Desomorphine The risk or severity of adverse effects can be increased when Otilonium is combined with Desomorphine.
Carfentanil The risk or severity of adverse effects can be increased when Otilonium is combined with Carfentanil.
Dihydrocodeine The risk or severity of adverse effects can be increased when Otilonium is combined with Dihydrocodeine.
Alphacetylmethadol The risk or severity of adverse effects can be increased when Otilonium is combined with Alphacetylmethadol.
Dihydromorphine The risk or severity of adverse effects can be increased when Otilonium is combined with Dihydromorphine.
Tapentadol The risk or severity of urinary retention and constipation can be increased when Otilonium is combined with Tapentadol.
Ketobemidone The risk or severity of adverse effects can be increased when Otilonium is combined with Ketobemidone.
DPDPE The risk or severity of adverse effects can be increased when Otilonium is combined with DPDPE.
Lofentanil The risk or severity of adverse effects can be increased when Otilonium is combined with Lofentanil.
Opium The risk or severity of adverse effects can be increased when Otilonium is combined with Opium.
Normethadone The risk or severity of adverse effects can be increased when Otilonium is combined with Normethadone.
Piritramide The risk or severity of adverse effects can be increased when Otilonium is combined with Piritramide.
Alphaprodine The risk or severity of adverse effects can be increased when Otilonium is combined with Alphaprodine.
Nicomorphine The risk or severity of adverse effects can be increased when Otilonium is combined with Nicomorphine.
Meptazinol The risk or severity of adverse effects can be increased when Otilonium is combined with Meptazinol.
Phenoperidine The risk or severity of adverse effects can be increased when Otilonium is combined with Phenoperidine.
Phenazocine The risk or severity of adverse effects can be increased when Otilonium is combined with Phenazocine.
Tilidine The risk or severity of adverse effects can be increased when Otilonium is combined with Tilidine.
Carfentanil, C-11 The risk or severity of adverse effects can be increased when Otilonium is combined with Carfentanil, C-11.
Methadone The risk or severity of adverse effects can be increased when Otilonium is combined with Methadone.
Benzhydrocodone The risk or severity of adverse effects can be increased when Otilonium is combined with Benzhydrocodone.
Levacetylmethadol The risk or severity of adverse effects can be increased when Otilonium is combined with Levacetylmethadol.
Alfentanil The risk or severity of adverse effects can be increased when Otilonium is combined with Alfentanil.
Fentanyl The risk or severity of adverse effects can be increased when Otilonium is combined with Fentanyl.
Meperidine The risk or severity of adverse effects can be increased when Otilonium is combined with Meperidine.
Dextropropoxyphene The risk or severity of adverse effects can be increased when Otilonium is combined with Dextropropoxyphene.
Naloxegol The risk or severity of adverse effects can be increased when Otilonium is combined with Naloxegol.
Trospium The risk or severity of adverse effects can be increased when Trospium is combined with Otilonium.
Oxyphenonium The risk or severity of adverse effects can be increased when Oxyphenonium is combined with Otilonium.
Metixene The risk or severity of adverse effects can be increased when Metixene is combined with Otilonium.
Trihexyphenidyl The risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Otilonium.
Oxyphencyclimine The risk or severity of adverse effects can be increased when Oxyphencyclimine is combined with Otilonium.
Procyclidine The risk or severity of adverse effects can be increased when Procyclidine is combined with Otilonium.
Methscopolamine bromide The risk or severity of adverse effects can be increased when Methscopolamine bromide is combined with Otilonium.
Tridihexethyl The risk or severity of adverse effects can be increased when Tridihexethyl is combined with Otilonium.
Anisotropine methylbromide The risk or severity of adverse effects can be increased when Anisotropine methylbromide is combined with Otilonium.
Mecamylamine The risk or severity of adverse effects can be increased when Mecamylamine is combined with Otilonium.
Pirenzepine The risk or severity of adverse effects can be increased when Pirenzepine is combined with Otilonium.
Homatropine methylbromide The risk or severity of adverse effects can be increased when Homatropine methylbromide is combined with Otilonium.
Benzquinamide The risk or severity of adverse effects can be increased when Benzquinamide is combined with Otilonium.
Propantheline The risk or severity of adverse effects can be increased when Propantheline is combined with Otilonium.
Dicyclomine The risk or severity of adverse effects can be increased when Dicyclomine is combined with Otilonium.
Tropicamide The risk or severity of adverse effects can be increased when Tropicamide is combined with Otilonium.
Methantheline The risk or severity of adverse effects can be increased when Methantheline is combined with Otilonium.
Cycrimine The risk or severity of adverse effects can be increased when Cycrimine is combined with Otilonium.
Cyclopentolate The risk or severity of adverse effects can be increased when Cyclopentolate is combined with Otilonium.
Pentolinium The risk or severity of adverse effects can be increased when Pentolinium is combined with Otilonium.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 29732965
    Evangelista S, Traini C, Vannucchi MG: Otilonium Bromide: A Drug with a Complex Mechanism of Action. Curr Pharm Des. 2018;24(16):1772-1779. doi: 10.2174/1381612824666180507122935.
  • PMID: 10689627
    Evangelista S: Otilonium bromide: a selective spasmolytic for the gastrointestinal tract. J Int Med Res. 1999 Sep-Oct;27(5):207-22. doi: 10.1177/030006059902700501.

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