Peringatan Keamanan

Ioxitalamate is reported to induce acute kidney injury.A33006 Preclinical studies showed that it does not present a teratogenic potential as well as a lack of effect on fertility.F55 Ioxitalamate overdose may increase the risk of nephropathy and cardiovascular disorders.F54

Ioxitalamic acid

DB13444

small molecule approved

Deskripsi

Ioxitalamate is an ionic iodinated contrast medium.A27209 It is a first-generation contrast media formed by an ionic monomer with a high osmolarity of 1500-1800 mOsm/kg.A33006 Ioxitalamic acid in the salt forms of sodium and meglumine was developed by Liebel-Flarshem Canada Inc and approved by Health Canada in 1995. Until the last review in 2015, this drug is still available in the market.L1113

Struktur Molekul 2D

Berat 643.942
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The elimination half-life of ioxitalamate is 1.1 hours.[F56]
Volume Distribusi The volume of distribution of ioxitalamate is 194 ml/kg.[F56]
Klirens (Clearance) The total clearance rate of ioxitalamate is 120 ml/min.[F56]

Absorpsi

When administered ioxitalamate is not absorbed in the GI tract. In the case of presence of an intestinal perforation, ioxitalamate is completely absorbed.F55 When administered intravascularly, ioxitalamate is rapidly distributed in the interstitial space and intravascular compartment.F56

Metabolisme

The rapid clearance suggests that ioxitalamate is not metabolized in the body.T197

Rute Eliminasi

As ioxitalamate is not absorbed in the normal intestine, the elimination route of this compound is entirely performed by the feces. When absorbed due to the presence of an intestinal perforation, ioxitalamate presents a rapid renal elimination.F55 when ioxitalamate is administered intravascularly, it is eliminated unchanged mainly via renal excretion through glomerular filtration without reabsorption or tubular secretion. In the cases of renal failure, the elimination is mainly performed in the biliary, salivary, sudoral and colic route.F56

Interaksi Obat

0 Data
Tidak ada data.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 23406968
    Kim KH, Kim YS, Kuh SU, Park HS, Park JY, Chin DK, Kim KS, Cho YE: Time- and dose-dependent cytotoxicities of ioxitalamate and indigocarmine in human nucleus pulposus cells. Spine J. 2013 May;13(5):564-71. doi: 10.1016/j.spinee.2013.01.019. Epub 2013 Feb 11.
  • PMID: 19945959
    Hsu SP, Tsai TJ, Chien CT: Ioxitalamate induces renal tubular apoptosis via activation of renal efferent nerve-mediated adrenergic signaling, renin activity, and reactive oxygen species production in rats. Toxicol Sci. 2010 Mar;114(1):149-58. doi: 10.1093/toxsci/kfp290. Epub 2009 Nov 26.
  • PMID: 23210836
    Lusic H, Grinstaff MW: X-ray-computed tomography contrast agents. Chem Rev. 2013 Mar 13;113(3):1641-66. doi: 10.1021/cr200358s. Epub 2012 Dec 5.
Textbook
  • ISBN: 978-3-642-46844-5
    Buthiau D. and Khayat D. (1995). CT and MRI in oncology. Springer-Verlag.
  • Seyffart G. (1992). Drug dosage in renal insufficiency (2nd ed.). Springer Science+Business Media Dordrecht.
  • ISBN: 978-0-8138-1753-8
    Coyne C. (2006). Comparative diagnostics pharmacology. Blackwell publishing.

Contoh Produk & Brand

Produk: 2 • International brands: 0
Produk
  • Telebrix 38 Oral
    Solution • - • Oral • Canada • Approved
  • Telebrix 38 Oral
    Solution • - • Oral • Canada • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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