Peringatan Keamanan

Fertility and mutagenicity studies do not indicate any effect driven by dichlorobenzyl alcohol.F71 Overdose studies indicate that in systemic overdose there might be a presence of a CNS transitory stimulation followed by CNS and cardiovascular. Chronic administration is not recommended as it might alter the normal microbial balance of the throat.F73 depression In rats, the reported LD50 is of about 2.7 g/kg when administered orally.F71

Dichlorobenzyl alcohol

DB13269

small molecule approved

Deskripsi

Dichlorobenzyl alcohol is a mild antiseptic with a broad spectrum for bacterial and virus associated with mouth and throat infections.A33047 Dichlorobenzyl alcohol is considered as an active ingredient found in several marketed OTC products by Health Canada which has categorized this agent as an anatomical therapeutic chemical.L1113 On the other hand, dichlorobenzyl alcohol is categorized by the FDA in the inactive ingredient for approved drug products.L2773

Struktur Molekul 2D

Berat 177.02
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) This pharmacokinetic property has not been fully studied.
Volume Distribusi This pharmacokinetic property has not been fully studied.
Klirens (Clearance) This pharmacokinetic property has not been fully studied.

Absorpsi

Dichlorobenzyl alcohol is released almost immediately from its formulation and reaches peak concentration after 3-4 minutes.F72 The concentration in saliva after 120 minutes represents about 50% of the administered dose.F73

Metabolisme

Dichlorobenzyl alcohol is metabolized in the liver to form hippuric acid.F74

Rute Eliminasi

In preclinical trials, dermal administration of dichlorobenzyl alcohol results in renal elimination of 90% of the administered dose.F72 After metabolism, dichlorobenzyl alcohol is excreted in the urine.F74

Interaksi Obat

725 Data
Cyclosporine Cyclosporine may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Icosapent Icosapent may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cefotiam Cefotiam may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Mesalazine Mesalazine may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cefmenoxime Cefmenoxime may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cefmetazole Cefmetazole may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Pamidronic acid Pamidronic acid may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Tenofovir disoproxil Tenofovir disoproxil may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Indomethacin Indomethacin may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cidofovir Cidofovir may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cefpiramide Cefpiramide may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Ceftazidime Ceftazidime may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Loracarbef Loracarbef may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cefalotin Cefalotin may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Nabumetone Nabumetone may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Ketorolac Ketorolac may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Tenoxicam Tenoxicam may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cefotaxime Cefotaxime may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Tolmetin Tolmetin may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Foscarnet Foscarnet may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Rofecoxib Rofecoxib may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Piroxicam Piroxicam may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Methotrexate Methotrexate may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cephalexin Cephalexin may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Fenoprofen Fenoprofen may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Valaciclovir Valaciclovir may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Valdecoxib Valdecoxib may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Diclofenac Diclofenac may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Sulindac Sulindac may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Bacitracin Bacitracin may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Amphotericin B Amphotericin B may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cephaloglycin Cephaloglycin may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Flurbiprofen Flurbiprofen may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Pentamidine Pentamidine may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Etodolac Etodolac may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Mefenamic acid Mefenamic acid may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Acyclovir Acyclovir may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Naproxen Naproxen may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Sulfasalazine Sulfasalazine may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Phenylbutazone Phenylbutazone may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Meloxicam Meloxicam may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Carprofen Carprofen may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cefaclor Cefaclor may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Diflunisal Diflunisal may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Tacrolimus Tacrolimus may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Ceforanide Ceforanide may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Salicylic acid Salicylic acid may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Meclofenamic acid Meclofenamic acid may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Carboplatin Carboplatin may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Oxaprozin Oxaprozin may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Ketoprofen Ketoprofen may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Balsalazide Balsalazide may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Ibuprofen Ibuprofen may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cefditoren Cefditoren may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Atazanavir Atazanavir may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Colistimethate Colistimethate may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cefuroxime Cefuroxime may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cefapirin Cefapirin may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cefadroxil Cefadroxil may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cefprozil Cefprozil may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Ceftriaxone Ceftriaxone may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Olsalazine Olsalazine may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Lumiracoxib Lumiracoxib may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cefamandole Cefamandole may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cefazolin Cefazolin may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cefonicid Cefonicid may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cefoperazone Cefoperazone may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cefotetan Cefotetan may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cefoxitin Cefoxitin may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Ceftizoxime Ceftizoxime may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cefradine Cefradine may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Magnesium salicylate Magnesium salicylate may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Salsalate Salsalate may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Choline magnesium trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cefepime Cefepime may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cefacetrile Cefacetrile may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Ceftibuten Ceftibuten may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cefpodoxime Cefpodoxime may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Antrafenine Antrafenine may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Aminophenazone Aminophenazone may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Antipyrine Antipyrine may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Tiaprofenic acid Tiaprofenic acid may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Lopinavir Lopinavir may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Etoricoxib Etoricoxib may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Hydrolyzed Cephalothin Hydrolyzed Cephalothin may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cephalothin Group Cephalothin Group may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Oxyphenbutazone Oxyphenbutazone may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Latamoxef Latamoxef may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Nimesulide Nimesulide may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Benoxaprofen Benoxaprofen may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Metamizole Metamizole may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Zomepirac Zomepirac may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Ceftobiprole Ceftobiprole may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Cimicoxib Cimicoxib may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Ceftaroline fosamil Ceftaroline fosamil may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Lornoxicam Lornoxicam may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Aceclofenac Aceclofenac may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.

Target Protein

Sodium channel protein SCN1A

Referensi & Sumber

Artikel (PubMed)
  • PMID: 22579007
    McNally D, Shephard A, Field E: Randomised, double-blind, placebo-controlled study of a single dose of an amylmetacresol/2,4-dichlorobenzyl alcohol plus lidocaine lozenge or a hexylresorcinol lozenge for the treatment of acute sore throat due to upper respiratory tract infection. J Pharm Pharm Sci. 2012;15(2):281-94.
  • PMID: 28398972
    Tan TW, Chen BC, Tan HL, Chang CM: Effectiveness of amylmetacresol and 2,4-dichlorobenzyl alcohol throat lozenges in patients with acute sore throat due to upper respiratory tract infection: a systematic review protocol. JBI Database System Rev Implement Rep. 2017 Apr;15(4):862-872. doi: 10.11124/JBISRIR-2016-003034.
  • PMID: 15889535
    Oxford JS, Lambkin R, Gibb I, Balasingam S, Chan C, Catchpole A: A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV. Antivir Chem Chemother. 2005;16(2):129-34. doi: 10.1177/095632020501600205.
  • PMID: 28280379
    Morokutti-Kurz M, Graf C, Prieschl-Grassauer E: Amylmetacresol/2,4-dichlorobenzyl alcohol, hexylresorcinol, or carrageenan lozenges as active treatments for sore throat. Int J Gen Med. 2017 Feb 28;10:53-60. doi: 10.2147/IJGM.S120665. eCollection 2017.

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