Acetarsol

DB13268

small molecule approved withdrawn

Deskripsi

Acetarsol, with the molecular formula N-acetyl-4-hydroxy-m-arsanilic acid, is a pentavalent arsenical compound with antiprotozoal and antihelmintic properties.^L2622 It was first discovered in 1921 by Ernest Fourneau at the Pasteur Institute. It was developed by Neolab Inc, and approved by Health Canada as an antifungal on December 31, 1964. It has been canceled and withdrawn from the market since August 12, 1997.^L1113

Struktur Molekul 2D

Berat 275.0903

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) This pharmacokinetic property was not addressed.

Volume Distribusi This pharmacokinetic property was not addressed.

Klirens (Clearance) This pharmacokinetic property was not addressed.

Absorpsi

The absorption seems to be very minimal but there are reports of allergic reactions after vaginal administration of acetarsol.^A32839

Metabolisme

This pharmacokinetic property was not addressed.

Rute Eliminasi

The arsenic found in acetarsol is excreted mainly in the urine.T187 The level of arsenic after acetarsol administration almost reaches the toxic range in urine.^A32868

Interaksi Obat

1 Data

Tenofovir alafenamide

The serum concentration of Tenofovir alafenamide can be increased when it is combined with Acetarsol.

Referensi & Sumber

Artikel (PubMed)

PMID: 13199327
PECK BJ: Exfoliative dermatitis after acetarsol vaginal pessaries. Br Med J. 1954 Oct 9;2(4892):850-1.
PMID: 13374373
WHITE A: Acute systemic reaction to acetarsol. Br Med J. 1956 Dec 29;2(5008):1528-9.
PMID: 21577301
Lawrance IC: Novel topical therapies for distal colitis. World J Gastrointest Pharmacol Ther. 2010 Oct 6;1(5):87-93. doi: 10.4292/wjgpt.v1.i5.87.
PMID: 29457211
Kiely CJ, Clark A, Bhattacharyya J, Moran GW, Lee JC, Parkes M: Acetarsol Suppositories: Effective Treatment for Refractory Proctitis in a Cohort of Patients with Inflammatory Bowel Disease. Dig Dis Sci. 2018 Apr;63(4):1011-1015. doi: 10.1007/s10620-017-4890-6. Epub 2018 Feb 19.

Textbook

ISBN: 81-7648-125-4
Nath R. (2000). Health and disease role of micronutrients and trace elements. New Apcon.
ISBN: 0-398-05860-1
Morton W. and Schuman J. (1993). Toxicology of the eye (4th ed.). Charles C Thomas.

Link

Contoh Produk & Brand

Produk: 1 • International brands: 0

Produk

Neo Vagex

Tablet • - • Vaginal • Canada • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.

Peringatan Keamanan