Tiazofurine

DB13243

small molecule experimental

Deskripsi

Tiazofurine has potential clinical use in cancer treatment as it is a potential inhibitor of Inosine- 5’-monophosphate (IMP) dehydrogenase A174991.

Struktur Molekul 2D

Berat 260.267
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

39 Data
Darbepoetin alfa The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Tiazofurine.
Erythropoietin The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Tiazofurine.
Peginesatide The risk or severity of Thrombosis can be increased when Peginesatide is combined with Tiazofurine.
Methoxy polyethylene glycol-epoetin beta The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Tiazofurine.
Lidocaine The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Lidocaine.
Ropivacaine The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Ropivacaine.
Bupivacaine The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Bupivacaine.
Cinchocaine The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Cinchocaine.
Dyclonine The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Dyclonine.
Procaine The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Procaine.
Prilocaine The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Prilocaine.
Proparacaine The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Proparacaine.
Meloxicam The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Meloxicam.
Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Oxybuprocaine.
Cocaine The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Cocaine.
Mepivacaine The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Mepivacaine.
Levobupivacaine The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Levobupivacaine.
Diphenhydramine The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Diphenhydramine.
Benzocaine The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Benzocaine.
Chloroprocaine The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Chloroprocaine.
Phenol The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Phenol.
Tetrodotoxin The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Tetrodotoxin.
Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Benzyl alcohol.
Capsaicin The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Capsaicin.
Etidocaine The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Etidocaine.
Articaine The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Articaine.
Tetracaine The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Tetracaine.
Propoxycaine The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Propoxycaine.
Pramocaine The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Pramocaine.
Butamben The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Butamben.
Butacaine The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Butacaine.
Oxetacaine The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Oxetacaine.
Ethyl chloride The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Ethyl chloride.
Butanilicaine The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Butanilicaine.
Metabutethamine The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Metabutethamine.
Quinisocaine The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Quinisocaine.
Nelarabine The risk or severity of adverse effects can be increased when Nelarabine is combined with Tiazofurine.
Ambroxol The risk or severity of methemoglobinemia can be increased when Tiazofurine is combined with Ambroxol.
Etrasimod The risk or severity of immunosuppression can be increased when Tiazofurine is combined with Etrasimod.

Target Protein

Inosine-5'-monophosphate dehydrogenase 1 IMPDH1

Referensi & Sumber

Artikel (PubMed)
  • PMID: 3986813
    Melink TJ, Von Hoff DD, Kuhn JG, Hersh MR, Sternson LA, Patton TF, Siegler R, Boldt DH, Clark GM: Phase I evaluation and pharmacokinetics of tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide, NSC 286193). Cancer Res. 1985 Jun;45(6):2859-65.

Contoh Produk & Brand

Produk: 0 • International brands: 0
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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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