Peringatan Keamanan

Acute oral and dermal LD50 are 1500 mg/kg and >2000 mg/kg, respectively. The toxicity of perboric acid and its salt is thought to be local and reported to be slight irritation of the skin which can be explained by the release of hydrogen peroxide. Mutagenicity, fertility and carcinogenicity studies have not been performed but it is thought that the potential of perboric acid to produce mutagenic, fertility or carcinogenic effects is unlikely.^F67

Perboric acid

DB13235

small molecule approved

Deskripsi

Perboric acid is mainly found in its salt form of sodium perborate and it can be found as a monohydrate or tetrahydrate.^A33037 It is one of the peroxy acid salts with very wide functionalities in industrial settings.^F66 Perboric acid in the form of sodium perborate is approved by Health Canada since 2004 to be used as a disinfectant of medical instruments.^L1113 By the FDA, sodium perborate is approved as an ointment for the protection of poison ivy dermatitis.^L2764

Struktur Molekul 2D

Berat 59.82

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) As perboric acid and its sodium salt are rapidly degraded in the body, this pharmacokinetic property is studied in the terms of [DB09460] and [DB11091].

Volume Distribusi As perboric acid and its sodium salt are rapidly degraded in the body, this pharmacokinetic property is studied in the terms of [DB09460] and [DB11091].

Klirens (Clearance) As perboric acid and its sodium salt are rapidly degraded in the body, this pharmacokinetic property is studied in the terms of [DB09460] and [DB11091].[

Absorpsi

Dermal absorption is assumed to be very low due to the high hydrophilicity of perboric acid and its ionic nature.^F67

Metabolisme

If perboric acid or its sodium salt get in touch with body fluids, they will rapidly dissociate into hydrogen peroxide, carbonate and sodium ions which are naturally present in the body. The produced hydrogen peroxide is rapidly degraded in blood and tissues. As carbonate is part of the normal buffer system of the body it is unlikely to be absorbed in amounts that could disturb the normal balance of the body. The rest of the dissociation products are also not thought to produce any significant systemic modifications.^F67

Rute Eliminasi

As perboric acid and its sodium salt are rapidly degraded in the body, this pharmacokinetic property is studied in the terms of DB09460 and DB11091.

Interaksi Obat

0 Data

Tidak ada data.

Referensi & Sumber

Artikel (PubMed)

PMID: 19466262
Valera MC, Camargo CH, Carvalho CA, de Oliveira LD, Camargo SE, Rodrigues CM: Effectiveness of carbamide peroxide and sodium perborate in non-vital discolored teeth. J Appl Oral Sci. 2009 May-Jun;17(3):254-61.

Textbook

Troy B. and Beringer P. (2006). Remington: The Science and Practice of Pharmacy (21st ed.). Lippincott Williams & Wilkins.

Link

Attachment

Contoh Produk & Brand

Produk: 2 • International brands: 0

Produk

Amosan Oral Wound Cleanser

Powder, for solution • 1.2 g/1.7g • Oral • US • OTC
Amosan Wound Cleanser Cherry Flavour

Powder, for solution • 1.2 g/1.7g • Oral • US • OTC

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.