Peringatan Keamanan

The LDLo of calcium lactate pentahydrate following intravenous administration in mouse is 140 mg/kg MSDS.

Calcium lactate

DB13231

small molecule approved investigational vet_approved

Deskripsi

Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener L2741. Calcium lactate is also found in daily dietary supplements as a source of calcium. It is also available in various hydrate forms, where calcium lactate pentahydrate is the most common.

Struktur Molekul 2D

Berat 218.218
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) No pharmacokinetic data available.
Volume Distribusi The majority of calcium absorbed (99%) is stored in the skeleton and teeth for structural integrity [F59].
Klirens (Clearance) No pharmacokinetic data available.

Absorpsi

In order to be absorbed, calcium must be in its freely soluble form (Ca2+) or bound to a soluble organic molecule. Calcium absorption mainly occurs at the duodenum and proximal jejunum due to more acidic pH and the abundance of the calcium binding proteins F59. The mean calcium absorption is about 25% of calcium intake (range is 10 – 40%) in the small intestine, and is mediated by both passive diffusion and active transport F59.

Metabolisme

In hepatic gluconeogenesis, lactic acid is converted to glucose. Lactic acid may be further catabolyzed in the lactic acid cycle F59.

Rute Eliminasi

Following oral administration to a human volunteer, 20 to 30% of a dose of lactic acid of up to 3000 mg was excreted via the urine during a period of 14 hours F59.

Interaksi Obat

161 Data
Deferiprone The serum concentration of Deferiprone can be decreased when it is combined with Calcium lactate.
Dobutamine The therapeutic efficacy of Dobutamine can be decreased when used in combination with Calcium lactate.
Dolutegravir The serum concentration of Dolutegravir can be decreased when it is combined with Calcium lactate.
Eltrombopag The serum concentration of Eltrombopag can be decreased when it is combined with Calcium lactate.
Estramustine Calcium lactate can cause a decrease in the absorption of Estramustine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium acetate The risk or severity of adverse effects can be increased when Calcium lactate is combined with Calcium acetate.
Digoxin Calcium lactate may increase the arrhythmogenic and cardiotoxic activities of Digoxin.
Acetyldigitoxin Calcium lactate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin.
Deslanoside Calcium lactate may increase the arrhythmogenic and cardiotoxic activities of Deslanoside.
Ouabain Calcium lactate may increase the arrhythmogenic and cardiotoxic activities of Ouabain.
Digitoxin Calcium lactate may increase the arrhythmogenic and cardiotoxic activities of Digitoxin.
Oleandrin Calcium lactate may increase the arrhythmogenic and cardiotoxic activities of Oleandrin.
Cymarin Calcium lactate may increase the arrhythmogenic and cardiotoxic activities of Cymarin.
Proscillaridin Calcium lactate may increase the arrhythmogenic and cardiotoxic activities of Proscillaridin.
Metildigoxin Calcium lactate may increase the arrhythmogenic and cardiotoxic activities of Metildigoxin.
Lanatoside C Calcium lactate may increase the arrhythmogenic and cardiotoxic activities of Lanatoside C.
Gitoformate Calcium lactate may increase the arrhythmogenic and cardiotoxic activities of Gitoformate.
Acetyldigoxin Calcium lactate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigoxin.
Peruvoside Calcium lactate may increase the arrhythmogenic and cardiotoxic activities of Peruvoside.
Grepafloxacin Calcium lactate can cause a decrease in the absorption of Grepafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Enoxacin Calcium lactate can cause a decrease in the absorption of Enoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pefloxacin Calcium lactate can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ciprofloxacin Calcium lactate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Trovafloxacin Calcium lactate can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nalidixic acid Calcium lactate can cause a decrease in the absorption of Nalidixic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rosoxacin Calcium lactate can cause a decrease in the absorption of Rosoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cinoxacin Calcium lactate can cause a decrease in the absorption of Cinoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lomefloxacin Calcium lactate can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gatifloxacin Calcium lactate can cause a decrease in the absorption of Gatifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Norfloxacin Calcium lactate can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gemifloxacin Calcium lactate can cause a decrease in the absorption of Gemifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ofloxacin Calcium lactate can cause a decrease in the absorption of Ofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sparfloxacin Calcium lactate can cause a decrease in the absorption of Sparfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Temafloxacin Calcium lactate can cause a decrease in the absorption of Temafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Fleroxacin Calcium lactate can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Technetium Tc-99m ciprofloxacin Calcium lactate can cause a decrease in the absorption of Technetium Tc-99m ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Garenoxacin Calcium lactate can cause a decrease in the absorption of Garenoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nemonoxacin Calcium lactate can cause a decrease in the absorption of Nemonoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Flumequine Calcium lactate can cause a decrease in the absorption of Flumequine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Enrofloxacin Calcium lactate can cause a decrease in the absorption of Enrofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Orbifloxacin Calcium lactate can cause a decrease in the absorption of Orbifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sarafloxacin Calcium lactate can cause a decrease in the absorption of Sarafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Difloxacin Calcium lactate can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pazufloxacin Calcium lactate can cause a decrease in the absorption of Pazufloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Prulifloxacin Calcium lactate can cause a decrease in the absorption of Prulifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Delafloxacin Calcium lactate can cause a decrease in the absorption of Delafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sitafloxacin Calcium lactate can cause a decrease in the absorption of Sitafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Oxolinic acid Calcium lactate can cause a decrease in the absorption of Oxolinic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rufloxacin Calcium lactate can cause a decrease in the absorption of Rufloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pipemidic acid Calcium lactate can cause a decrease in the absorption of Pipemidic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Strontium ranelate The serum concentration of Strontium ranelate can be decreased when it is combined with Calcium lactate.
Doxycycline The serum concentration of Doxycycline can be decreased when it is combined with Calcium lactate.
Lymecycline The serum concentration of Lymecycline can be decreased when it is combined with Calcium lactate.
Clomocycline The serum concentration of Clomocycline can be decreased when it is combined with Calcium lactate.
Oxytetracycline The serum concentration of Oxytetracycline can be decreased when it is combined with Calcium lactate.
Demeclocycline The serum concentration of Demeclocycline can be decreased when it is combined with Calcium lactate.
Tetracycline The serum concentration of Tetracycline can be decreased when it is combined with Calcium lactate.
Metacycline The serum concentration of Metacycline can be decreased when it is combined with Calcium lactate.
Minocycline The serum concentration of Minocycline can be decreased when it is combined with Calcium lactate.
Sarecycline The serum concentration of Sarecycline can be decreased when it is combined with Calcium lactate.
Omadacycline The serum concentration of Omadacycline can be decreased when it is combined with Calcium lactate.
Penimepicycline The serum concentration of Penimepicycline can be decreased when it is combined with Calcium lactate.
Methyclothiazide Methyclothiazide may decrease the excretion rate of Calcium lactate which could result in a higher serum level.
Chlorthalidone Chlorthalidone may decrease the excretion rate of Calcium lactate which could result in a higher serum level.
Bendroflumethiazide Bendroflumethiazide may decrease the excretion rate of Calcium lactate which could result in a higher serum level.
Metolazone Metolazone may decrease the excretion rate of Calcium lactate which could result in a higher serum level.
Benzthiazide Benzthiazide may decrease the excretion rate of Calcium lactate which could result in a higher serum level.
Hydroflumethiazide Hydroflumethiazide may decrease the excretion rate of Calcium lactate which could result in a higher serum level.
Indapamide Indapamide may decrease the excretion rate of Calcium lactate which could result in a higher serum level.
Chlorothiazide Chlorothiazide may decrease the excretion rate of Calcium lactate which could result in a higher serum level.
Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Calcium lactate which could result in a higher serum level.
Trichlormethiazide Trichlormethiazide may decrease the excretion rate of Calcium lactate which could result in a higher serum level.
Polythiazide Polythiazide may decrease the excretion rate of Calcium lactate which could result in a higher serum level.
Quinethazone Quinethazone may decrease the excretion rate of Calcium lactate which could result in a higher serum level.
Cyclopenthiazide Cyclopenthiazide may decrease the excretion rate of Calcium lactate which could result in a higher serum level.
Epitizide Epitizide may decrease the excretion rate of Calcium lactate which could result in a higher serum level.
Triethylenetetramine Calcium lactate can cause a decrease in the absorption of Triethylenetetramine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcitriol The risk or severity of adverse effects can be increased when Calcitriol is combined with Calcium lactate.
Calcifediol The risk or severity of adverse effects can be increased when Calcifediol is combined with Calcium lactate.
Ergocalciferol The risk or severity of adverse effects can be increased when Ergocalciferol is combined with Calcium lactate.
Paricalcitol The risk or severity of adverse effects can be increased when Paricalcitol is combined with Calcium lactate.
Dihydrotachysterol The risk or severity of adverse effects can be increased when Dihydrotachysterol is combined with Calcium lactate.
Alfacalcidol The risk or severity of adverse effects can be increased when Alfacalcidol is combined with Calcium lactate.
Calcipotriol The risk or severity of adverse effects can be increased when Calcipotriol is combined with Calcium lactate.
Seocalcitol The risk or severity of adverse effects can be increased when Seocalcitol is combined with Calcium lactate.
Inecalcitol The risk or severity of adverse effects can be increased when Inecalcitol is combined with Calcium lactate.
Becocalcidiol The risk or severity of adverse effects can be increased when Becocalcidiol is combined with Calcium lactate.
Eldecalcitol The risk or severity of adverse effects can be increased when Eldecalcitol is combined with Calcium lactate.
1alpha,24S-Dihydroxyvitamin D2 The risk or severity of adverse effects can be increased when 1alpha,24S-Dihydroxyvitamin D2 is combined with Calcium lactate.
Elocalcitol The risk or severity of adverse effects can be increased when Elocalcitol is combined with Calcium lactate.
Maxacalcitol The risk or severity of adverse effects can be increased when Maxacalcitol is combined with Calcium lactate.
Doxercalciferol The risk or severity of adverse effects can be increased when Doxercalciferol is combined with Calcium lactate.
1alpha-Hydroxyvitamin D5 The risk or severity of adverse effects can be increased when 1alpha-Hydroxyvitamin D5 is combined with Calcium lactate.
Tacalcitol The risk or severity of adverse effects can be increased when Tacalcitol is combined with Calcium lactate.
Previtamin D(3) The risk or severity of adverse effects can be increased when Previtamin D(3) is combined with Calcium lactate.
Thyrotropin alfa The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Calcium lactate.
Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Calcium lactate.
Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Calcium lactate.
Liotrix The therapeutic efficacy of Liotrix can be decreased when used in combination with Calcium lactate.
Tiratricol The therapeutic efficacy of Tiratricol can be decreased when used in combination with Calcium lactate.

Referensi & Sumber

Contoh Produk & Brand

Produk: 31 • International brands: 0
Produk
  • Cal M Tab
    Tablet • - • Oral • Canada • OTC • Approved
  • Cal-mag Tablet
    Tablet • - • Oral • Canada • Approved
  • Calcimax Tab 324mg
    Tablet • 324 mg / tab • Oral • Canada • OTC • Approved
  • Calcium Ctr Srt
    Tablet, extended release • - • Oral • Canada • OTC • Approved
  • Calcium Lactate 650mg
    Tablet • 120 mg • Oral • Canada • OTC • Approved
  • Calcium Lactate Caps
    Capsule • 100 mg / cap • Oral • Canada • OTC • Approved
  • Calcium Lactate Et Magnesium Sulfate
    Tablet • - • Oral • Canada • OTC • Approved
  • Calcium Lactate Powder
    Powder • - • Oral • Canada • Approved
Menampilkan 8 dari 31 produk.

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