Medifoxamine

DB13219

small molecule approved

Deskripsi

Medifoxamine was marketed as an atypical antidepressant, with anxiolyitc properties in France, Spain, and Morrocco in the 1990s but was later withdrawn from the market due to it causing cases of hepatotoxicity L5461, A174976.

Struktur Molekul 2D

Berat 257.333
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

676 Data
Buprenorphine Medifoxamine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Medifoxamine.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Medifoxamine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Medifoxamine.
Hydrocodone Medifoxamine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Medifoxamine.
Magnesium sulfate The therapeutic efficacy of Medifoxamine can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Medifoxamine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Medifoxamine may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Medifoxamine.
Mirtazapine Medifoxamine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Medifoxamine.
Orphenadrine Medifoxamine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Medifoxamine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Medifoxamine.
Pramipexole Medifoxamine may increase the sedative activities of Pramipexole.
Ropinirole Medifoxamine may increase the sedative activities of Ropinirole.
Rotigotine Medifoxamine may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Medifoxamine.
Sodium oxybate Medifoxamine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Medifoxamine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Medifoxamine.
Thalidomide Medifoxamine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Medifoxamine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Medifoxamine.
Dicoumarol The risk or severity of adverse effects can be increased when Medifoxamine is combined with Dicoumarol.
Phenindione The risk or severity of adverse effects can be increased when Medifoxamine is combined with Phenindione.
Warfarin The risk or severity of adverse effects can be increased when Medifoxamine is combined with Warfarin.
Phenprocoumon The risk or severity of adverse effects can be increased when Medifoxamine is combined with Phenprocoumon.
Acenocoumarol The risk or severity of adverse effects can be increased when Medifoxamine is combined with Acenocoumarol.
4-hydroxycoumarin The risk or severity of adverse effects can be increased when Medifoxamine is combined with 4-hydroxycoumarin.
Coumarin The risk or severity of adverse effects can be increased when Medifoxamine is combined with Coumarin.
(R)-warfarin The risk or severity of adverse effects can be increased when Medifoxamine is combined with (R)-warfarin.
Ethyl biscoumacetate The risk or severity of adverse effects can be increased when Medifoxamine is combined with Ethyl biscoumacetate.
Fluindione The risk or severity of adverse effects can be increased when Medifoxamine is combined with Fluindione.
Clorindione The risk or severity of adverse effects can be increased when Medifoxamine is combined with Clorindione.
Diphenadione The risk or severity of adverse effects can be increased when Medifoxamine is combined with Diphenadione.
Tioclomarol The risk or severity of adverse effects can be increased when Medifoxamine is combined with Tioclomarol.
(S)-Warfarin The risk or severity of adverse effects can be increased when Medifoxamine is combined with (S)-Warfarin.
Ethanol Medifoxamine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Medifoxamine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Medifoxamine.
Fluvoxamine The risk or severity of adverse effects can be increased when Medifoxamine is combined with Fluvoxamine.
Citalopram The risk or severity of adverse effects can be increased when Medifoxamine is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Medifoxamine is combined with Duloxetine.
Trazodone The risk or severity of adverse effects can be increased when Medifoxamine is combined with Trazodone.
Paroxetine The risk or severity of adverse effects can be increased when Medifoxamine is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Medifoxamine is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Medifoxamine is combined with Sibutramine.
Nefazodone The risk or severity of adverse effects can be increased when Medifoxamine is combined with Nefazodone.
Escitalopram The risk or severity of adverse effects can be increased when Medifoxamine is combined with Escitalopram.
Zimelidine The risk or severity of adverse effects can be increased when Medifoxamine is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Medifoxamine is combined with Dapoxetine.
Milnacipran The risk or severity of adverse effects can be increased when Medifoxamine is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Medifoxamine is combined with Desvenlafaxine.
Seproxetine The risk or severity of adverse effects can be increased when Medifoxamine is combined with Seproxetine.
Indalpine The risk or severity of adverse effects can be increased when Medifoxamine is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Medifoxamine is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Medifoxamine is combined with Alaproclate.
Zopiclone The risk or severity of adverse effects can be increased when Medifoxamine is combined with Zopiclone.
Botulinum toxin type B The risk or severity of CNS depression can be increased when Botulinum toxin type B is combined with Medifoxamine.
Botulinum toxin type A The risk or severity of CNS depression can be increased when Botulinum toxin type A is combined with Medifoxamine.
Tryptophan The risk or severity of CNS depression can be increased when Tryptophan is combined with Medifoxamine.
Baclofen Baclofen may increase the central nervous system depressant (CNS depressant) activities of Medifoxamine.
Lorazepam The risk or severity of CNS depression can be increased when Lorazepam is combined with Medifoxamine.
Ethchlorvynol The risk or severity of CNS depression can be increased when Ethchlorvynol is combined with Medifoxamine.
Succinylcholine The risk or severity of CNS depression can be increased when Succinylcholine is combined with Medifoxamine.
Reserpine The risk or severity of CNS depression can be increased when Reserpine is combined with Medifoxamine.
Eletriptan The risk or severity of CNS depression can be increased when Eletriptan is combined with Medifoxamine.
Enflurane The risk or severity of CNS depression can be increased when Enflurane is combined with Medifoxamine.
Temazepam The risk or severity of CNS depression can be increased when Temazepam is combined with Medifoxamine.
Reboxetine The risk or severity of CNS depression can be increased when Reboxetine is combined with Medifoxamine.
Butabarbital The risk or severity of CNS depression can be increased when Butabarbital is combined with Medifoxamine.
Butalbital The risk or severity of CNS depression can be increased when Butalbital is combined with Medifoxamine.
Methysergide The risk or severity of CNS depression can be increased when Methysergide is combined with Medifoxamine.
Cabergoline The risk or severity of CNS depression can be increased when Cabergoline is combined with Medifoxamine.
Phenytoin The risk or severity of CNS depression can be increased when Phenytoin is combined with Medifoxamine.
Topiramate The risk or severity of CNS depression can be increased when Topiramate is combined with Medifoxamine.
Clemastine The risk or severity of CNS depression can be increased when Clemastine is combined with Medifoxamine.
Venlafaxine The risk or severity of CNS depression can be increased when Venlafaxine is combined with Medifoxamine.
Etomidate The risk or severity of CNS depression can be increased when Etomidate is combined with Medifoxamine.
Morphine The risk or severity of CNS depression can be increased when Morphine is combined with Medifoxamine.
Talbutal The risk or severity of CNS depression can be increased when Talbutal is combined with Medifoxamine.
Pentobarbital The risk or severity of CNS depression can be increased when Pentobarbital is combined with Medifoxamine.
Valproic acid The risk or severity of CNS depression can be increased when Valproic acid is combined with Medifoxamine.
Zolmitriptan The risk or severity of CNS depression can be increased when Zolmitriptan is combined with Medifoxamine.
Codeine The risk or severity of CNS depression can be increased when Codeine is combined with Medifoxamine.
Dihydroergotamine The risk or severity of CNS depression can be increased when Dihydroergotamine is combined with Medifoxamine.
Amitriptyline The risk or severity of CNS depression can be increased when Amitriptyline is combined with Medifoxamine.
Tolcapone The risk or severity of CNS depression can be increased when Tolcapone is combined with Medifoxamine.
Hydromorphone The risk or severity of CNS depression can be increased when Hydromorphone is combined with Medifoxamine.
Olanzapine The risk or severity of CNS depression can be increased when Olanzapine is combined with Medifoxamine.
Cetirizine The risk or severity of CNS depression can be increased when Cetirizine is combined with Medifoxamine.
Protriptyline The risk or severity of CNS depression can be increased when Protriptyline is combined with Medifoxamine.
Trimethadione The risk or severity of CNS depression can be increased when Trimethadione is combined with Medifoxamine.
Clobazam The risk or severity of sedation, somnolence, and CNS depression can be increased when Clobazam is combined with Medifoxamine.
Chlorzoxazone The risk or severity of CNS depression can be increased when Chlorzoxazone is combined with Medifoxamine.
Clozapine The risk or severity of CNS depression can be increased when Clozapine is combined with Medifoxamine.
Meprobamate The risk or severity of CNS depression can be increased when Meprobamate is combined with Medifoxamine.
Thiethylperazine The risk or severity of CNS depression can be increased when Thiethylperazine is combined with Medifoxamine.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 8668756
    Mitchell PB: Novel French antidepressants not available in the United States. Psychopharmacol Bull. 1995;31(3):509-19.

Contoh Produk & Brand

Produk: 0 • International brands: 0
Belum ada data produk/brand untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field produk/brand.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul