Peringatan Keamanan

Troleandomycin inhibits clearance of theophylline and can increase the likelyhood of toxicity in patients recieving theophylline therapy A19571.

Troleandomycin

DB13179

small molecule approved

Deskripsi

A macrolide antibiotic that is similar to erythromycin.

Struktur Molekul 2D

Berat 813.9684
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

902 Data
Eliglustat The metabolism of Eliglustat can be decreased when combined with Troleandomycin.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Troleandomycin.
Alfentanil The serum concentration of Alfentanil can be increased when it is combined with Troleandomycin.
Buspirone The metabolism of Buspirone can be decreased when combined with Troleandomycin.
Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Troleandomycin.
Cisapride The serum concentration of Cisapride can be increased when it is combined with Troleandomycin.
Disopyramide Troleandomycin may increase the QTc-prolonging activities of Disopyramide.
Estazolam The serum concentration of Estazolam can be increased when it is combined with Troleandomycin.
Quinine The serum concentration of Quinine can be increased when it is combined with Troleandomycin.
Quinidine The metabolism of Quinidine can be decreased when combined with Troleandomycin.
Repaglinide The serum concentration of Repaglinide can be increased when it is combined with Troleandomycin.
Rilpivirine The serum concentration of Rilpivirine can be increased when it is combined with Troleandomycin.
Terfenadine The serum concentration of Terfenadine can be increased when it is combined with Troleandomycin.
Triazolam The serum concentration of Triazolam can be increased when it is combined with Troleandomycin.
Cilostazol The metabolism of Cilostazol can be decreased when combined with Troleandomycin.
Colchicine The metabolism of Colchicine can be decreased when combined with Troleandomycin.
Fentanyl The metabolism of Fentanyl can be decreased when combined with Troleandomycin.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Troleandomycin.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Troleandomycin.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Troleandomycin.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Troleandomycin.
Alprazolam The serum concentration of Alprazolam can be increased when it is combined with Troleandomycin.
R,S-Warfarin alcohol The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Troleandomycin.
S,R-Warfarin alcohol The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Troleandomycin.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Troleandomycin.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Troleandomycin.
Telaprevir The serum concentration of Telaprevir can be increased when it is combined with Troleandomycin.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Troleandomycin.
Vintafolide The serum concentration of Vintafolide can be increased when it is combined with Troleandomycin.
Vincamine The serum concentration of Vincamine can be increased when it is combined with Troleandomycin.
Acetyldigitoxin The serum concentration of Acetyldigitoxin can be increased when it is combined with Troleandomycin.
Deslanoside The serum concentration of Deslanoside can be increased when it is combined with Troleandomycin.
Ouabain The serum concentration of Ouabain can be increased when it is combined with Troleandomycin.
Oleandrin The serum concentration of Oleandrin can be increased when it is combined with Troleandomycin.
Cymarin The serum concentration of Cymarin can be increased when it is combined with Troleandomycin.
Proscillaridin The serum concentration of Proscillaridin can be increased when it is combined with Troleandomycin.
Lanatoside C The serum concentration of Lanatoside C can be increased when it is combined with Troleandomycin.
Gitoformate The serum concentration of Gitoformate can be increased when it is combined with Troleandomycin.
Peruvoside The serum concentration of Peruvoside can be increased when it is combined with Troleandomycin.
Metildigoxin The serum concentration of Metildigoxin can be increased when it is combined with Troleandomycin.
Acetyldigoxin The serum concentration of Acetyldigoxin can be increased when it is combined with Troleandomycin.
Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Troleandomycin.
Dicoumarol The serum concentration of Dicoumarol can be increased when it is combined with Troleandomycin.
Phenindione The serum concentration of Phenindione can be increased when it is combined with Troleandomycin.
Coumarin The serum concentration of Coumarin can be increased when it is combined with Troleandomycin.
Tioclomarol The serum concentration of Tioclomarol can be increased when it is combined with Troleandomycin.
4-hydroxycoumarin The serum concentration of 4-hydroxycoumarin can be increased when it is combined with Troleandomycin.
Fluindione The serum concentration of Fluindione can be increased when it is combined with Troleandomycin.
Clorindione The serum concentration of Clorindione can be increased when it is combined with Troleandomycin.
Oxtriphylline The metabolism of Oxtriphylline can be decreased when combined with Troleandomycin.
Doxofylline The metabolism of Doxofylline can be decreased when combined with Troleandomycin.
Bamifylline The metabolism of Bamifylline can be decreased when combined with Troleandomycin.
Acefylline The metabolism of Acefylline can be decreased when combined with Troleandomycin.
Bufylline The metabolism of Bufylline can be decreased when combined with Troleandomycin.
Fenethylline The metabolism of Fenethylline can be decreased when combined with Troleandomycin.
Proxyphylline The metabolism of Proxyphylline can be decreased when combined with Troleandomycin.
Bromotheophylline The metabolism of Bromotheophylline can be decreased when combined with Troleandomycin.
Pentoxifylline The metabolism of Pentoxifylline can be decreased when combined with Troleandomycin.
8-azaguanine The metabolism of 8-azaguanine can be decreased when combined with Troleandomycin.
7,9-Dimethylguanine The metabolism of 7,9-Dimethylguanine can be decreased when combined with Troleandomycin.
Xanthine The metabolism of Xanthine can be decreased when combined with Troleandomycin.
7-Deazaguanine The metabolism of 7-Deazaguanine can be decreased when combined with Troleandomycin.
Guanine The metabolism of Guanine can be decreased when combined with Troleandomycin.
9-Methylguanine The metabolism of 9-Methylguanine can be decreased when combined with Troleandomycin.
Peldesine The metabolism of Peldesine can be decreased when combined with Troleandomycin.
Hypoxanthine The metabolism of Hypoxanthine can be decreased when combined with Troleandomycin.
9-Deazaguanine The metabolism of 9-Deazaguanine can be decreased when combined with Troleandomycin.
Valomaciclovir The metabolism of Valomaciclovir can be decreased when combined with Troleandomycin.
3-isobutyl-1-methyl-7H-xanthine The metabolism of 3-isobutyl-1-methyl-7H-xanthine can be decreased when combined with Troleandomycin.
Uric acid The metabolism of Uric acid can be decreased when combined with Troleandomycin.
Lisofylline The metabolism of Lisofylline can be decreased when combined with Troleandomycin.
Lobucavir The metabolism of Lobucavir can be decreased when combined with Troleandomycin.
Cafedrine The metabolism of Cafedrine can be decreased when combined with Troleandomycin.
Theodrenaline The metabolism of Theodrenaline can be decreased when combined with Troleandomycin.
Etamiphylline The metabolism of Etamiphylline can be decreased when combined with Troleandomycin.
Pentifylline The metabolism of Pentifylline can be decreased when combined with Troleandomycin.
Furafylline The metabolism of Furafylline can be decreased when combined with Troleandomycin.
Theobromine The metabolism of Theobromine can be decreased when combined with Troleandomycin.
Propentofylline The metabolism of Propentofylline can be decreased when combined with Troleandomycin.
8-chlorotheophylline The metabolism of 8-chlorotheophylline can be decreased when combined with Troleandomycin.
Mercaptopurine The metabolism of Mercaptopurine can be decreased when combined with Troleandomycin.
PCS-499 The metabolism of PCS-499 can be decreased when combined with Troleandomycin.
Caffeine The metabolism of Caffeine can be decreased when combined with Troleandomycin.
BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Troleandomycin.
Typhoid vaccine The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Troleandomycin.
Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Troleandomycin.
Pitolisant The serum concentration of Troleandomycin can be decreased when it is combined with Pitolisant.
Metreleptin The metabolism of Troleandomycin can be increased when combined with Metreleptin.
Pentamidine The metabolism of Pentamidine can be decreased when combined with Troleandomycin.
Metronidazole The metabolism of Metronidazole can be decreased when combined with Troleandomycin.
Dutasteride The metabolism of Dutasteride can be decreased when combined with Troleandomycin.
Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Troleandomycin.
Fluticasone The metabolism of Fluticasone can be decreased when combined with Troleandomycin.
Apomorphine The metabolism of Apomorphine can be decreased when combined with Troleandomycin.
Tegafur The metabolism of Tegafur can be decreased when combined with Troleandomycin.
Prasterone sulfate The metabolism of Prasterone sulfate can be decreased when combined with Troleandomycin.
Prucalopride The metabolism of Prucalopride can be decreased when combined with Troleandomycin.
Digoxin The serum concentration of Digoxin can be increased when it is combined with Troleandomycin.
Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Troleandomycin.
Triamcinolone Troleandomycin may decrease the excretion rate of Triamcinolone which could result in a higher serum level.

Target Protein

50S ribosomal protein L32 rpmF
50S ribosomal protein L4 rplD
Nuclear receptor subfamily 1 group I member 2 NR1I2

Referensi & Sumber

Artikel (PubMed)
  • PMID: 300083
    Weinberger M, Hudgel D, Spector S, Chidsey C: Inhibition of theophylline clearance by troleandomycin. J Allergy Clin Immunol. 1977 Mar;59(3):228-31.
Textbook
  • ISBN: 978-0-7020-3471-8
    5. (2012). In Rang and Dale's Pharmacology (7th ed., pp. 614, 631-632). Edinburgh: Elsevier/Churchill Livingstone.

Contoh Produk & Brand

Produk: 0 • International brands: 2
International Brands
  • Tao
  • Triocetin

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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