Oral LD50 of >5000mg/kg in mice MSDS.
Rhein is an anthraquinone metabolite of rheinanthrone and senna glycoside is present in many medicinal plants including Rheum palmatum, Cassia tora, Polygonum multiflorum, and Aloe barbadensis A19247. It is known to have hepatoprotective, nephroprotective, anti-cancer, anti-inflammatory, and several other protective effects.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Brexpiprazole | The metabolism of Brexpiprazole can be decreased when combined with Rhein. |
| Eliglustat | The metabolism of Eliglustat can be decreased when combined with Rhein. |
| Zolmitriptan | The metabolism of Zolmitriptan can be decreased when combined with Rhein. |
| Atomoxetine | The metabolism of Atomoxetine can be decreased when combined with Rhein. |
| Phenytoin | The metabolism of Phenytoin can be decreased when combined with Rhein. |
| Nevirapine | The metabolism of Nevirapine can be decreased when combined with Rhein. |
| Amphetamine | The metabolism of Amphetamine can be decreased when combined with Rhein. |
| Cevimeline | The metabolism of Cevimeline can be decreased when combined with Rhein. |
| Esmolol | The metabolism of Esmolol can be decreased when combined with Rhein. |
| Sildenafil | The metabolism of Sildenafil can be decreased when combined with Rhein. |
| Ticlopidine | The metabolism of Ticlopidine can be decreased when combined with Rhein. |
| Citalopram | The metabolism of Citalopram can be decreased when combined with Rhein. |
| Eletriptan | The metabolism of Eletriptan can be decreased when combined with Rhein. |
| Ranolazine | The metabolism of Ranolazine can be decreased when combined with Rhein. |
| Benzatropine | The metabolism of Benzatropine can be decreased when combined with Rhein. |
| Metoprolol | The metabolism of Metoprolol can be decreased when combined with Rhein. |
| Venlafaxine | The metabolism of Venlafaxine can be decreased when combined with Rhein. |
| Bupivacaine | The metabolism of Bupivacaine can be decreased when combined with Rhein. |
| Gefitinib | The metabolism of Gefitinib can be decreased when combined with Rhein. |
| Codeine | The metabolism of Codeine can be decreased when combined with Rhein. |
| Methadone | The metabolism of Methadone can be decreased when combined with Rhein. |
| Atenolol | The metabolism of Atenolol can be decreased when combined with Rhein. |
| Terfenadine | The metabolism of Terfenadine can be decreased when combined with Rhein. |
| Diltiazem | The metabolism of Diltiazem can be decreased when combined with Rhein. |
| Palonosetron | The metabolism of Palonosetron can be decreased when combined with Rhein. |
| Progesterone | The metabolism of Progesterone can be decreased when combined with Rhein. |
| Remoxipride | The metabolism of Remoxipride can be decreased when combined with Rhein. |
| Prochlorperazine | The metabolism of Prochlorperazine can be decreased when combined with Rhein. |
| Celecoxib | The metabolism of Celecoxib can be decreased when combined with Rhein. |
| Sotalol | The metabolism of Sotalol can be decreased when combined with Rhein. |
| Buspirone | The metabolism of Buspirone can be decreased when combined with Rhein. |
| Darifenacin | The metabolism of Darifenacin can be decreased when combined with Rhein. |
| Oxycodone | The metabolism of Oxycodone can be decreased when combined with Rhein. |
| Ritonavir | The metabolism of Ritonavir can be decreased when combined with Rhein. |
| Dextromethorphan | The metabolism of Dextromethorphan can be decreased when combined with Rhein. |
| Amoxapine | The metabolism of Amoxapine can be decreased when combined with Rhein. |
| Lisuride | The metabolism of Lisuride can be decreased when combined with Rhein. |
| Doxazosin | The metabolism of Doxazosin can be decreased when combined with Rhein. |
| Piperazine | The metabolism of Piperazine can be decreased when combined with Rhein. |
| Chloroquine | The metabolism of Chloroquine can be decreased when combined with Rhein. |
| Astemizole | The metabolism of Astemizole can be decreased when combined with Rhein. |
| Simvastatin | The metabolism of Simvastatin can be decreased when combined with Rhein. |
| Dextropropoxyphene | The metabolism of Dextropropoxyphene can be decreased when combined with Rhein. |
| Trazodone | The metabolism of Trazodone can be decreased when combined with Rhein. |
| Galantamine | The metabolism of Galantamine can be decreased when combined with Rhein. |
| Tamoxifen | The metabolism of Tamoxifen can be decreased when combined with Rhein. |
| Thioridazine | The metabolism of Thioridazine can be decreased when combined with Rhein. |
| Nicergoline | The metabolism of Nicergoline can be decreased when combined with Rhein. |
| Amprenavir | The metabolism of Amprenavir can be decreased when combined with Rhein. |
| Delavirdine | The metabolism of Delavirdine can be decreased when combined with Rhein. |
| Tamsulosin | The metabolism of Tamsulosin can be decreased when combined with Rhein. |
| Trimipramine | The metabolism of Trimipramine can be decreased when combined with Rhein. |
| Nateglinide | The metabolism of Nateglinide can be decreased when combined with Rhein. |
| Risperidone | The metabolism of Risperidone can be decreased when combined with Rhein. |
| Meclizine | The metabolism of Meclizine can be decreased when combined with Rhein. |
| Pentamidine | The metabolism of Pentamidine can be decreased when combined with Rhein. |
| Dolasetron | The metabolism of Dolasetron can be decreased when combined with Rhein. |
| Minaprine | The metabolism of Minaprine can be decreased when combined with Rhein. |
| Donepezil | The metabolism of Donepezil can be decreased when combined with Rhein. |
| Alprenolol | The metabolism of Alprenolol can be decreased when combined with Rhein. |
| Ondansetron | The metabolism of Ondansetron can be decreased when combined with Rhein. |
| Phenformin | The metabolism of Phenformin can be decreased when combined with Rhein. |
| Almotriptan | The metabolism of Almotriptan can be decreased when combined with Rhein. |
| Buprenorphine | The metabolism of Buprenorphine can be decreased when combined with Rhein. |
| Tipranavir | The metabolism of Tipranavir can be decreased when combined with Rhein. |
| Mesoridazine | The metabolism of Mesoridazine can be decreased when combined with Rhein. |
| Hydrocodone | The metabolism of Hydrocodone can be decreased when combined with Rhein. |
| Pindolol | The metabolism of Pindolol can be decreased when combined with Rhein. |
| Azelastine | The metabolism of Azelastine can be decreased when combined with Rhein. |
| Formoterol | The metabolism of Formoterol can be decreased when combined with Rhein. |
| Methoxyflurane | The metabolism of Methoxyflurane can be decreased when combined with Rhein. |
| Procainamide | The metabolism of Procainamide can be decreased when combined with Rhein. |
| Tolterodine | The metabolism of Tolterodine can be decreased when combined with Rhein. |
| Promethazine | The metabolism of Promethazine can be decreased when combined with Rhein. |
| Mequitazine | The metabolism of Mequitazine can be decreased when combined with Rhein. |
| Perhexiline | The metabolism of Perhexiline can be decreased when combined with Rhein. |
| Diphenhydramine | The metabolism of Diphenhydramine can be decreased when combined with Rhein. |
| Tegaserod | The metabolism of Tegaserod can be decreased when combined with Rhein. |
| Fluvastatin | The metabolism of Fluvastatin can be decreased when combined with Rhein. |
| Sertraline | The metabolism of Sertraline can be decreased when combined with Rhein. |
| Chlorpheniramine | The metabolism of Chlorpheniramine can be decreased when combined with Rhein. |
| Nefazodone | The metabolism of Nefazodone can be decreased when combined with Rhein. |
| Moclobemide | The metabolism of Moclobemide can be decreased when combined with Rhein. |
| Escitalopram | The metabolism of Escitalopram can be decreased when combined with Rhein. |
| Idarubicin | The metabolism of Idarubicin can be decreased when combined with Rhein. |
| Oxymorphone | The metabolism of Oxymorphone can be decreased when combined with Rhein. |
| Acebutolol | The metabolism of Acebutolol can be decreased when combined with Rhein. |
| Flecainide | The metabolism of Flecainide can be decreased when combined with Rhein. |
| Nadolol | The metabolism of Nadolol can be decreased when combined with Rhein. |
| Quetiapine | The metabolism of Quetiapine can be decreased when combined with Rhein. |
| Encainide | The metabolism of Encainide can be decreased when combined with Rhein. |
| Metoclopramide | The metabolism of Metoclopramide can be decreased when combined with Rhein. |
| Bepridil | The metabolism of Bepridil can be decreased when combined with Rhein. |
| Lisdexamfetamine | The serum concentration of dextroamphetamine, an active metabolite of Lisdexamfetamine, can be increased when used in combination with Rhein. |
| Paliperidone | The metabolism of Paliperidone can be decreased when combined with Rhein. |
| Arformoterol | The metabolism of Arformoterol can be decreased when combined with Rhein. |
| Bevantolol | The metabolism of Bevantolol can be decreased when combined with Rhein. |
| Practolol | The metabolism of Practolol can be decreased when combined with Rhein. |
| Penbutolol | The metabolism of Penbutolol can be decreased when combined with Rhein. |
| Yohimbine | The metabolism of Yohimbine can be decreased when combined with Rhein. |