Peringatan Keamanan

Single oral doses of plecanatide at 0.5 mg/kg and 10 mg/kg caused mortality in young juvenile mice on postnatal days 7 and 14, respectively (human age equivalent of approximately 1 month to less than 2 years).

Plecanatide

DB13170

small molecule approved investigational

Deskripsi

Plecanatide is a drug approved in January 2017 by the FDA for the treatment of chronic idiopathic constipation (CIC). It should not be used in children less than six years of age, and should be avoided in patients six years to 18 years of age

Struktur Molekul 2D

Berat 1681.89
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) half-life (t½) cannot be calculated due to negligible systemic absorbance
Volume Distribusi Concentrations of plecanatide and its active metabolite in plasma are below the limit of quantitation after an oral dose of 3 mg. Therefore, the volume of distribution can not be calculated.
Klirens (Clearance) No excretion studies have been conducted in humans.

Absorpsi

Plecanatide is minimally absorbed with negligible systemic availability following oral administration. Concentrations of plecanatide and its active metabolite in plasma are below the limit of quantitation after an oral dose of 3 mg. Therefore, standard pharmacokinetic parameters such as AUC, maximum concentration (Cmax), and half-life (t½) cannot be calculated.

Metabolisme

Plecanatide is metabolized in the GI tract to an active metabolite by loss of the terminal leucine moiety. Both plecanatide and the metabolite are proteolytically degraded within the intestinal lumen to smaller peptides and naturally occurring amino acids.

Rute Eliminasi

No excretion studies have been conducted in humans. Plecanatide and its active metabolite are not measurable in plasma following administration of the recommended clinical doses.

Interaksi Makanan

1 Data
  • 1. Take with or without food.

Interaksi Obat

400 Data
Tramadol The therapeutic efficacy of Plecanatide can be decreased when used in combination with Tramadol.
Trospium The therapeutic efficacy of Plecanatide can be decreased when used in combination with Trospium.
Oxyphenonium The therapeutic efficacy of Plecanatide can be decreased when used in combination with Oxyphenonium.
Benzatropine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Benzatropine.
Ziprasidone The therapeutic efficacy of Plecanatide can be decreased when used in combination with Ziprasidone.
Disopyramide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Disopyramide.
Amitriptyline The therapeutic efficacy of Plecanatide can be decreased when used in combination with Amitriptyline.
Ipratropium The therapeutic efficacy of Plecanatide can be decreased when used in combination with Ipratropium.
Olanzapine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Olanzapine.
Metixene The therapeutic efficacy of Plecanatide can be decreased when used in combination with Metixene.
Terfenadine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Terfenadine.
Buclizine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Buclizine.
Clozapine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Clozapine.
Doxylamine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Doxylamine.
Trihexyphenidyl The therapeutic efficacy of Plecanatide can be decreased when used in combination with Trihexyphenidyl.
Oxyphencyclimine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Oxyphencyclimine.
Procyclidine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Procyclidine.
Profenamine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Profenamine.
Promazine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Promazine.
Hyoscyamine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Hyoscyamine.
Cyproheptadine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Cyproheptadine.
Imipramine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Imipramine.
Methscopolamine bromide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Methscopolamine bromide.
Chlorpromazine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Chlorpromazine.
Gallamine triethiodide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Gallamine triethiodide.
Darifenacin The therapeutic efficacy of Plecanatide can be decreased when used in combination with Darifenacin.
Tridihexethyl The therapeutic efficacy of Plecanatide can be decreased when used in combination with Tridihexethyl.
Triflupromazine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Triflupromazine.
Anisotropine methylbromide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Anisotropine methylbromide.
Nortriptyline The therapeutic efficacy of Plecanatide can be decreased when used in combination with Nortriptyline.
Amoxapine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Amoxapine.
Atropine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Atropine.
Nicardipine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Nicardipine.
Pirenzepine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Pirenzepine.
Paroxetine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Paroxetine.
Homatropine methylbromide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Homatropine methylbromide.
Rocuronium The therapeutic efficacy of Plecanatide can be decreased when used in combination with Rocuronium.
Scopolamine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Scopolamine.
Benzquinamide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Benzquinamide.
Clidinium The therapeutic efficacy of Plecanatide can be decreased when used in combination with Clidinium.
Propiomazine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Propiomazine.
Propantheline The therapeutic efficacy of Plecanatide can be decreased when used in combination with Propantheline.
Dicyclomine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Dicyclomine.
Biperiden The therapeutic efficacy of Plecanatide can be decreased when used in combination with Biperiden.
Brompheniramine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Brompheniramine.
Flupentixol The therapeutic efficacy of Plecanatide can be decreased when used in combination with Flupentixol.
Cocaine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Cocaine.
Quinidine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Quinidine.
Maprotiline The therapeutic efficacy of Plecanatide can be decreased when used in combination with Maprotiline.
Methantheline The therapeutic efficacy of Plecanatide can be decreased when used in combination with Methantheline.
Cycrimine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Cycrimine.
Glycopyrronium The therapeutic efficacy of Plecanatide can be decreased when used in combination with Glycopyrronium.
Tolterodine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Tolterodine.
Oxybutynin The therapeutic efficacy of Plecanatide can be decreased when used in combination with Oxybutynin.
Promethazine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Promethazine.
Diphenhydramine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Diphenhydramine.
Doxacurium The therapeutic efficacy of Plecanatide can be decreased when used in combination with Doxacurium.
Doxepin The therapeutic efficacy of Plecanatide can be decreased when used in combination with Doxepin.
Flavoxate The therapeutic efficacy of Plecanatide can be decreased when used in combination with Flavoxate.
Desipramine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Desipramine.
Orphenadrine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Orphenadrine.
Escitalopram The therapeutic efficacy of Plecanatide can be decreased when used in combination with Escitalopram.
Quetiapine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Quetiapine.
Mivacurium The therapeutic efficacy of Plecanatide can be decreased when used in combination with Mivacurium.
Diphenidol The therapeutic efficacy of Plecanatide can be decreased when used in combination with Diphenidol.
Aripiprazole The therapeutic efficacy of Plecanatide can be decreased when used in combination with Aripiprazole.
Chlorprothixene The therapeutic efficacy of Plecanatide can be decreased when used in combination with Chlorprothixene.
Metocurine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Metocurine.
Pancuronium The therapeutic efficacy of Plecanatide can be decreased when used in combination with Pancuronium.
Pipecuronium The therapeutic efficacy of Plecanatide can be decreased when used in combination with Pipecuronium.
Methotrimeprazine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Methotrimeprazine.
Tiotropium The therapeutic efficacy of Plecanatide can be decreased when used in combination with Tiotropium.
Solifenacin The therapeutic efficacy of Plecanatide can be decreased when used in combination with Solifenacin.
Isopropamide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Isopropamide.
Rapacuronium The therapeutic efficacy of Plecanatide can be decreased when used in combination with Rapacuronium.
Mepenzolate The therapeutic efficacy of Plecanatide can be decreased when used in combination with Mepenzolate.
Pizotifen The therapeutic efficacy of Plecanatide can be decreased when used in combination with Pizotifen.
Fesoterodine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Fesoterodine.
Hexocyclium The therapeutic efficacy of Plecanatide can be decreased when used in combination with Hexocyclium.
Dimetindene The therapeutic efficacy of Plecanatide can be decreased when used in combination with Dimetindene.
Aclidinium The therapeutic efficacy of Plecanatide can be decreased when used in combination with Aclidinium.
Dexetimide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Dexetimide.
Benactyzine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Benactyzine.
Umeclidinium The therapeutic efficacy of Plecanatide can be decreased when used in combination with Umeclidinium.
Trimebutine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Trimebutine.
Dosulepin The therapeutic efficacy of Plecanatide can be decreased when used in combination with Dosulepin.
Imidafenacin The therapeutic efficacy of Plecanatide can be decreased when used in combination with Imidafenacin.
Butylscopolamine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Butylscopolamine.
Thonzylamine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Thonzylamine.
Methscopolamine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Methscopolamine.
Revefenacin The therapeutic efficacy of Plecanatide can be decreased when used in combination with Revefenacin.
Oxitropium The therapeutic efficacy of Plecanatide can be decreased when used in combination with Oxitropium.
Propiverine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Propiverine.
Batefenterol The therapeutic efficacy of Plecanatide can be decreased when used in combination with Batefenterol.
Mebeverine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Mebeverine.
Tropatepine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Tropatepine.
Prifinium The therapeutic efficacy of Plecanatide can be decreased when used in combination with Prifinium.
Piperidolate The therapeutic efficacy of Plecanatide can be decreased when used in combination with Piperidolate.
Benzilone The therapeutic efficacy of Plecanatide can be decreased when used in combination with Benzilone.
Difemerine The therapeutic efficacy of Plecanatide can be decreased when used in combination with Difemerine.

Target Protein

Guanylyl cyclase C GUCY2C
Guanylate cyclase soluble subunit alpha-2 GUCY1A2

Referensi & Sumber

Artikel (PubMed)
  • PMID: 26016701
    Thomas RH, Luthin DR: Current and emerging treatments for irritable bowel syndrome with constipation and chronic idiopathic constipation: focus on prosecretory agents. Pharmacotherapy. 2015 Jun;35(6):613-30. doi: 10.1002/phar.1594. Epub 2015 May 27.

Contoh Produk & Brand

Produk: 3 • International brands: 0
Produk
  • Trulance
    Tablet • 3 mg • Oral • Canada • Approved
  • Trulance Immediate release
    Tablet • 3 mg/1 • Oral • US • Approved
  • Trulance Immediate release
    Tablet • 3 mg/1 • Oral • US • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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