Peringatan Keamanan

The lethal dose
orally: 1100 (mice), 1050 (rats) mg / kg ;
under the skin: 600 (mice), 630 (rats) mg / kg
intraperitoneally: 550 (mice), 530 (rats) mg / kg

Alclofenac

DB13167

small molecule approved withdrawn

Deskripsi

Alclofenac is a non-steroidal anti-inflammatory drug. It was withdrawn from the market in the United Kingdom in 1979.

Struktur Molekul 2D

Berat 226.66
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The plasma half-life varies between 1.5 and 5.5 hours.
Volume Distribusi The volume of distribution is 0.1 L / kg
Klirens (Clearance) For oral dose of 500mg: Renal clearance constant (av) 35ml/min Overall clearance constant (av) 37-69ml/min

Absorpsi

The absorption of alclofenac from the gastrointestinal tract is irregular. After oral or rectal administration maximum plasma concentrations are reached within 1-4 hours.

Metabolisme

the main metabolic product is alclofenac itself and alclofenac glucuronide

Rute Eliminasi

Alclofenac is excreted in the urine mainly as glucuronide and as unchanged active substance.

Interaksi Obat

1405 Data
Amlodipine Alclofenac may decrease the antihypertensive activities of Amlodipine.
Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Alclofenac.
Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Alclofenac.
Eletriptan The risk or severity of hypertension can be increased when Eletriptan is combined with Alclofenac.
Isoetharine The risk or severity of hypertension can be increased when Isoetharine is combined with Alclofenac.
Ziprasidone The risk or severity of hypertension can be increased when Ziprasidone is combined with Alclofenac.
Methysergide The risk or severity of hypertension can be increased when Methysergide is combined with Alclofenac.
Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Alclofenac.
Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Alclofenac.
Dihydroergotamine The risk or severity of hypertension can be increased when Dihydroergotamine is combined with Alclofenac.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Alclofenac.
Norepinephrine The risk or severity of hypertension can be increased when Norepinephrine is combined with Alclofenac.
Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Alclofenac.
Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Alclofenac.
Phenylpropanolamine The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Alclofenac.
Promazine The risk or severity of hypertension can be increased when Promazine is combined with Alclofenac.
Droperidol The risk or severity of hypertension can be increased when Droperidol is combined with Alclofenac.
Doxapram The risk or severity of hypertension can be increased when Doxapram is combined with Alclofenac.
Atropine The risk or severity of hypertension can be increased when Atropine is combined with Alclofenac.
Lisuride The risk or severity of hypertension can be increased when Lisuride is combined with Alclofenac.
Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Alclofenac.
Metaraminol The risk or severity of hypertension can be increased when Metaraminol is combined with Alclofenac.
Furazolidone The risk or severity of hypertension can be increased when Furazolidone is combined with Alclofenac.
Epinephrine The risk or severity of hypertension can be increased when Epinephrine is combined with Alclofenac.
Thioridazine The risk or severity of hypertension can be increased when Thioridazine is combined with Alclofenac.
Ergotamine The risk or severity of hypertension can be increased when Ergotamine is combined with Alclofenac.
Nicergoline The risk or severity of hypertension can be increased when Nicergoline is combined with Alclofenac.
Sufentanil The risk or severity of hypertension can be increased when Sufentanil is combined with Alclofenac.
Methoxamine The risk or severity of hypertension can be increased when Methoxamine is combined with Alclofenac.
Risperidone The risk or severity of hypertension can be increased when Risperidone is combined with Alclofenac.
Tranylcypromine The risk or severity of hypertension can be increased when Tranylcypromine is combined with Alclofenac.
Isoflurane The risk or severity of hypertension can be increased when Isoflurane is combined with Alclofenac.
Propiomazine The risk or severity of hypertension can be increased when Propiomazine is combined with Alclofenac.
Alfentanil The risk or severity of hypertension can be increased when Alfentanil is combined with Alclofenac.
Minaprine The risk or severity of hypertension can be increased when Minaprine is combined with Alclofenac.
Orciprenaline The risk or severity of hypertension can be increased when Orciprenaline is combined with Alclofenac.
Propofol The risk or severity of hypertension can be increased when Propofol is combined with Alclofenac.
Phenmetrazine The risk or severity of hypertension can be increased when Phenmetrazine is combined with Alclofenac.
Trifluoperazine The risk or severity of hypertension can be increased when Trifluoperazine is combined with Alclofenac.
Pseudoephedrine The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Alclofenac.
Benzphetamine The risk or severity of hypertension can be increased when Benzphetamine is combined with Alclofenac.
Ritodrine The risk or severity of hypertension can be increased when Ritodrine is combined with Alclofenac.
Flupentixol The risk or severity of hypertension can be increased when Flupentixol is combined with Alclofenac.
Remifentanil The risk or severity of hypertension can be increased when Remifentanil is combined with Alclofenac.
Bitolterol The risk or severity of hypertension can be increased when Bitolterol is combined with Alclofenac.
Oxymetazoline The risk or severity of hypertension can be increased when Oxymetazoline is combined with Alclofenac.
Diethylpropion The risk or severity of hypertension can be increased when Diethylpropion is combined with Alclofenac.
Salmeterol The risk or severity of hypertension can be increased when Salmeterol is combined with Alclofenac.
Naratriptan The risk or severity of hypertension can be increased when Naratriptan is combined with Alclofenac.
Formoterol The risk or severity of hypertension can be increased when Formoterol is combined with Alclofenac.
Frovatriptan The risk or severity of hypertension can be increased when Frovatriptan is combined with Alclofenac.
Methoxyflurane The risk or severity of hypertension can be increased when Methoxyflurane is combined with Alclofenac.
Selegiline The risk or severity of hypertension can be increased when Selegiline is combined with Alclofenac.
Ergoloid mesylate The risk or severity of hypertension can be increased when Ergoloid mesylate is combined with Alclofenac.
Isoprenaline The risk or severity of hypertension can be increased when Isoprenaline is combined with Alclofenac.
Arbutamine The risk or severity of hypertension can be increased when Arbutamine is combined with Alclofenac.
Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Alclofenac.
Halothane The risk or severity of hypertension can be increased when Halothane is combined with Alclofenac.
Moclobemide The risk or severity of hypertension can be increased when Moclobemide is combined with Alclofenac.
Pergolide The risk or severity of hypertension can be increased when Pergolide is combined with Alclofenac.
Desflurane The risk or severity of hypertension can be increased when Desflurane is combined with Alclofenac.
Bromocriptine The risk or severity of hypertension can be increased when Bromocriptine is combined with Alclofenac.
Finasteride The risk or severity of hypertension can be increased when Finasteride is combined with Alclofenac.
Aripiprazole The risk or severity of hypertension can be increased when Aripiprazole is combined with Alclofenac.
Isocarboxazid The risk or severity of hypertension can be increased when Isocarboxazid is combined with Alclofenac.
Ergometrine The risk or severity of hypertension can be increased when Ergometrine is combined with Alclofenac.
Lisdexamfetamine The risk or severity of hypertension can be increased when Lisdexamfetamine is combined with Alclofenac.
Fenoterol The risk or severity of hypertension can be increased when Fenoterol is combined with Alclofenac.
Pirbuterol The risk or severity of hypertension can be increased when Pirbuterol is combined with Alclofenac.
Ephedra sinica root The risk or severity of hypertension can be increased when Ephedra sinica root is combined with Alclofenac.
Ephedrine The risk or severity of hypertension can be increased when Ephedrine is combined with Alclofenac.
Mephentermine The risk or severity of hypertension can be increased when Mephentermine is combined with Alclofenac.
Procaterol The risk or severity of hypertension can be increased when Procaterol is combined with Alclofenac.
Yohimbine The risk or severity of hypertension can be increased when Yohimbine is combined with Alclofenac.
Methotrimeprazine The risk or severity of hypertension can be increased when Methotrimeprazine is combined with Alclofenac.
Clenbuterol The risk or severity of hypertension can be increased when Clenbuterol is combined with Alclofenac.
Bambuterol The risk or severity of hypertension can be increased when Bambuterol is combined with Alclofenac.
MMDA The risk or severity of hypertension can be increased when MMDA is combined with Alclofenac.
Midomafetamine The risk or severity of hypertension can be increased when Midomafetamine is combined with Alclofenac.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of hypertension can be increased when 2,5-Dimethoxy-4-ethylamphetamine is combined with Alclofenac.
4-Methoxyamphetamine The risk or severity of hypertension can be increased when 4-Methoxyamphetamine is combined with Alclofenac.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of hypertension can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with Alclofenac.
Tenamfetamine The risk or severity of hypertension can be increased when Tenamfetamine is combined with Alclofenac.
Chlorphentermine The risk or severity of hypertension can be increased when Chlorphentermine is combined with Alclofenac.
Dextroamphetamine The risk or severity of hypertension can be increased when Dextroamphetamine is combined with Alclofenac.
Phendimetrazine The risk or severity of hypertension can be increased when Phendimetrazine is combined with Alclofenac.
Solifenacin The risk or severity of hypertension can be increased when Solifenacin is combined with Alclofenac.
Periciazine The risk or severity of hypertension can be increased when Periciazine is combined with Alclofenac.
Acepromazine The risk or severity of hypertension can be increased when Acepromazine is combined with Alclofenac.
Thioproperazine The risk or severity of hypertension can be increased when Thioproperazine is combined with Alclofenac.
Zuclopenthixol The risk or severity of hypertension can be increased when Zuclopenthixol is combined with Alclofenac.
Epicaptopril The risk or severity of hypertension can be increased when Epicaptopril is combined with Alclofenac.
Clorgiline The risk or severity of hypertension can be increased when Clorgiline is combined with Alclofenac.
1-benzylimidazole The risk or severity of hypertension can be increased when 1-benzylimidazole is combined with Alclofenac.
Iproniazid The risk or severity of hypertension can be increased when Iproniazid is combined with Alclofenac.
Nialamide The risk or severity of hypertension can be increased when Nialamide is combined with Alclofenac.
Lysergic acid diethylamide The risk or severity of hypertension can be increased when Lysergic acid diethylamide is combined with Alclofenac.
Dronedarone The risk or severity of hypertension can be increased when Dronedarone is combined with Alclofenac.
Flibanserin The risk or severity of hypertension can be increased when Flibanserin is combined with Alclofenac.
Iloperidone The risk or severity of hypertension can be increased when Iloperidone is combined with Alclofenac.

Target Protein

Prostaglandin G/H synthase 2 PTGS2

Referensi & Sumber

Artikel (PubMed)
  • PMID: 241593
    Wiggins LF: The chemical and biological background to alclofenac. Curr Med Res Opin. 1975;3(5):241-8.
  • PMID: 4911592
    Lambotte F: Therapeutic activity of 4-allyloxy-3-chlorophenylacetic acid. Arzneimittelforschung. 1970 Apr;20(4):569-71.
  • PMID: 241595
    Thomas GM, Rees P, Dippy JE, Maddock J: Simultaneous pharmacokinetics of alclofenace in plasma and synovial fluid in patients with rheumatoid arthritis. Curr Med Res Opin. 1975;3(5):264-7.
  • PMID: 11318639
    Selinsky BS, Gupta K, Sharkey CT, Loll PJ: Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations. Biochemistry. 2001 May 1;40(17):5172-80.
  • PMID: 21068
    Brogden RN, Heel RC, Speight TM, Avery GS: Alclofenac: a review of its pharmacological properties and therapeutic efficacy in rheumatoid arthritis and allied rheumatic disorders. Drugs. 1977 Oct;14(4):241-59.

Contoh Produk & Brand

Produk: 0 • International brands: 8
International Brands
  • Allopydin
  • Medifenac
  • Mervan
  • Neosten
  • Neoston
  • Prinalgin
  • Reufenac
  • Zumaril

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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