Peringatan Keamanan

Organism : Mouse
Test type : LD50
Route: Intraperitoneal
Reported dose: 1900mg/kg
No reported effects known other than LD50

Esculin

DB13155

small molecule approved

Deskripsi

Esculin is found in barley. Vitamin C2 is generally considered a bioflavanoid, related to vitamin P esculin is a glucoside that naturally occurs in the horse chestnut (Aesculus hippocastanum), California Buckeye (Aesculus californica) and in daphnin (the dark green resin of Daphne mezereum). Esculin belongs to the family of Glycosyl Compounds. These are carbohydrate derivatives in which a sugar group is bonded through its anmoeric carbonA to another group via a C-, S-,N-,O-, or Se- glycosidic bond.

Struktur Molekul 2D

Berat 340.284
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Absorption half life about 1 hour and elimination half life about 20 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rarely, absorbed into the blood stream if used as a combination with other ingredients in suppository form. But, Applying cream or ointment form to open wound or skin may lead this drug to absorb and circulate into blood stream.

Metabolisme

After oral administration of esculin (100 mg/kg) for rats, plasma, urine, feces and bile samples were collected to screen metabolites. As a result, a total of 19 metabolites (10 phase I metabolites and 9 phase II metabolites) were found and identified. It was also found that after oral administration of esculin, the esculin could be metabolized to esculetin in vivo via deglycosylation, and esculetin was found in all biological samples.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

17 Data
Dexmethylphenidate The serum concentration of the active metabolites of Esculin can be increased when Esculin is used in combination with Dexmethylphenidate.
Glimepiride The therapeutic efficacy of Glimepiride can be increased when used in combination with Esculin.
Acetohexamide The therapeutic efficacy of Acetohexamide can be increased when used in combination with Esculin.
Chlorpropamide The therapeutic efficacy of Chlorpropamide can be increased when used in combination with Esculin.
Tolazamide The therapeutic efficacy of Tolazamide can be increased when used in combination with Esculin.
Glyburide The therapeutic efficacy of Glyburide can be increased when used in combination with Esculin.
Glipizide The therapeutic efficacy of Glipizide can be increased when used in combination with Esculin.
Gliclazide The therapeutic efficacy of Gliclazide can be increased when used in combination with Esculin.
Tolbutamide The therapeutic efficacy of Tolbutamide can be increased when used in combination with Esculin.
Gliquidone The therapeutic efficacy of Gliquidone can be increased when used in combination with Esculin.
Glisoxepide The therapeutic efficacy of Glisoxepide can be increased when used in combination with Esculin.
Glibornuride The therapeutic efficacy of Glibornuride can be increased when used in combination with Esculin.
Carbutamide The therapeutic efficacy of Carbutamide can be increased when used in combination with Esculin.
Metahexamide The therapeutic efficacy of Metahexamide can be increased when used in combination with Esculin.
Lepirudin The risk or severity of bleeding can be increased when Esculin is combined with Lepirudin.
Doxycycline The therapeutic efficacy of Esculin can be increased when used in combination with Doxycycline.
Diazoxide The serum concentration of Esculin can be increased when it is combined with Diazoxide.

Target Protein

Androgen receptor AR

Referensi & Sumber

Artikel (PubMed)
  • PMID: 27038404
    Wang Y, Zhao M, Ou Y, Zeng B, Lou X, Wang M, Zhao C: Metabolic profile of esculin in rats by ultra high performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 May 1;1020:120-8. doi: 10.1016/j.jchromb.2016.03.027. Epub 2016 Mar 21.

Contoh Produk & Brand

Produk: 14 • International brands: 0
Produk
  • Odan Proctomyxin HC
    Ointment • - • Rectal • Canada • Generic • Approved
  • Odan Proctomyxin HC Suppositories
    Suppository • - • Rectal • Canada • Generic • Approved
  • Proctol Ointment
    Ointment • - • Rectal • Canada • Approved
  • Proctol Suppositories
    Suppository • - • Rectal • Canada • Approved
  • Proctosedyl
    Ointment • - • Rectal • Canada • Approved
  • Proctosedyl
    Suppository • - • Rectal • Canada • Approved
  • Proctosedyl Ointment
    Ointment • - • Rectal • Canada • Approved
  • Proctosedyl Ointment
    Ointment • - • Rectal • Canada • Approved
Menampilkan 8 dari 14 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul