Levomenol

DB13153

small molecule approved experimental

Deskripsi

Bisabolol, or more formally ?-(?)-bisabolol or also known as levomenol, (-)-alpha-Bisabolol is found in fats and oils. (-)-alpha-Bisabolol is isolated from essential oil of Matricaria chamomilla (German chamomile) (-)-alpha-Bisabolol belongs to the family of Sesquiterpenes. These are terpenes with three consecutive isoprene units.

Struktur Molekul 2D

Berat 222.372
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi To demonstrate the distribution of the substance in the skin a part of this tissue was cutted into horizontal slices by a cryotome. From the slices autoradiograms were produced. The densitometric measuration showed that there was a fast penetration of levomenol into the skin. 5 h after the topical application the substance was displaced from outermost to innermost areas. From these results a fast cutaneous absorption and a long therapeutical effect of the antiphlogistic and spasmolytic levomenol in the skin can be expected.
Klirens (Clearance) -

Absorpsi

The purpose of the present investigations was to study the cutaneous absorption of sesquiterpenic alcohol, the major active principle of chamomile. For these investigations 14C-labelled levomenol ((-)-6-methyl-2-(4-methyl-3-cyclohexen-1-yl)-5-hepten-2-ol; (-)-alpha-bisabolol) was prepared by biochemical incorporation of 14C-acetate into the molecule. 5 h after topical application of the radiolabelled substance onto nude mice half of the radioactivity was found in the skin. The other part was measured in tissue and organes. 90% of this radioactivity was analysed as intact levomenol.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

9 Data
Filgotinib The serum concentration of Levomenol can be increased when it is combined with Filgotinib.
Roxadustat The serum concentration of Levomenol can be increased when it is combined with Roxadustat.
Apalutamide The serum concentration of Levomenol can be decreased when it is combined with Apalutamide.
Trofinetide The serum concentration of Levomenol can be increased when it is combined with Trofinetide.
Leniolisib The excretion of Levomenol can be decreased when combined with Leniolisib.
Elexacaftor The serum concentration of Levomenol can be increased when it is combined with Elexacaftor.
Encorafenib The serum concentration of Levomenol can be increased when it is combined with Encorafenib.
Ceftobiprole medocaril The serum concentration of Levomenol can be increased when it is combined with Ceftobiprole medocaril.
Imetelstat The serum concentration of Levomenol can be increased when it is combined with Imetelstat.

Referensi & Sumber

Contoh Produk & Brand

Produk: 7 • International brands: 0
Produk
  • IASO White Science EX Serum
    Liquid • 0.02 g/1mL • Topical • US • OTC
  • IASO White Science EX Toner
    Liquid • 0.02 g/1mL • Topical • US • OTC
  • Intense Multi Ampoule Balm Vita C
    Liquid • - • Topical • US • OTC
  • Neogen Dermalogy White Truffle Laycure Oi L
    Stick • 0.05 g/10g • Topical • US • OTC
  • NEWSTEM Rx IPL VITA C Energy Ampoule
    Liquid • - • Topical • US • OTC
  • PurpleU BAOBAB FACE
    Oil • 0.07 g/15mL • Topical • US • OTC
  • Seamoms Tamanu Oil Mist
    Oil • - • Topical • US • OTC

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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