Peringatan Keamanan

FEIBA is associated with increased risk of thromboembolic events such as stroke, myocardial infarction, and deep vein thrombosis FDA Label.

Anti-inhibitor coagulant complex

DB13151

biotech approved investigational

Deskripsi

Anti-inhibitor coagulant complex, also known as FEIBA (factor eight inhibitor bypassing activity), contains several proteins involved in the prothrombinase complex. It is used to control bleeding in hemophilia A and B patients with inhibitors.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Plasma half lives of included clotting factors are as follows [A19411]: Prothrombin - 65h Factor VII - 5h Factor IX - 25h Factor X - 40h
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

92 Data
Aminocaproic acid The risk or severity of adverse effects can be increased when Aminocaproic acid is combined with Anti-inhibitor coagulant complex.
Alpha-1-proteinase inhibitor Alpha-1-proteinase inhibitor may increase the thrombogenic activities of Anti-inhibitor coagulant complex.
Menadione Menadione may increase the thrombogenic activities of Anti-inhibitor coagulant complex.
Tranexamic acid Tranexamic acid may increase the thrombogenic activities of Anti-inhibitor coagulant complex.
Aprotinin Aprotinin may increase the thrombogenic activities of Anti-inhibitor coagulant complex.
Hydrogen peroxide Hydrogen peroxide may increase the thrombogenic activities of Anti-inhibitor coagulant complex.
Aminomethylbenzoic acid Aminomethylbenzoic acid may increase the thrombogenic activities of Anti-inhibitor coagulant complex.
Camostat Camostat may increase the thrombogenic activities of Anti-inhibitor coagulant complex.
Menadione bisulfite Menadione bisulfite may increase the thrombogenic activities of Anti-inhibitor coagulant complex.
Monteplase The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Monteplase.
Lepirudin The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Lepirudin.
Bivalirudin The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Bivalirudin.
Alteplase The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Alteplase.
Urokinase The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Urokinase.
Reteplase The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Reteplase.
Anistreplase The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Anistreplase.
Tenecteplase The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Tenecteplase.
Abciximab The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Abciximab.
Drotrecogin alfa The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Drotrecogin alfa.
Streptokinase The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Streptokinase.
Dicoumarol The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Dicoumarol.
Argatroban The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Argatroban.
Ardeparin The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Ardeparin.
Phenindione The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Phenindione.
Fondaparinux The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Fondaparinux.
Warfarin The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Warfarin.
Pentosan polysulfate The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Pentosan polysulfate.
Phenprocoumon The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Phenprocoumon.
Dipyridamole The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Dipyridamole.
Heparin The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Heparin.
Enoxaparin The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Enoxaparin.
Epoprostenol The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Epoprostenol.
Acenocoumarol The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Acenocoumarol.
4-hydroxycoumarin The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with 4-hydroxycoumarin.
Coumarin The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Coumarin.
Ximelagatran The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Ximelagatran.
Desmoteplase The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Desmoteplase.
Defibrotide The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Defibrotide.
Ancrod The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Ancrod.
Beraprost The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Beraprost.
Prasugrel The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Prasugrel.
Rivaroxaban The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Rivaroxaban.
Sulodexide The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Sulodexide.
Idraparinux The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Idraparinux.
Cangrelor The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Cangrelor.
Astaxanthin The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Astaxanthin.
Apixaban The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Apixaban.
Otamixaban The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Otamixaban.
Amediplase The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Amediplase.
Dabigatran etexilate The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Dabigatran etexilate.
Danaparoid The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Danaparoid.
Dalteparin The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Dalteparin.
Tinzaparin The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Tinzaparin.
(R)-warfarin The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with (R)-warfarin.
Ethyl biscoumacetate The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Ethyl biscoumacetate.
Nadroparin The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Nadroparin.
Triflusal The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Triflusal.
Ticagrelor The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Ticagrelor.
Ditazole The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Ditazole.
Vorapaxar The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Vorapaxar.
Edoxaban The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Edoxaban.
Sodium citrate The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Sodium citrate.
Dextran The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Dextran.
Bemiparin The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Bemiparin.
Parnaparin The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Parnaparin.
Desirudin The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Desirudin.
Antithrombin Alfa The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Antithrombin Alfa.
Protein C The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Protein C.
Antithrombin III human The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Antithrombin III human.
Letaxaban The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Letaxaban.
Darexaban The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Darexaban.
Betrixaban The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Betrixaban.
Nafamostat The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Nafamostat.
Gabexate The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Gabexate.
Fluindione The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Fluindione.
Protein S human The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Protein S human.
Brinase The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Brinase.
Clorindione The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Clorindione.
Diphenadione The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Diphenadione.
Tioclomarol The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Tioclomarol.
Melagatran The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Melagatran.
Saruplase The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Saruplase.
(S)-Warfarin The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with (S)-Warfarin.
Tocopherylquinone The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Tocopherylquinone.
Dabigatran The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Dabigatran.
Semuloparin The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Semuloparin.
Troxerutin The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Troxerutin.
Edetic acid The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Edetic acid.
Reviparin The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Reviparin.
Dermatan sulfate The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Dermatan sulfate.
SR-123781A The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with SR-123781A.
Limaprost The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Limaprost.

Target Protein

Coagulation factor X F10
Prothrombin F2
Fibrinogen alpha chain FGA
Fibrinogen beta chain FGB
Coagulation factor XIII A chain F13A1
Coagulation factor V F5
Coagulation factor VIII F8
Coagulation factor VII F7

Referensi & Sumber

Artikel (PubMed)
  • PMID: 15385040
    Turecek PL, Varadi K, Gritsch H, Schwarz HP: FEIBA: mode of action. Haemophilia. 2004 Sep;10 Suppl 2:3-9.
  • PMID: 25535411
    Palta S, Saroa R, Palta A: Overview of the coagulation system. Indian J Anaesth. 2014 Sep;58(5):515-23. doi: 10.4103/0019-5049.144643.

Contoh Produk & Brand

Produk: 11 • International brands: 0
Produk
  • Feiba
    Kit • 500 [USP'U]/20mL • Intravenous • US • Approved
  • Feiba
    Kit; Powder, for solution • 1000 U/20mL • Intravenous • US • Approved
  • Feiba
    Kit; Powder, for solution • 2500 U/50mL • Intravenous • US • Approved
  • Feiba
    Kit; Powder, for solution • 500 U/10mL • Intravenous • US • Approved
  • Feiba Nf
    Kit; Powder, for solution • 650 unit / vial • Intravenous • Canada • Approved
  • Feiba Nf
    Kit; Powder, for solution • 1300 unit / vial • Intravenous • Canada • Approved
  • Feiba Nf
    Kit • 500 [USP'U]/20mL • Intravenous • US • Approved
  • Feiba Nf
    Kit • 1000 [USP'U]/20mL • Intravenous • US • Approved
Menampilkan 8 dari 11 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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