Peringatan Keamanan

The toxic effects of nedaplatin are likely similar to those of DB00515 which produces nausea, vomiting, peripheral neuropathy, and ototoxicity A20304. A major difference between the compounds is the large reduction in nephrotoxicity of nedaplatin compared to DB00515 A20300.

Nedaplatin

DB13145

small molecule approved investigational

Deskripsi

Nedaplatin is a second generation platinum analog A20300. It is less nephrotoxic than DB00515 but has proven equally effective. It was approved for use in Japan in 1995.

Struktur Molekul 2D

Berat 303.181
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi The volume of distribution of free platinum is 12.0 L [A20307].
Klirens (Clearance) Clearance of the free platinum is 4.47 L/h [A20307].

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Most of the platinum from nedaplatin is eliminated in the urine (59.6%) A20306.

Interaksi Obat

766 Data
Topotecan The risk or severity of adverse effects can be increased when Nedaplatin is combined with Topotecan.
Phenytoin Nedaplatin can cause a decrease in the absorption of Phenytoin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Fosphenytoin Nedaplatin can cause a decrease in the absorption of Fosphenytoin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Paclitaxel The risk or severity of adverse effects can be increased when Nedaplatin is combined with Paclitaxel.
Docetaxel The risk or severity of adverse effects can be increased when Nedaplatin is combined with Docetaxel.
Cabazitaxel The risk or severity of adverse effects can be increased when Nedaplatin is combined with Cabazitaxel.
Cyclosporine Cyclosporine may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Icosapent Icosapent may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cefotiam Cefotiam may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Mesalazine Mesalazine may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cefmenoxime Cefmenoxime may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cefmetazole Cefmetazole may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Pamidronic acid Pamidronic acid may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Tenofovir disoproxil Tenofovir disoproxil may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Indomethacin Indomethacin may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cidofovir Cidofovir may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Triamterene Triamterene may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cefpiramide Cefpiramide may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Ceftazidime Ceftazidime may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Loracarbef Loracarbef may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cefalotin Cefalotin may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Nabumetone Nabumetone may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Ketorolac Ketorolac may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Tenoxicam Tenoxicam may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cefotaxime Cefotaxime may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Tolmetin Tolmetin may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Foscarnet Foscarnet may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Rofecoxib Rofecoxib may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Piroxicam Piroxicam may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Methotrexate Methotrexate may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cephalexin Cephalexin may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Fenoprofen Fenoprofen may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Valaciclovir Valaciclovir may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Valdecoxib Valdecoxib may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Diclofenac Diclofenac may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Sulindac Sulindac may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Bacitracin Bacitracin may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Amphotericin B Amphotericin B may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cephaloglycin Cephaloglycin may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Flurbiprofen Flurbiprofen may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Pentamidine Pentamidine may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Mannitol Mannitol may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Etodolac Etodolac may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Mefenamic acid Mefenamic acid may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Acyclovir Acyclovir may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Naproxen Naproxen may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Sulfasalazine Sulfasalazine may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Phenylbutazone Phenylbutazone may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Meloxicam The risk or severity of methemoglobinemia can be increased when Nedaplatin is combined with Meloxicam.
Carprofen Carprofen may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cefaclor Cefaclor may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Diflunisal Diflunisal may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Tacrolimus Tacrolimus may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Etacrynic acid Etacrynic acid may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Ceforanide Ceforanide may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Salicylic acid Salicylic acid may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Meclofenamic acid Meclofenamic acid may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Carboplatin Carboplatin may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Oxaprozin Oxaprozin may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Ketoprofen Ketoprofen may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Balsalazide Balsalazide may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Ibuprofen Ibuprofen may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cefditoren Cefditoren may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Atazanavir Atazanavir may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Colistimethate Colistimethate may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cefuroxime Cefuroxime may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cefapirin Cefapirin may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cefadroxil Cefadroxil may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cefprozil Cefprozil may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Ceftriaxone Ceftriaxone may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Olsalazine Olsalazine may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Lumiracoxib Lumiracoxib may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cefamandole Cefamandole may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cefazolin Cefazolin may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cefonicid Cefonicid may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cefoperazone Cefoperazone may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cefotetan Cefotetan may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cefoxitin Cefoxitin may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Ceftizoxime Ceftizoxime may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cefradine Cefradine may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Magnesium salicylate Magnesium salicylate may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Salsalate Salsalate may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Choline magnesium trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cefepime Cefepime may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cefacetrile Cefacetrile may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Ceftibuten Ceftibuten may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cefpodoxime Cefpodoxime may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Antrafenine Antrafenine may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Aminophenazone Aminophenazone may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Antipyrine Antipyrine may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Tiaprofenic acid Tiaprofenic acid may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Lopinavir Lopinavir may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Etoricoxib Etoricoxib may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Hydrolyzed Cephalothin Hydrolyzed Cephalothin may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Cephalothin Group Cephalothin Group may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Oxyphenbutazone Oxyphenbutazone may decrease the excretion rate of Nedaplatin which could result in a higher serum level.

Target Protein

DNA
Glutathione

Referensi & Sumber

Artikel (PubMed)
  • PMID: 20593091
    Wheate NJ, Walker S, Craig GE, Oun R: The status of platinum anticancer drugs in the clinic and in clinical trials. Dalton Trans. 2010 Sep 21;39(35):8113-27. doi: 10.1039/c0dt00292e. Epub 2010 Jun 30.
  • PMID: 27417937
    Fong CW: Platinum based radiochemotherapies: Free radical mechanisms and radiotherapy sensitizers. Free Radic Biol Med. 2016 Oct;99:99-109. doi: 10.1016/j.freeradbiomed.2016.07.006. Epub 2016 Jul 12.
  • PMID: 26886018
    Dilruba S, Kalayda GV: Platinum-based drugs: past, present and future. Cancer Chemother Pharmacol. 2016 Jun;77(6):1103-24. doi: 10.1007/s00280-016-2976-z. Epub 2016 Feb 17.
  • PMID: 2647312
    Sasaki Y, Tamura T, Eguchi K, Shinkai T, Fujiwara Y, Fukuda M, Ohe Y, Bungo M, Horichi N, Niimi S, et al.: Pharmacokinetics of (glycolate-0,0')-diammine platinum (II), a new platinum derivative, in comparison with cisplatin and carboplatin. Cancer Chemother Pharmacol. 1989;23(4):243-6.
  • PMID: 12895194
    Ishibashi T, Yano Y, Oguma T: Population pharmacokinetics of platinum after nedaplatin administration and model validation in adult patients. Br J Clin Pharmacol. 2003 Aug;56(2):205-13.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
  • Aqupla — Shionogi & Co., Ltd

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul