Peringatan Keamanan

Assess patient for nausea, vomiting, anorexia, thirst, severe constipation, paralytic ileus, and bradycardia

Calcium glubionate anhydrous

DB13142

small molecule approved

Deskripsi

Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets.

Struktur Molekul 2D

Berat 592.513
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi Primarily in bones, teeth
Klirens (Clearance) -

Absorpsi

Minimal unless chronic, high doses; absorption predominantly in the duodenum and dependent on calcitriol and vitamin D; mean absorption of calcium intake varies with age (infants 60%, prepubertal children 28%, pubertal children 34%, adults 25%); during pregnancy, calcium absorption doubles; calcium is absorbed in soluble, ionized form; solubility of calcium is increased in an acid environment (IOM 2011); decreased absorption occurs in patients with achlorhydria, renal osteodystrophy, steatorrhea, or uremia

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Primarily feces (75%; as unabsorbed calcium); urine (22%)

Interaksi Obat

184 Data
Ceftriaxone The risk or severity of adverse effects can be increased when Calcium glubionate anhydrous is combined with Ceftriaxone.
Dobutamine The therapeutic efficacy of Dobutamine can be decreased when used in combination with Calcium glubionate anhydrous.
Calcium acetate The risk or severity of adverse effects can be increased when Calcium glubionate anhydrous is combined with Calcium acetate.
Digoxin Calcium glubionate anhydrous may increase the arrhythmogenic and cardiotoxic activities of Digoxin.
Acetyldigitoxin Calcium glubionate anhydrous may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin.
Deslanoside Calcium glubionate anhydrous may increase the arrhythmogenic and cardiotoxic activities of Deslanoside.
Ouabain Calcium glubionate anhydrous may increase the arrhythmogenic and cardiotoxic activities of Ouabain.
Digitoxin Calcium glubionate anhydrous may increase the arrhythmogenic and cardiotoxic activities of Digitoxin.
Oleandrin Calcium glubionate anhydrous may increase the arrhythmogenic and cardiotoxic activities of Oleandrin.
Cymarin Calcium glubionate anhydrous may increase the arrhythmogenic and cardiotoxic activities of Cymarin.
Proscillaridin Calcium glubionate anhydrous may increase the arrhythmogenic and cardiotoxic activities of Proscillaridin.
Metildigoxin Calcium glubionate anhydrous may increase the arrhythmogenic and cardiotoxic activities of Metildigoxin.
Lanatoside C Calcium glubionate anhydrous may increase the arrhythmogenic and cardiotoxic activities of Lanatoside C.
Gitoformate Calcium glubionate anhydrous may increase the arrhythmogenic and cardiotoxic activities of Gitoformate.
Acetyldigoxin Calcium glubionate anhydrous may increase the arrhythmogenic and cardiotoxic activities of Acetyldigoxin.
Peruvoside Calcium glubionate anhydrous may increase the arrhythmogenic and cardiotoxic activities of Peruvoside.
Doxycycline The serum concentration of Doxycycline can be decreased when it is combined with Calcium glubionate anhydrous.
Lymecycline The serum concentration of Lymecycline can be decreased when it is combined with Calcium glubionate anhydrous.
Clomocycline The serum concentration of Clomocycline can be decreased when it is combined with Calcium glubionate anhydrous.
Oxytetracycline The serum concentration of Oxytetracycline can be decreased when it is combined with Calcium glubionate anhydrous.
Demeclocycline The serum concentration of Demeclocycline can be decreased when it is combined with Calcium glubionate anhydrous.
Tetracycline The serum concentration of Tetracycline can be decreased when it is combined with Calcium glubionate anhydrous.
Metacycline The serum concentration of Metacycline can be decreased when it is combined with Calcium glubionate anhydrous.
Minocycline The serum concentration of Minocycline can be decreased when it is combined with Calcium glubionate anhydrous.
Sarecycline The serum concentration of Sarecycline can be decreased when it is combined with Calcium glubionate anhydrous.
Omadacycline The serum concentration of Omadacycline can be decreased when it is combined with Calcium glubionate anhydrous.
Penimepicycline The serum concentration of Penimepicycline can be decreased when it is combined with Calcium glubionate anhydrous.
Methyclothiazide Methyclothiazide may decrease the excretion rate of Calcium glubionate anhydrous which could result in a higher serum level.
Chlorthalidone Chlorthalidone may decrease the excretion rate of Calcium glubionate anhydrous which could result in a higher serum level.
Bendroflumethiazide Bendroflumethiazide may decrease the excretion rate of Calcium glubionate anhydrous which could result in a higher serum level.
Metolazone Metolazone may decrease the excretion rate of Calcium glubionate anhydrous which could result in a higher serum level.
Benzthiazide Benzthiazide may decrease the excretion rate of Calcium glubionate anhydrous which could result in a higher serum level.
Hydroflumethiazide Hydroflumethiazide may decrease the excretion rate of Calcium glubionate anhydrous which could result in a higher serum level.
Indapamide Indapamide may decrease the excretion rate of Calcium glubionate anhydrous which could result in a higher serum level.
Chlorothiazide Chlorothiazide may decrease the excretion rate of Calcium glubionate anhydrous which could result in a higher serum level.
Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Calcium glubionate anhydrous which could result in a higher serum level.
Trichlormethiazide Trichlormethiazide may decrease the excretion rate of Calcium glubionate anhydrous which could result in a higher serum level.
Polythiazide Polythiazide may decrease the excretion rate of Calcium glubionate anhydrous which could result in a higher serum level.
Quinethazone Quinethazone may decrease the excretion rate of Calcium glubionate anhydrous which could result in a higher serum level.
Cyclopenthiazide Cyclopenthiazide may decrease the excretion rate of Calcium glubionate anhydrous which could result in a higher serum level.
Epitizide Epitizide may decrease the excretion rate of Calcium glubionate anhydrous which could result in a higher serum level.
Calcitriol The risk or severity of adverse effects can be increased when Calcitriol is combined with Calcium glubionate anhydrous.
Calcifediol The risk or severity of adverse effects can be increased when Calcifediol is combined with Calcium glubionate anhydrous.
Ergocalciferol The risk or severity of adverse effects can be increased when Ergocalciferol is combined with Calcium glubionate anhydrous.
Cholecalciferol The risk or severity of adverse effects can be increased when Cholecalciferol is combined with Calcium glubionate anhydrous.
Paricalcitol The risk or severity of adverse effects can be increased when Paricalcitol is combined with Calcium glubionate anhydrous.
Dihydrotachysterol The risk or severity of adverse effects can be increased when Dihydrotachysterol is combined with Calcium glubionate anhydrous.
Alfacalcidol The risk or severity of adverse effects can be increased when Alfacalcidol is combined with Calcium glubionate anhydrous.
Calcipotriol The risk or severity of adverse effects can be increased when Calcipotriol is combined with Calcium glubionate anhydrous.
Seocalcitol The risk or severity of adverse effects can be increased when Seocalcitol is combined with Calcium glubionate anhydrous.
Inecalcitol The risk or severity of adverse effects can be increased when Inecalcitol is combined with Calcium glubionate anhydrous.
Becocalcidiol The risk or severity of adverse effects can be increased when Becocalcidiol is combined with Calcium glubionate anhydrous.
Eldecalcitol The risk or severity of adverse effects can be increased when Eldecalcitol is combined with Calcium glubionate anhydrous.
1alpha,24S-Dihydroxyvitamin D2 The risk or severity of adverse effects can be increased when 1alpha,24S-Dihydroxyvitamin D2 is combined with Calcium glubionate anhydrous.
Elocalcitol The risk or severity of adverse effects can be increased when Elocalcitol is combined with Calcium glubionate anhydrous.
Maxacalcitol The risk or severity of adverse effects can be increased when Maxacalcitol is combined with Calcium glubionate anhydrous.
Doxercalciferol The risk or severity of adverse effects can be increased when Doxercalciferol is combined with Calcium glubionate anhydrous.
Vitamin D The risk or severity of adverse effects can be increased when Vitamin D is combined with Calcium glubionate anhydrous.
1alpha-Hydroxyvitamin D5 The risk or severity of adverse effects can be increased when 1alpha-Hydroxyvitamin D5 is combined with Calcium glubionate anhydrous.
Tacalcitol The risk or severity of adverse effects can be increased when Tacalcitol is combined with Calcium glubionate anhydrous.
Previtamin D(3) The risk or severity of adverse effects can be increased when Previtamin D(3) is combined with Calcium glubionate anhydrous.
Isradipine The therapeutic efficacy of Isradipine can be decreased when used in combination with Calcium glubionate anhydrous.
Diltiazem The therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium glubionate anhydrous.
Trimethadione The therapeutic efficacy of Trimethadione can be decreased when used in combination with Calcium glubionate anhydrous.
Amlodipine The therapeutic efficacy of Amlodipine can be decreased when used in combination with Calcium glubionate anhydrous.
Nimodipine The therapeutic efficacy of Nimodipine can be decreased when used in combination with Calcium glubionate anhydrous.
Nisoldipine The therapeutic efficacy of Nisoldipine can be decreased when used in combination with Calcium glubionate anhydrous.
Lercanidipine The therapeutic efficacy of Lercanidipine can be decreased when used in combination with Calcium glubionate anhydrous.
Cinnarizine The therapeutic efficacy of Cinnarizine can be decreased when used in combination with Calcium glubionate anhydrous.
Ethosuximide The therapeutic efficacy of Ethosuximide can be decreased when used in combination with Calcium glubionate anhydrous.
Nicardipine The therapeutic efficacy of Nicardipine can be decreased when used in combination with Calcium glubionate anhydrous.
Magnesium sulfate The therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium glubionate anhydrous.
Verapamil The therapeutic efficacy of Verapamil can be decreased when used in combination with Calcium glubionate anhydrous.
Zonisamide The therapeutic efficacy of Zonisamide can be decreased when used in combination with Calcium glubionate anhydrous.
Felodipine The therapeutic efficacy of Felodipine can be decreased when used in combination with Calcium glubionate anhydrous.
Nitrendipine The therapeutic efficacy of Nitrendipine can be decreased when used in combination with Calcium glubionate anhydrous.
Perhexiline The therapeutic efficacy of Perhexiline can be decreased when used in combination with Calcium glubionate anhydrous.
Nifedipine The therapeutic efficacy of Nifedipine can be decreased when used in combination with Calcium glubionate anhydrous.
Amiodarone The therapeutic efficacy of Amiodarone can be decreased when used in combination with Calcium glubionate anhydrous.
Carvedilol The therapeutic efficacy of Carvedilol can be decreased when used in combination with Calcium glubionate anhydrous.
Bepridil The therapeutic efficacy of Bepridil can be decreased when used in combination with Calcium glubionate anhydrous.
Mibefradil The therapeutic efficacy of Mibefradil can be decreased when used in combination with Calcium glubionate anhydrous.
Nimesulide The therapeutic efficacy of Nimesulide can be decreased when used in combination with Calcium glubionate anhydrous.
Prenylamine The therapeutic efficacy of Prenylamine can be decreased when used in combination with Calcium glubionate anhydrous.
Cyclandelate The therapeutic efficacy of Cyclandelate can be decreased when used in combination with Calcium glubionate anhydrous.
Flunarizine The therapeutic efficacy of Flunarizine can be decreased when used in combination with Calcium glubionate anhydrous.
Fluspirilene The therapeutic efficacy of Fluspirilene can be decreased when used in combination with Calcium glubionate anhydrous.
Clevidipine The therapeutic efficacy of Clevidipine can be decreased when used in combination with Calcium glubionate anhydrous.
Methsuximide The therapeutic efficacy of Methsuximide can be decreased when used in combination with Calcium glubionate anhydrous.
Seletracetam The therapeutic efficacy of Seletracetam can be decreased when used in combination with Calcium glubionate anhydrous.
Nylidrin The therapeutic efficacy of Nylidrin can be decreased when used in combination with Calcium glubionate anhydrous.
Ziconotide The therapeutic efficacy of Ziconotide can be decreased when used in combination with Calcium glubionate anhydrous.
Dotarizine The therapeutic efficacy of Dotarizine can be decreased when used in combination with Calcium glubionate anhydrous.
Xylometazoline The therapeutic efficacy of Xylometazoline can be decreased when used in combination with Calcium glubionate anhydrous.
Nilvadipine The therapeutic efficacy of Nilvadipine can be decreased when used in combination with Calcium glubionate anhydrous.
Tranilast The therapeutic efficacy of Tranilast can be decreased when used in combination with Calcium glubionate anhydrous.
Fasudil The therapeutic efficacy of Fasudil can be decreased when used in combination with Calcium glubionate anhydrous.
Agmatine The therapeutic efficacy of Agmatine can be decreased when used in combination with Calcium glubionate anhydrous.
Fendiline The therapeutic efficacy of Fendiline can be decreased when used in combination with Calcium glubionate anhydrous.
Eperisone The therapeutic efficacy of Eperisone can be decreased when used in combination with Calcium glubionate anhydrous.

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