Levosalbutamol

DB13139

small molecule approved investigational

Deskripsi

Levosalbutamol, or levalbuterol, is a short-acting ?2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Salbutamol has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective disposition of salbutamol and the possibility that (S)-salbutamol has adverse effects have led to the development of an enantiomerically pure (R)-salbutamol formulation known as levosalbutamol (levalbuterol).

Struktur Molekul 2D

Berat 239.3107
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 3.3 - 4 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Inhalation delivers the medication directly into the airways and lungs, thereby minimizing side effects because of reduced systemic absorption of the inhaled medications.

Metabolisme

Pure (R)-salbutamol formulation known as levosalbutamol is metabolised up to 12 times faster than (S)-salbutamol by intestine.

Rute Eliminasi

excreted into the urine.

Interaksi Obat

1374 Data
Loxapine The therapeutic efficacy of Levosalbutamol can be decreased when used in combination with Loxapine.
Ramipril Levosalbutamol may decrease the antihypertensive activities of Ramipril.
Remikiren Levosalbutamol may decrease the antihypertensive activities of Remikiren.
Olmesartan Levosalbutamol may decrease the antihypertensive activities of Olmesartan.
Minoxidil Levosalbutamol may decrease the antihypertensive activities of Minoxidil.
Treprostinil Levosalbutamol may decrease the antihypertensive activities of Treprostinil.
Trandolapril Levosalbutamol may decrease the antihypertensive activities of Trandolapril.
Benazepril Levosalbutamol may decrease the antihypertensive activities of Benazepril.
Candoxatril Levosalbutamol may decrease the antihypertensive activities of Candoxatril.
Moexipril Levosalbutamol may decrease the antihypertensive activities of Moexipril.
Nitroglycerin Levosalbutamol may decrease the antihypertensive activities of Nitroglycerin.
Metyrosine Levosalbutamol may decrease the antihypertensive activities of Metyrosine.
Cryptenamine Levosalbutamol may decrease the antihypertensive activities of Cryptenamine.
Candesartan cilexetil Levosalbutamol may decrease the antihypertensive activities of Candesartan cilexetil.
Eprosartan Levosalbutamol may decrease the antihypertensive activities of Eprosartan.
Quinapril Levosalbutamol may decrease the antihypertensive activities of Quinapril.
Telmisartan Levosalbutamol may decrease the antihypertensive activities of Telmisartan.
Irbesartan Levosalbutamol may decrease the antihypertensive activities of Irbesartan.
Deserpidine Levosalbutamol may decrease the antihypertensive activities of Deserpidine.
Pentolinium Levosalbutamol may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Levosalbutamol may decrease the antihypertensive activities of Trimethaphan.
Cilazapril Levosalbutamol may decrease the antihypertensive activities of Cilazapril.
Saprisartan Levosalbutamol may decrease the antihypertensive activities of Saprisartan.
Spirapril Levosalbutamol may decrease the antihypertensive activities of Spirapril.
Sitaxentan Levosalbutamol may decrease the antihypertensive activities of Sitaxentan.
Diethylnorspermine Levosalbutamol may decrease the antihypertensive activities of Diethylnorspermine.
Temocapril Levosalbutamol may decrease the antihypertensive activities of Temocapril.
Hexamethonium Levosalbutamol may decrease the antihypertensive activities of Hexamethonium.
Rauwolfia serpentina root Levosalbutamol may decrease the antihypertensive activities of Rauwolfia serpentina root.
Angiotensin 1-7 Levosalbutamol may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Levosalbutamol may decrease the antihypertensive activities of Imidapril.
BQ-123 Levosalbutamol may decrease the antihypertensive activities of BQ-123.
Dihydralazine Levosalbutamol may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Levosalbutamol may decrease the antihypertensive activities of Zofenopril.
Guanoxan Levosalbutamol may decrease the antihypertensive activities of Guanoxan.
Delapril Levosalbutamol may decrease the antihypertensive activities of Delapril.
Vincamine Levosalbutamol may decrease the antihypertensive activities of Vincamine.
Linsidomine Levosalbutamol may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Levosalbutamol may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Levosalbutamol may decrease the antihypertensive activities of Tolonidine.
Endralazine Levosalbutamol may decrease the antihypertensive activities of Endralazine.
Cadralazine Levosalbutamol may decrease the antihypertensive activities of Cadralazine.
Bietaserpine Levosalbutamol may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Levosalbutamol may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Levosalbutamol may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Levosalbutamol may decrease the antihypertensive activities of Guanoclor.
Tocopherylquinone Levosalbutamol may decrease the antihypertensive activities of Tocopherylquinone.
Benazeprilat Levosalbutamol may decrease the antihypertensive activities of Benazeprilat.
Fosinoprilat Levosalbutamol may decrease the antihypertensive activities of Fosinoprilat.
Ramiprilat Levosalbutamol may decrease the antihypertensive activities of Ramiprilat.
Perindoprilat Levosalbutamol may decrease the antihypertensive activities of Perindoprilat.
Quinaprilat Levosalbutamol may decrease the antihypertensive activities of Quinaprilat.
Enalapril Levosalbutamol may decrease the antihypertensive activities of Enalapril.
Captopril Levosalbutamol may decrease the antihypertensive activities of Captopril.
Amlodipine Levosalbutamol may decrease the antihypertensive activities of Amlodipine.
Nimodipine Levosalbutamol may decrease the antihypertensive activities of Nimodipine.
Lercanidipine Levosalbutamol may decrease the antihypertensive activities of Lercanidipine.
Bosentan Levosalbutamol may decrease the antihypertensive activities of Bosentan.
Losartan Levosalbutamol may decrease the antihypertensive activities of Losartan.
Felodipine Levosalbutamol may decrease the antihypertensive activities of Felodipine.
Nitrendipine Levosalbutamol may decrease the antihypertensive activities of Nitrendipine.
Mibefradil Levosalbutamol may decrease the antihypertensive activities of Mibefradil.
Ambrisentan Levosalbutamol may decrease the antihypertensive activities of Ambrisentan.
Nilvadipine Levosalbutamol may decrease the antihypertensive activities of Nilvadipine.
Pinacidil Levosalbutamol may decrease the antihypertensive activities of Pinacidil.
Riociguat Levosalbutamol may decrease the antihypertensive activities of Riociguat.
Aliskiren Levosalbutamol may decrease the antihypertensive activities of Aliskiren.
Lacidipine Levosalbutamol may decrease the antihypertensive activities of Lacidipine.
Manidipine Levosalbutamol may decrease the antihypertensive activities of Manidipine.
Selexipag Levosalbutamol may decrease the antihypertensive activities of Selexipag.
Naftopidil Levosalbutamol may decrease the antihypertensive activities of Naftopidil.
Tetrahydropalmatine Levosalbutamol may decrease the antihypertensive activities of Tetrahydropalmatine.
Dexniguldipine Levosalbutamol may decrease the antihypertensive activities of Dexniguldipine.
Levamlodipine Levosalbutamol may decrease the antihypertensive activities of Levamlodipine.
Diltiazem Levosalbutamol may decrease the antihypertensive activities of Diltiazem.
Clonidine Levosalbutamol may decrease the antihypertensive activities of Clonidine.
Bepridil Levosalbutamol may decrease the antihypertensive activities of Bepridil.
Debrisoquine Levosalbutamol may decrease the antihypertensive activities of Debrisoquine.
Azilsartan medoxomil Levosalbutamol may decrease the antihypertensive activities of Azilsartan medoxomil.
Diazoxide Levosalbutamol may decrease the antihypertensive activities of Diazoxide.
Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Levosalbutamol.
Bethanidine Levosalbutamol may decrease the antihypertensive activities of Bethanidine.
Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Levosalbutamol.
Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Levosalbutamol.
Doxapram The risk or severity of hypertension can be increased when Doxapram is combined with Levosalbutamol.
Atropine The risk or severity of hypertension can be increased when Atropine is combined with Levosalbutamol.
Metaraminol The risk or severity of hypertension can be increased when Metaraminol is combined with Levosalbutamol.
Guanabenz Levosalbutamol may decrease the antihypertensive activities of Guanabenz.
Methoxamine The risk or severity of hypertension can be increased when Methoxamine is combined with Levosalbutamol.
Isoflurane The risk or severity of hypertension can be increased when Isoflurane is combined with Levosalbutamol.
Propofol The risk or severity of hypertension can be increased when Propofol is combined with Levosalbutamol.
Phenmetrazine The risk or severity of hypertension can be increased when Phenmetrazine is combined with Levosalbutamol.
Pseudoephedrine The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Levosalbutamol.
Omapatrilat Levosalbutamol may decrease the antihypertensive activities of Omapatrilat.
Remifentanil The risk or severity of hypertension can be increased when Remifentanil is combined with Levosalbutamol.
Oxymetazoline The risk or severity of hypertension can be increased when Oxymetazoline is combined with Levosalbutamol.
Diethylpropion The risk or severity of hypertension can be increased when Diethylpropion is combined with Levosalbutamol.
Naratriptan The risk or severity of hypertension can be increased when Naratriptan is combined with Levosalbutamol.
Frovatriptan The risk or severity of hypertension can be increased when Frovatriptan is combined with Levosalbutamol.
Rescinnamine Levosalbutamol may decrease the antihypertensive activities of Rescinnamine.

Target Protein

Beta-2 adrenergic receptor ADRB2

Referensi & Sumber

Artikel (PubMed)
  • PMID: 11236808
    Boulton DW, Fawcett JP: The pharmacokinetics of levosalbutamol: what are the clinical implications? Clin Pharmacokinet. 2001 Jan;40(1):23-40.

Contoh Produk & Brand

Produk: 86 • International brands: 0
Produk
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    Solution • 0.63 mg/3mL • Respiratory (inhalation) • US • Generic • Approved
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    Solution • 1.25 mg/3mL • Respiratory (inhalation) • US • Generic • Approved
  • Levalbuterol
    Solution • 1.25 mg/3mL • Respiratory (inhalation) • US • Generic • Approved
  • Levalbuterol
    Solution • 0.63 mg/3mL • Respiratory (inhalation) • US • Generic • Approved
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    Solution • 0.31 mg/3mL • Respiratory (inhalation) • US • Generic • Approved
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    Solution • 0.63 mg/3mL • Respiratory (inhalation) • US • Generic • Approved
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Menampilkan 8 dari 86 produk.

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