Peringatan Keamanan

Oral LD50 of 6443mg/kg in rats MSDS.

Meclocycline

DB13092

small molecule investigational

Deskripsi

Meclocycline is under investigation in clinical trial NCT00385515 (Efficacy of SNX-1012 in the Treatment of Oral Mucositis) L797.

Struktur Molekul 2D

Berat 476.87
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Half life estimated to be ~5.6h based on that of chlortetracycline due to structural similarity [A1424].
Volume Distribusi Estimated Vd of 121L based on that of demeclocycline due to structural similarity [A1424].
Klirens (Clearance) -

Absorpsi

Estimated oral bioavailability of ~66% and tmax of 4h based on that of demeclocycline due to structural similarity A1424.

Metabolisme

Most tetracyclines are not metabolized. It is unlikely that meclocycline would be metabolized A1424.

Rute Eliminasi

Estimated urinary excretion of ~40% and fecal excretion of ~43% based on that of demeclocycline due to structural similarity A1424.

Interaksi Obat

42 Data
Methoxyflurane The risk or severity of renal failure can be increased when Methoxyflurane is combined with Meclocycline.
Magnesium Magnesium can cause a decrease in the absorption of Meclocycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Vibrio cholerae CVD 103-HgR strain live antigen The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Meclocycline.
Didanosine Didanosine can cause a decrease in the absorption of Meclocycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Collagenase clostridium histolyticum The therapeutic efficacy of Collagenase clostridium histolyticum can be decreased when used in combination with Meclocycline.
Estetrol The therapeutic efficacy of Estetrol can be decreased when used in combination with Meclocycline.
Palovarotene The risk or severity of pseudotumor cerebri can be increased when Meclocycline is combined with Palovarotene.
Lidocaine The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Lidocaine.
Ropivacaine The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Ropivacaine.
Bupivacaine The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Bupivacaine.
Cinchocaine The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Cinchocaine.
Dyclonine The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Dyclonine.
Procaine The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Procaine.
Prilocaine The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Prilocaine.
Proparacaine The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Proparacaine.
Meloxicam The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Meloxicam.
Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Oxybuprocaine.
Cocaine The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Cocaine.
Mepivacaine The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Mepivacaine.
Levobupivacaine The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Levobupivacaine.
Diphenhydramine The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Diphenhydramine.
Benzocaine The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Benzocaine.
Chloroprocaine The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Chloroprocaine.
Phenol The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Phenol.
Tetrodotoxin The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Tetrodotoxin.
Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Benzyl alcohol.
Capsaicin The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Capsaicin.
Etidocaine The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Etidocaine.
Articaine The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Articaine.
Tetracaine The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Tetracaine.
Propoxycaine The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Propoxycaine.
Pramocaine The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Pramocaine.
Butamben The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Butamben.
Butacaine The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Butacaine.
Oxetacaine The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Oxetacaine.
Ethyl chloride The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Ethyl chloride.
Butanilicaine The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Butanilicaine.
Metabutethamine The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Metabutethamine.
Quinisocaine The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Quinisocaine.
Cisatracurium Meclocycline may increase the neuromuscular blocking activities of Cisatracurium.
Ambroxol The risk or severity of methemoglobinemia can be increased when Meclocycline is combined with Ambroxol.
Fecal microbiota The therapeutic efficacy of Fecal microbiota can be decreased when used in combination with Meclocycline.

Target Protein

30S ribosomal protein S7 rpsG

Referensi & Sumber

Artikel (PubMed)
  • PMID: 11381101
    Chopra I, Roberts M: Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol Mol Biol Rev. 2001 Jun;65(2):232-60 ; second page, table of contents.
  • PMID: 16816396
    Agwuh KN, MacGowan A: Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines. J Antimicrob Chemother. 2006 Aug;58(2):256-65. Epub 2006 Jul 1.

Contoh Produk & Brand

Produk: 0 • International brands: 0
Belum ada data produk/brand untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field produk/brand.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul