Acute oral LD50, acute dermal LD50, and acute inhalation LD50 for 4 hours in rat are >5000 mg/kg, >2000 mg/kg, and >5.16 mg/m^3, respectively MSDS.

While individuals experiencing mild to moderate silver toxicity remain asymptomatic, chronic inhalation has been associated with mild chronic bronchitis and rare cases of exposure to large amounts of silver have been associated with symptoms of peripheral neuropathy, decreased mental status, and seizures ^L2853. Argyria is a detoxification mechanism for excess silver where the body sequesters and deposits excess silver in the blood vessels and connective tissue to render it in the form of silver protein complexes or silver sulphide A33141, L2853. The development of argyria through occupational exposure is reported to be a slow process ^L2853. While argyria does not cause significant pathological damage in any tissue ^A33138, heavy deposition of insoluble silver precipitates can cause discoloration or blue-grey darkening of the eyes, nasal septum, throat, skin, and other internal organs following repeated exposure ^L2853. Signs from prolonged intake of low doses of silver compound may include fatty degeneration of the liver and kidneys, and changes in blood cells ^A33141. Silver may cause metal fume fever, and colloidal silver preparations are known to exert harmful effects in humans ^L2853.