Oleandrin

DB12843

small molecule experimental investigational

Deskripsi

Oleandrin has been used in trials studying the treatment of Lung Cancer and Chemotherapeutic Agent Toxicity.

Struktur Molekul 2D

Berat 576.727
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

363 Data
Amiodarone The serum concentration of Oleandrin can be increased when it is combined with Amiodarone.
Amphotericin B The risk or severity of adverse effects can be increased when Amphotericin B is combined with Oleandrin.
Clonidine Clonidine may increase the atrioventricular blocking (AV block) activities of Oleandrin.
Edrophonium Edrophonium may increase the atrioventricular blocking (AV block) and arrhythmogenic activities of Oleandrin.
Itraconazole The serum concentration of Oleandrin can be increased when it is combined with Itraconazole.
Kaolin The serum concentration of Oleandrin can be decreased when it is combined with Kaolin.
Midodrine Oleandrin may increase the bradycardic, atrioventricular blocking (AV block), and arrhythmogenic activities of Midodrine.
Propafenone The serum concentration of Oleandrin can be increased when it is combined with Propafenone.
Quinine The serum concentration of Oleandrin can be increased when it is combined with Quinine.
Quinidine The serum concentration of Oleandrin can be increased when it is combined with Quinidine.
Reserpine The risk or severity of adverse effects can be increased when Reserpine is combined with Oleandrin.
Telmisartan The serum concentration of Oleandrin can be increased when it is combined with Telmisartan.
Tolevamer The risk or severity of Cardiac Arrhythmia can be increased when Tolevamer is combined with Oleandrin.
Sulpiride The risk or severity of QTc prolongation can be increased when Sulpiride is combined with Oleandrin.
Parathyroid hormone The risk or severity of adverse effects can be increased when Parathyroid hormone is combined with Oleandrin.
Calcitriol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Calcitriol is combined with Oleandrin.
Calcifediol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Calcifediol is combined with Oleandrin.
Ergocalciferol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Ergocalciferol is combined with Oleandrin.
Cholecalciferol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Cholecalciferol is combined with Oleandrin.
Paricalcitol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Paricalcitol is combined with Oleandrin.
Dihydrotachysterol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Dihydrotachysterol is combined with Oleandrin.
Alfacalcidol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Alfacalcidol is combined with Oleandrin.
Seocalcitol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Seocalcitol is combined with Oleandrin.
Inecalcitol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Inecalcitol is combined with Oleandrin.
Becocalcidiol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Becocalcidiol is combined with Oleandrin.
Eldecalcitol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Eldecalcitol is combined with Oleandrin.
1alpha,24S-Dihydroxyvitamin D2 The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when 1alpha,24S-Dihydroxyvitamin D2 is combined with Oleandrin.
Elocalcitol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Elocalcitol is combined with Oleandrin.
Maxacalcitol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Maxacalcitol is combined with Oleandrin.
Doxercalciferol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Doxercalciferol is combined with Oleandrin.
Vitamin D The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Vitamin D is combined with Oleandrin.
1alpha-Hydroxyvitamin D5 The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when 1alpha-Hydroxyvitamin D5 is combined with Oleandrin.
Previtamin D(3) The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Previtamin D(3) is combined with Oleandrin.
Esmolol Esmolol may increase the bradycardic activities of Oleandrin.
Betaxolol Betaxolol may increase the bradycardic activities of Oleandrin.
Metoprolol Metoprolol may increase the bradycardic activities of Oleandrin.
Atenolol Atenolol may increase the bradycardic activities of Oleandrin.
Timolol Timolol may increase the bradycardic activities of Oleandrin.
Sotalol Sotalol may increase the bradycardic activities of Oleandrin.
Propranolol Propranolol may increase the bradycardic activities of Oleandrin.
Labetalol Labetalol may increase the bradycardic activities of Oleandrin.
Bisoprolol Bisoprolol may increase the bradycardic activities of Oleandrin.
Alprenolol Alprenolol may increase the bradycardic activities of Oleandrin.
Pindolol Pindolol may increase the bradycardic activities of Oleandrin.
Carvedilol Carvedilol may increase the bradycardic activities of Oleandrin.
Acebutolol Acebutolol may increase the bradycardic activities of Oleandrin.
Nadolol Nadolol may increase the bradycardic activities of Oleandrin.
Bevantolol Bevantolol may increase the bradycardic activities of Oleandrin.
Practolol Practolol may increase the bradycardic activities of Oleandrin.
Penbutolol Penbutolol may increase the bradycardic activities of Oleandrin.
Oxprenolol Oxprenolol may increase the bradycardic activities of Oleandrin.
Dexpropranolol Dexpropranolol may increase the bradycardic activities of Oleandrin.
Celiprolol Celiprolol may increase the bradycardic activities of Oleandrin.
Nebivolol Nebivolol may increase the bradycardic activities of Oleandrin.
Bufuralol Bufuralol may increase the bradycardic activities of Oleandrin.
Bopindolol Bopindolol may increase the bradycardic activities of Oleandrin.
Bupranolol Bupranolol may increase the bradycardic activities of Oleandrin.
Indenolol Indenolol may increase the bradycardic activities of Oleandrin.
Arotinolol Arotinolol may increase the bradycardic activities of Oleandrin.
Levobetaxolol Levobetaxolol may increase the bradycardic activities of Oleandrin.
Talinolol Talinolol may increase the bradycardic activities of Oleandrin.
Anisodamine Anisodamine may increase the bradycardic activities of Oleandrin.
Bucindolol Bucindolol may increase the bradycardic activities of Oleandrin.
Esatenolol Esatenolol may increase the bradycardic activities of Oleandrin.
Cloranolol Cloranolol may increase the bradycardic activities of Oleandrin.
Mepindolol Mepindolol may increase the bradycardic activities of Oleandrin.
Epanolol Epanolol may increase the bradycardic activities of Oleandrin.
Tertatolol Tertatolol may increase the bradycardic activities of Oleandrin.
Landiolol Landiolol may increase the bradycardic activities of Oleandrin.
Erythromycin The serum concentration of Oleandrin can be increased when it is combined with Erythromycin.
Azithromycin The serum concentration of Oleandrin can be increased when it is combined with Azithromycin.
Sirolimus The serum concentration of Oleandrin can be increased when it is combined with Sirolimus.
Dirithromycin The serum concentration of Oleandrin can be increased when it is combined with Dirithromycin.
Telithromycin The serum concentration of Oleandrin can be increased when it is combined with Telithromycin.
Candicidin The serum concentration of Oleandrin can be increased when it is combined with Candicidin.
Clarithromycin The serum concentration of Oleandrin can be increased when it is combined with Clarithromycin.
Josamycin The serum concentration of Oleandrin can be increased when it is combined with Josamycin.
Everolimus The serum concentration of Oleandrin can be increased when it is combined with Everolimus.
Epothilone D The serum concentration of Oleandrin can be increased when it is combined with Epothilone D.
Patupilone The serum concentration of Oleandrin can be increased when it is combined with Patupilone.
6-Deoxyerythronolide B The serum concentration of Oleandrin can be increased when it is combined with 6-Deoxyerythronolide B.
Ixabepilone The serum concentration of Oleandrin can be increased when it is combined with Ixabepilone.
KOS-1584 The serum concentration of Oleandrin can be increased when it is combined with KOS-1584.
Ridaforolimus The serum concentration of Oleandrin can be increased when it is combined with Ridaforolimus.
Temsirolimus The serum concentration of Oleandrin can be increased when it is combined with Temsirolimus.
AVE9633 The serum concentration of Oleandrin can be increased when it is combined with AVE9633.
Coltuximab ravtansine The serum concentration of Oleandrin can be increased when it is combined with Coltuximab ravtansine.
Cethromycin The serum concentration of Oleandrin can be increased when it is combined with Cethromycin.
Mitemcinal The serum concentration of Oleandrin can be increased when it is combined with Mitemcinal.
Brefeldin A The serum concentration of Oleandrin can be increased when it is combined with Brefeldin A.
Solithromycin The serum concentration of Oleandrin can be increased when it is combined with Solithromycin.
Kitasamycin The serum concentration of Oleandrin can be increased when it is combined with Kitasamycin.
Carbomycin The serum concentration of Oleandrin can be increased when it is combined with Carbomycin.
Doramectin The serum concentration of Oleandrin can be increased when it is combined with Doramectin.
Eprinomectin The serum concentration of Oleandrin can be increased when it is combined with Eprinomectin.
Oleandomycin The serum concentration of Oleandrin can be increased when it is combined with Oleandomycin.
Selamectin The serum concentration of Oleandrin can be increased when it is combined with Selamectin.
Tildipirosin The serum concentration of Oleandrin can be increased when it is combined with Tildipirosin.
Tilmicosin The serum concentration of Oleandrin can be increased when it is combined with Tilmicosin.
Tylosin The serum concentration of Oleandrin can be increased when it is combined with Tylosin.

Target Protein

Sodium/potassium-transporting ATPase subunit alpha-1 ATP1A1
Sodium/potassium-transporting ATPase subunit alpha-2 ATP1A2
Sodium/potassium-transporting ATPase subunit alpha-3 ATP1A3
Sodium/potassium-transporting ATPase subunit beta-1 ATP1B1
Sodium/potassium-transporting ATPase subunit beta-2 ATP1B2
Sodium/potassium-transporting ATPase subunit beta-3 ATP1B3
Matrix metalloproteinase-9 MMP9
72 kDa type IV collagenase MMP2
Apoptosis regulator Bcl-2 BCL2
Beta-nerve growth factor NGF
Caspase-3 CASP3
Caspase-8 CASP8
Ephrin type-B receptor 2 EPHB2
Interleukin-8 CXCL8
Pro-epidermal growth factor EGF
Serine/threonine-protein kinase mTOR MTOR
Nuclear factor NF-kappa-B complex NFKB2

Referensi & Sumber

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