Peringatan Keamanan

There is no information available regarding the LD₅₀ and overdose of secnidazole.

Secnidazole

DB12834

small molecule approved

Deskripsi

Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including DB00916 and DB00911, but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive and Gram-negative bacteria as well as protozoa.^A27210 Once it enters bacteria and parasites, secnidazole is activated by bacterial or parasitic enzymes to form a radical anion, thereby damaging and killing the target pathogen.^A245503

Secnidazole has been available in many other countries in Europe, Asia, South America, and Africa for decades.A245503, A245508 In September 2017, FDA approved secnidazole under the market name Solosec for the treatment of trichomoniasis and bacterial vaginosis.^L39524

Struktur Molekul 2D

Berat 185.183

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) The plasma elimination half-life for secnidazole is approximately 17 hours.[L39524]

Volume Distribusi The apparent volume of distribution of secnidazole is approximately 42 L.[L39524]

Klirens (Clearance) The total body clearance of secnidazole is approximately 25 mL/min. The renal clearance is approximately 3.9 mL/min.[L39524]

Absorpsi

Secnidazole is rapidly and completely absorbed after oral administration.^A27210 Following administration of a single oral dose of 2 g in healthy adult female subjects, the mean (SD) C_max was 45.4 (7.64) mcg/mL and mean (SD) systemic exposure (AUC_0-inf) was 1331.6 (230.16) mcg x hr/mL. T_max ranged from three to four hours. Food has negligible effects on drug absorption and systemic exposure.^L39524

Metabolisme

The metabolism of secnidazole has not been fully characterized. According to in vitro studies, secnidazole is metabolized by hepatic CYP450 enzymes, with less than or equal to 1% of the parent drug converted to metabolites.^L39524 Secnidazole was found to be metabolized by CYP3A4 and CYP3A5 but to a limited extent.^A245498 Secnidazole most likely undergoes oxidation. A hydroxymethyl metabolite and glucuronide conjugates of secnidazole have been detected in urine.^A27210

Rute Eliminasi

Following oral administration of a 2 g oral dose of secnidazole, approximately 15% of the drug was excreted as unchanged secnidazole in the urine.^L39524

Interaksi Makanan

2 Data

1. Avoid alcohol. Avoid consumption of alcoholic beverages and preparations containing ethanol or propylene glycol during treatment with secnidazole and for at least two days after completing therapy.
2. Take with or without food. Sprinkle onto applesauce, yogurt, or pudding and ingest without crushing the granules.

Interaksi Obat

0 Data

Tidak ada data.

Referensi & Sumber

Artikel (PubMed)

PMID: 8706597
Gillis JC, Wiseman LR: Secnidazole. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic use in the management of protozoal infections and bacterial vaginosis. Drugs. 1996 Apr;51(4):621-38.
PMID: 32776491
Pentikis HS, Adetoro N, Kaufman G: In vitro metabolic profile and drug-drug interaction assessment of secnidazole, a high-dose 5-nitroimidazole antibiotic for the treatment of bacterial vaginosis. Pharmacol Res Perspect. 2020 Aug;8(4):e00634. doi: 10.1002/prp2.634.
PMID: 31643547
Authors unspecified: Secnidazole .
PMID: 29327947
Nyirjesy P, Schwebke JR: Secnidazole: next-generation antimicrobial agent for bacterial vaginosis treatment. Future Microbiol. 2018 Apr;13:507-524. doi: 10.2217/fmb-2017-0270. Epub 2018 Jan 12.

Link

Contoh Produk & Brand

Produk: 3 • International brands: 0

Produk

Solosec

Granule • 2 g/4.8g • Oral • US • Approved
Solosec

Granule • 2 g/4.8g • Oral • US • Approved
Solosec

Granule • 2 g/4.8g • Oral • US • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.