Polmacoxib

DB12399

small molecule investigational

Deskripsi

Polmacoxib has been used in trials studying the treatment of Osteoarthritis, Osteoarthritis, Hip, Osteoarthritis, Knee, Localized Primary Osteoarthritis of Hip, and Localized Primary Osteoarthritis of Knee.

Struktur Molekul 2D

Berat 361.39
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

683 Data
Aliskiren The risk or severity of renal failure and hypertension can be increased when Polmacoxib is combined with Aliskiren.
Deferasirox The risk or severity of gastrointestinal bleeding and peptic ulcer can be increased when Polmacoxib is combined with Deferasirox.
Desmopressin The risk or severity of hypertension, hyponatremia, and water intoxication can be increased when Polmacoxib is combined with Desmopressin.
Digoxin Polmacoxib may decrease the excretion rate of Digoxin which could result in a higher serum level.
Metildigoxin Polmacoxib may decrease the excretion rate of Metildigoxin which could result in a higher serum level.
Acetyldigoxin Polmacoxib may decrease the excretion rate of Acetyldigoxin which could result in a higher serum level.
Drospirenone The risk or severity of hyperkalemia can be increased when Polmacoxib is combined with Drospirenone.
Haloperidol The therapeutic efficacy of Haloperidol can be increased when used in combination with Polmacoxib.
Hydralazine Polmacoxib may decrease the antihypertensive activities of Hydralazine.
Lithium citrate Polmacoxib may decrease the excretion rate of Lithium citrate which could result in a higher serum level.
Lithium carbonate Polmacoxib may decrease the excretion rate of Lithium carbonate which could result in a higher serum level.
Lithium hydroxide Polmacoxib may decrease the excretion rate of Lithium hydroxide which could result in a higher serum level.
Methotrexate The serum concentration of Methotrexate can be increased when it is combined with Polmacoxib.
Pemetrexed Polmacoxib may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Pralatrexate Polmacoxib may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Probenecid Probenecid may decrease the excretion rate of Polmacoxib which could result in a higher serum level.
Tenofovir disoproxil Polmacoxib may decrease the excretion rate of Tenofovir disoproxil which could result in a higher serum level.
Tenofovir alafenamide Polmacoxib may decrease the excretion rate of Tenofovir alafenamide which could result in a higher serum level.
Tenofovir Polmacoxib may decrease the excretion rate of Tenofovir which could result in a higher serum level.
Treprostinil The risk or severity of bleeding can be increased when Treprostinil is combined with Polmacoxib.
Vancomycin Polmacoxib may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Alendronic acid The risk or severity of adverse effects can be increased when Polmacoxib is combined with Alendronic acid.
Acetylsalicylic acid The risk or severity of adverse effects can be increased when Acetylsalicylic acid is combined with Polmacoxib.
Lepirudin The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Lepirudin.
Bivalirudin The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Bivalirudin.
Alteplase The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Alteplase.
Urokinase The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Urokinase.
Reteplase The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Reteplase.
Anistreplase The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Anistreplase.
Tenecteplase The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Tenecteplase.
Abciximab The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Abciximab.
Drotrecogin alfa The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Drotrecogin alfa.
Streptokinase The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Streptokinase.
Dicoumarol The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Dicoumarol.
Argatroban The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Argatroban.
Ardeparin The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Ardeparin.
Phenindione The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Phenindione.
Fondaparinux The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Fondaparinux.
Warfarin The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Warfarin.
Pentosan polysulfate The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Pentosan polysulfate.
Phenprocoumon The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Phenprocoumon.
Dipyridamole The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Dipyridamole.
Heparin The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Heparin.
Enoxaparin The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Enoxaparin.
Epoprostenol The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Epoprostenol.
Acenocoumarol The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Acenocoumarol.
4-hydroxycoumarin The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with 4-hydroxycoumarin.
Coumarin The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Coumarin.
Ximelagatran The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Ximelagatran.
Desmoteplase The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Desmoteplase.
Defibrotide The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Defibrotide.
Ancrod The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Ancrod.
Beraprost The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Beraprost.
Prasugrel The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Prasugrel.
Rivaroxaban The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Rivaroxaban.
Sulodexide The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Sulodexide.
Semuloparin The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Semuloparin.
Idraparinux The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Idraparinux.
Cangrelor The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Cangrelor.
Astaxanthin The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Astaxanthin.
Apixaban The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Apixaban.
Otamixaban The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Otamixaban.
Amediplase The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Amediplase.
Dabigatran etexilate The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Dabigatran etexilate.
Danaparoid The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Danaparoid.
Dalteparin The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Dalteparin.
Tinzaparin The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Tinzaparin.
(R)-warfarin The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with (R)-warfarin.
Ethyl biscoumacetate The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Ethyl biscoumacetate.
Nadroparin The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Nadroparin.
Triflusal The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Triflusal.
Ticagrelor The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Ticagrelor.
Ditazole The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Ditazole.
Vorapaxar The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Vorapaxar.
Edoxaban The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Edoxaban.
Sodium citrate The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Sodium citrate.
Dextran The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Dextran.
Bemiparin The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Bemiparin.
Parnaparin The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Parnaparin.
Desirudin The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Desirudin.
Antithrombin Alfa The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Antithrombin Alfa.
Protein C The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Protein C.
Antithrombin III human The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Antithrombin III human.
Letaxaban The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Letaxaban.
Darexaban The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Darexaban.
Nafamostat The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Nafamostat.
Monteplase The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Monteplase.
Gabexate The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Gabexate.
Fluindione The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Fluindione.
Protein S human The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Protein S human.
Brinase The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Brinase.
Clorindione The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Clorindione.
Diphenadione The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Diphenadione.
Tioclomarol The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Tioclomarol.
Melagatran The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Melagatran.
Saruplase The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Saruplase.
(S)-Warfarin The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with (S)-Warfarin.
Tocopherylquinone The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Tocopherylquinone.
Dabigatran The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Dabigatran.
Troxerutin The risk or severity of bleeding and hemorrhage can be increased when Polmacoxib is combined with Troxerutin.

Target Protein

Prostaglandin G/H synthase 2 PTGS2
Carbonic anhydrase 1 CA1
Carbonic anhydrase 2 CA2

Referensi & Sumber

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Sekuens Gen/Protein (FASTA)

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