radotinib shares the recently reported cardiovascular toxicity of nilotinib. Electrocardiographic abnormalities were recorded in 20% of all patients and
some of them developed severe or even life-threatening coronary artery disease, QT prolongation, changes in left ventricular ejection fraction.
Radotinib is under investigation for the treatment of Leukemia, Myelogenous, Chronic, BCR-ABL Positive.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Acetaminophen | The serum concentration of Acetaminophen can be increased when it is combined with Radotinib. |
| Propacetamol | The serum concentration of Propacetamol can be increased when it is combined with Radotinib. |
| Salmon calcitonin | The therapeutic efficacy of Salmon calcitonin can be decreased when used in combination with Radotinib. |
| Thyrotropin alfa | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Radotinib. |
| Follitropin | The therapeutic efficacy of Follitropin can be decreased when used in combination with Radotinib. |
| Liothyronine | The therapeutic efficacy of Liothyronine can be decreased when used in combination with Radotinib. |
| Carbimazole | The therapeutic efficacy of Carbimazole can be decreased when used in combination with Radotinib. |
| Levothyroxine | The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Radotinib. |
| Propylthiouracil | The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Radotinib. |
| Methimazole | The therapeutic efficacy of Methimazole can be decreased when used in combination with Radotinib. |
| Liotrix | The therapeutic efficacy of Liotrix can be decreased when used in combination with Radotinib. |
| 3,5-Diiodotyrosine | The therapeutic efficacy of 3,5-Diiodotyrosine can be decreased when used in combination with Radotinib. |
| Tiratricol | The therapeutic efficacy of Tiratricol can be decreased when used in combination with Radotinib. |
| Parathyroid hormone | The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Radotinib. |
| Teriparatide | The therapeutic efficacy of Teriparatide can be decreased when used in combination with Radotinib. |
| Potassium Iodide | The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Radotinib. |
| Dibromotyrosine | The therapeutic efficacy of Dibromotyrosine can be decreased when used in combination with Radotinib. |
| Thyroid, porcine | The therapeutic efficacy of Thyroid, porcine can be decreased when used in combination with Radotinib. |
| Potassium perchlorate | The therapeutic efficacy of Potassium perchlorate can be decreased when used in combination with Radotinib. |
| Protirelin | The therapeutic efficacy of Protirelin can be decreased when used in combination with Radotinib. |
| 3,5-diiodothyropropionic acid | The therapeutic efficacy of 3,5-diiodothyropropionic acid can be decreased when used in combination with Radotinib. |
| Methylthiouracil | The therapeutic efficacy of Methylthiouracil can be decreased when used in combination with Radotinib. |
| Elcatonin | The therapeutic efficacy of Elcatonin can be decreased when used in combination with Radotinib. |
| Benzylthiouracil | The therapeutic efficacy of Benzylthiouracil can be decreased when used in combination with Radotinib. |
| Thyrotropin | The therapeutic efficacy of Thyrotropin can be decreased when used in combination with Radotinib. |
| Voriconazole | The serum concentration of Radotinib can be increased when it is combined with Voriconazole. |
| Palopegteriparatide | The therapeutic efficacy of Palopegteriparatide can be decreased when used in combination with Radotinib. |