Darexaban

DB12289

small molecule investigational

Deskripsi

Darexaban has been used in trials studying the prevention and basic science of Japanese, Caucasian, Thromboembolism, Pharmacodynamics, and Pharmacokinetics, among others.

Struktur Molekul 2D

Berat 474.561
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.

Interaksi Obat

640 Data
Apixaban Apixaban may increase the anticoagulant activities of Darexaban.
Dabigatran etexilate Dabigatran etexilate may increase the anticoagulant activities of Darexaban.
Dasatinib The risk or severity of bleeding and hemorrhage can be increased when Dasatinib is combined with Darexaban.
Deferasirox The risk or severity of gastrointestinal bleeding can be increased when Darexaban is combined with Deferasirox.
Ursodeoxycholic acid The risk or severity of bleeding and bruising can be increased when Darexaban is combined with Ursodeoxycholic acid.
Glycochenodeoxycholic Acid The risk or severity of bleeding and bruising can be increased when Darexaban is combined with Glycochenodeoxycholic Acid.
Cholic Acid The risk or severity of bleeding and bruising can be increased when Darexaban is combined with Cholic Acid.
Glycocholic acid The risk or severity of bleeding and bruising can be increased when Darexaban is combined with Glycocholic acid.
Deoxycholic acid The risk or severity of bleeding and bruising can be increased when Darexaban is combined with Deoxycholic acid.
Taurocholic acid The risk or severity of bleeding and bruising can be increased when Darexaban is combined with Taurocholic acid.
Obeticholic acid The risk or severity of bleeding and bruising can be increased when Darexaban is combined with Obeticholic acid.
Chenodeoxycholic acid The risk or severity of bleeding and bruising can be increased when Darexaban is combined with Chenodeoxycholic acid.
Taurochenodeoxycholic acid The risk or severity of bleeding and bruising can be increased when Darexaban is combined with Taurochenodeoxycholic acid.
Tauroursodeoxycholic acid The risk or severity of bleeding and bruising can be increased when Darexaban is combined with Tauroursodeoxycholic acid.
Bamet-UD2 The risk or severity of bleeding and bruising can be increased when Darexaban is combined with Bamet-UD2.
Dehydrocholic acid The risk or severity of bleeding and bruising can be increased when Darexaban is combined with Dehydrocholic acid.
Hyodeoxycholic Acid The risk or severity of bleeding and bruising can be increased when Darexaban is combined with Hyodeoxycholic Acid.
Edoxaban The risk or severity of bleeding can be increased when Edoxaban is combined with Darexaban.
Ibrutinib The risk or severity of bleeding and hemorrhage can be increased when Ibrutinib is combined with Darexaban.
Obinutuzumab The risk or severity of bleeding and hemorrhage can be increased when Darexaban is combined with Obinutuzumab.
Rivaroxaban Darexaban may increase the anticoagulant activities of Rivaroxaban.
Sugammadex The risk or severity of bleeding and hemorrhage can be increased when Darexaban is combined with Sugammadex.
Tibolone Tibolone may increase the anticoagulant activities of Darexaban.
Tipranavir The risk or severity of bleeding and hemorrhage can be increased when Tipranavir is combined with Darexaban.
Urokinase Urokinase may increase the anticoagulant activities of Darexaban.
Vitamin E Vitamin E may increase the anticoagulant activities of Darexaban.
Vorapaxar The risk or severity of bleeding and hemorrhage can be increased when Vorapaxar is combined with Darexaban.
Ginkgo biloba Ginkgo biloba may increase the anticoagulant activities of Darexaban.
Ifosfamide The risk or severity of bleeding can be increased when Ifosfamide is combined with Darexaban.
Quinine The therapeutic efficacy of Darexaban can be increased when used in combination with Quinine.
Quinidine The therapeutic efficacy of Darexaban can be increased when used in combination with Quinidine.
Tamoxifen The risk or severity of bleeding can be increased when Tamoxifen is combined with Darexaban.
Toremifene The risk or severity of bleeding can be increased when Toremifene is combined with Darexaban.
Pentoxifylline The therapeutic efficacy of Darexaban can be increased when used in combination with Pentoxifylline.
Pentosan polysulfate Pentosan polysulfate may increase the anticoagulant activities of Darexaban.
Levocarnitine The therapeutic efficacy of Darexaban can be increased when used in combination with Levocarnitine.
Diethylstilbestrol Diethylstilbestrol may decrease the anticoagulant activities of Darexaban.
Chlorotrianisene Chlorotrianisene may decrease the anticoagulant activities of Darexaban.
Conjugated estrogens Conjugated estrogens may decrease the anticoagulant activities of Darexaban.
Mestranol The risk or severity of adverse effects can be increased when Mestranol is combined with Darexaban.
Estrone sulfate Estrone sulfate may decrease the anticoagulant activities of Darexaban.
Quinestrol Quinestrol may decrease the anticoagulant activities of Darexaban.
Hexestrol Hexestrol may decrease the anticoagulant activities of Darexaban.
Synthetic Conjugated Estrogens, A Synthetic Conjugated Estrogens, A may decrease the anticoagulant activities of Darexaban.
Synthetic Conjugated Estrogens, B Synthetic Conjugated Estrogens, B may decrease the anticoagulant activities of Darexaban.
Polyestradiol phosphate Polyestradiol phosphate may decrease the anticoagulant activities of Darexaban.
Esterified estrogens Esterified estrogens may decrease the anticoagulant activities of Darexaban.
Zeranol Zeranol may decrease the anticoagulant activities of Darexaban.
Equol Equol may decrease the anticoagulant activities of Darexaban.
Methallenestril Methallenestril may decrease the anticoagulant activities of Darexaban.
Epimestrol Epimestrol may decrease the anticoagulant activities of Darexaban.
Moxestrol Moxestrol may decrease the anticoagulant activities of Darexaban.
Estradiol acetate Estradiol acetate may decrease the anticoagulant activities of Darexaban.
Estradiol benzoate Estradiol benzoate may decrease the anticoagulant activities of Darexaban.
Estradiol cypionate Estradiol cypionate may decrease the anticoagulant activities of Darexaban.
Estradiol valerate Estradiol valerate may decrease the anticoagulant activities of Darexaban.
Biochanin A Biochanin A may decrease the anticoagulant activities of Darexaban.
Formononetin Formononetin may decrease the anticoagulant activities of Darexaban.
Estriol Estriol may decrease the anticoagulant activities of Darexaban.
Limaprost The risk or severity of adverse effects can be increased when Limaprost is combined with Darexaban.
Icosapent The risk or severity of bleeding and hemorrhage can be increased when Icosapent is combined with Darexaban.
Mesalazine The risk or severity of bleeding can be increased when Mesalazine is combined with Darexaban.
Indomethacin The risk or severity of bleeding and hemorrhage can be increased when Indomethacin is combined with Darexaban.
Nabumetone The risk or severity of bleeding and hemorrhage can be increased when Nabumetone is combined with Darexaban.
Ketorolac The risk or severity of bleeding and hemorrhage can be increased when Ketorolac is combined with Darexaban.
Tenoxicam The risk or severity of bleeding and hemorrhage can be increased when Tenoxicam is combined with Darexaban.
Celecoxib The risk or severity of bleeding and hemorrhage can be increased when Celecoxib is combined with Darexaban.
Tolmetin The risk or severity of bleeding and hemorrhage can be increased when Tolmetin is combined with Darexaban.
Rofecoxib The risk or severity of bleeding and hemorrhage can be increased when Rofecoxib is combined with Darexaban.
Piroxicam The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Darexaban.
Fenoprofen The risk or severity of bleeding and hemorrhage can be increased when Fenoprofen is combined with Darexaban.
Valdecoxib The risk or severity of bleeding and hemorrhage can be increased when Valdecoxib is combined with Darexaban.
Diclofenac The risk or severity of bleeding and hemorrhage can be increased when Diclofenac is combined with Darexaban.
Sulindac The risk or severity of bleeding and hemorrhage can be increased when Sulindac is combined with Darexaban.
Flurbiprofen The risk or severity of bleeding and hemorrhage can be increased when Flurbiprofen is combined with Darexaban.
Etodolac The risk or severity of bleeding and hemorrhage can be increased when Etodolac is combined with Darexaban.
Mefenamic acid The risk or severity of bleeding and hemorrhage can be increased when Mefenamic acid is combined with Darexaban.
Naproxen The risk or severity of bleeding and hemorrhage can be increased when Naproxen is combined with Darexaban.
Sulfasalazine The risk or severity of bleeding and hemorrhage can be increased when Sulfasalazine is combined with Darexaban.
Phenylbutazone The risk or severity of bleeding and hemorrhage can be increased when Phenylbutazone is combined with Darexaban.
Meloxicam The risk or severity of bleeding and hemorrhage can be increased when Meloxicam is combined with Darexaban.
Carprofen The risk or severity of bleeding and hemorrhage can be increased when Carprofen is combined with Darexaban.
Diflunisal The risk or severity of bleeding and hemorrhage can be increased when Diflunisal is combined with Darexaban.
Salicylic acid The risk or severity of bleeding and hemorrhage can be increased when Salicylic acid is combined with Darexaban.
Meclofenamic acid The risk or severity of bleeding and hemorrhage can be increased when Meclofenamic acid is combined with Darexaban.
Oxaprozin The risk or severity of bleeding and hemorrhage can be increased when Oxaprozin is combined with Darexaban.
Ketoprofen The risk or severity of bleeding and hemorrhage can be increased when Ketoprofen is combined with Darexaban.
Balsalazide The risk or severity of bleeding and hemorrhage can be increased when Balsalazide is combined with Darexaban.
Olsalazine The risk or severity of bleeding can be increased when Olsalazine is combined with Darexaban.
Lumiracoxib The risk or severity of bleeding and hemorrhage can be increased when Lumiracoxib is combined with Darexaban.
Magnesium salicylate The risk or severity of bleeding and hemorrhage can be increased when Magnesium salicylate is combined with Darexaban.
Salsalate The risk or severity of bleeding and hemorrhage can be increased when Salsalate is combined with Darexaban.
Choline magnesium trisalicylate The risk or severity of bleeding and hemorrhage can be increased when Choline magnesium trisalicylate is combined with Darexaban.
Antrafenine The risk or severity of bleeding and hemorrhage can be increased when Antrafenine is combined with Darexaban.
Aminophenazone The risk or severity of bleeding and hemorrhage can be increased when Aminophenazone is combined with Darexaban.
Antipyrine The risk or severity of bleeding and hemorrhage can be increased when Antipyrine is combined with Darexaban.
Tiaprofenic acid The risk or severity of bleeding and hemorrhage can be increased when Tiaprofenic acid is combined with Darexaban.
Etoricoxib The risk or severity of bleeding and hemorrhage can be increased when Etoricoxib is combined with Darexaban.
Taxifolin The risk or severity of bleeding and hemorrhage can be increased when Taxifolin is combined with Darexaban.
Oxyphenbutazone The risk or severity of bleeding and hemorrhage can be increased when Oxyphenbutazone is combined with Darexaban.

Target Protein

Coagulation factor X F10

Referensi & Sumber

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