Zalutumumab

DB12202

biotech investigational

Deskripsi

Zalutumumab is a fully human IgG1 monoclonal antibody designed to bind with selectivity to the epidermal growth factor receptor (EGFR). Zalutumumab has been investigated for the treatment of Squamous Cell Cancer and Head and Neck Cancer.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

411 Data
Diethylstilbestrol Diethylstilbestrol may increase the thrombogenic activities of Zalutumumab.
Chlorotrianisene Chlorotrianisene may increase the thrombogenic activities of Zalutumumab.
Conjugated estrogens Conjugated estrogens may increase the thrombogenic activities of Zalutumumab.
Estrone Estrone may increase the thrombogenic activities of Zalutumumab.
Estradiol Estradiol may increase the thrombogenic activities of Zalutumumab.
Dienestrol Dienestrol may increase the thrombogenic activities of Zalutumumab.
Ethinylestradiol Ethinylestradiol may increase the thrombogenic activities of Zalutumumab.
Mestranol Mestranol may increase the thrombogenic activities of Zalutumumab.
Estriol Estriol may increase the thrombogenic activities of Zalutumumab.
Estrone sulfate Estrone sulfate may increase the thrombogenic activities of Zalutumumab.
Quinestrol Quinestrol may increase the thrombogenic activities of Zalutumumab.
Hexestrol Hexestrol may increase the thrombogenic activities of Zalutumumab.
Tibolone Tibolone may increase the thrombogenic activities of Zalutumumab.
Synthetic Conjugated Estrogens, A Synthetic Conjugated Estrogens, A may increase the thrombogenic activities of Zalutumumab.
Synthetic Conjugated Estrogens, B Synthetic Conjugated Estrogens, B may increase the thrombogenic activities of Zalutumumab.
Polyestradiol phosphate Polyestradiol phosphate may increase the thrombogenic activities of Zalutumumab.
Esterified estrogens Esterified estrogens may increase the thrombogenic activities of Zalutumumab.
Zeranol Zeranol may increase the thrombogenic activities of Zalutumumab.
Equol Equol may increase the thrombogenic activities of Zalutumumab.
Promestriene Promestriene may increase the thrombogenic activities of Zalutumumab.
Methallenestril Methallenestril may increase the thrombogenic activities of Zalutumumab.
Epimestrol Epimestrol may increase the thrombogenic activities of Zalutumumab.
Moxestrol Moxestrol may increase the thrombogenic activities of Zalutumumab.
Estradiol acetate Estradiol acetate may increase the thrombogenic activities of Zalutumumab.
Estradiol benzoate Estradiol benzoate may increase the thrombogenic activities of Zalutumumab.
Estradiol cypionate Estradiol cypionate may increase the thrombogenic activities of Zalutumumab.
Estradiol valerate Estradiol valerate may increase the thrombogenic activities of Zalutumumab.
Biochanin A Biochanin A may increase the thrombogenic activities of Zalutumumab.
Formononetin Formononetin may increase the thrombogenic activities of Zalutumumab.
Estetrol Estetrol may increase the thrombogenic activities of Zalutumumab.
Cetuximab The risk or severity of adverse effects can be increased when Cetuximab is combined with Zalutumumab.
Human immunoglobulin G The risk or severity of adverse effects can be increased when Human immunoglobulin G is combined with Zalutumumab.
Omalizumab The risk or severity of adverse effects can be increased when Omalizumab is combined with Zalutumumab.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Zalutumumab.
Abciximab The risk or severity of adverse effects can be increased when Abciximab is combined with Zalutumumab.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Zalutumumab.
Indium In-111 satumomab pendetide The risk or severity of adverse effects can be increased when Indium In-111 satumomab pendetide is combined with Zalutumumab.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with Zalutumumab.
Trastuzumab The risk or severity of adverse effects can be increased when Trastuzumab is combined with Zalutumumab.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Zalutumumab.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Zalutumumab.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Zalutumumab.
Digoxin Immune Fab (Ovine) The risk or severity of adverse effects can be increased when Digoxin Immune Fab (Ovine) is combined with Zalutumumab.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Zalutumumab.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Zalutumumab.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Zalutumumab.
Capromab pendetide The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Zalutumumab.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Zalutumumab.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Zalutumumab.
Natalizumab The risk or severity of adverse effects can be increased when Natalizumab is combined with Zalutumumab.
Palivizumab The risk or severity of adverse effects can be increased when Palivizumab is combined with Zalutumumab.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Zalutumumab.
Bevacizumab The risk or severity of adverse effects can be increased when Bevacizumab is combined with Zalutumumab.
Technetium Tc-99m arcitumomab The risk or severity of adverse effects can be increased when Technetium Tc-99m arcitumomab is combined with Zalutumumab.
Eculizumab The risk or severity of adverse effects can be increased when Eculizumab is combined with Zalutumumab.
Panitumumab The risk or severity of adverse effects can be increased when Panitumumab is combined with Zalutumumab.
Ranibizumab The risk or severity of adverse effects can be increased when Ranibizumab is combined with Zalutumumab.
Galiximab The risk or severity of adverse effects can be increased when Galiximab is combined with Zalutumumab.
Pexelizumab The risk or severity of adverse effects can be increased when Pexelizumab is combined with Zalutumumab.
Afelimomab The risk or severity of adverse effects can be increased when Afelimomab is combined with Zalutumumab.
Epratuzumab The risk or severity of adverse effects can be increased when Epratuzumab is combined with Zalutumumab.
Bectumomab The risk or severity of adverse effects can be increased when Bectumomab is combined with Zalutumumab.
Oregovomab The risk or severity of adverse effects can be increased when Oregovomab is combined with Zalutumumab.
IGN311 The risk or severity of adverse effects can be increased when IGN311 is combined with Zalutumumab.
Adecatumumab The risk or severity of adverse effects can be increased when Adecatumumab is combined with Zalutumumab.
Labetuzumab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Zalutumumab.
Matuzumab The risk or severity of adverse effects can be increased when Matuzumab is combined with Zalutumumab.
Fontolizumab The risk or severity of adverse effects can be increased when Fontolizumab is combined with Zalutumumab.
Bavituximab The risk or severity of adverse effects can be increased when Bavituximab is combined with Zalutumumab.
CR002 The risk or severity of adverse effects can be increased when CR002 is combined with Zalutumumab.
Rozrolimupab The risk or severity of adverse effects can be increased when Rozrolimupab is combined with Zalutumumab.
Girentuximab The risk or severity of adverse effects can be increased when Girentuximab is combined with Zalutumumab.
Obiltoxaximab The risk or severity of adverse effects can be increased when Obiltoxaximab is combined with Zalutumumab.
XTL-001 The risk or severity of adverse effects can be increased when XTL-001 is combined with Zalutumumab.
NAV 1800 The risk or severity of adverse effects can be increased when NAV 1800 is combined with Zalutumumab.
Briakinumab The risk or severity of adverse effects can be increased when Briakinumab is combined with Zalutumumab.
Otelixizumab The risk or severity of adverse effects can be increased when Otelixizumab is combined with Zalutumumab.
AMG 108 The risk or severity of adverse effects can be increased when AMG 108 is combined with Zalutumumab.
Iratumumab The risk or severity of adverse effects can be increased when Iratumumab is combined with Zalutumumab.
Enokizumab The risk or severity of adverse effects can be increased when Enokizumab is combined with Zalutumumab.
Ramucirumab The risk or severity of adverse effects can be increased when Ramucirumab is combined with Zalutumumab.
Farletuzumab The risk or severity of adverse effects can be increased when Farletuzumab is combined with Zalutumumab.
Veltuzumab The risk or severity of adverse effects can be increased when Veltuzumab is combined with Zalutumumab.
Ustekinumab The risk or severity of adverse effects can be increased when Ustekinumab is combined with Zalutumumab.
Trastuzumab emtansine The risk or severity of adverse effects can be increased when Trastuzumab emtansine is combined with Zalutumumab.
PRO-542 The risk or severity of adverse effects can be increased when PRO-542 is combined with Zalutumumab.
TNX-901 The risk or severity of adverse effects can be increased when TNX-901 is combined with Zalutumumab.
Inotuzumab ozogamicin The risk or severity of adverse effects can be increased when Inotuzumab ozogamicin is combined with Zalutumumab.
RI 624 The risk or severity of adverse effects can be increased when RI 624 is combined with Zalutumumab.
Stamulumab The risk or severity of adverse effects can be increased when MYO-029 is combined with Zalutumumab.
CT-011 The risk or severity of adverse effects can be increased when CT-011 is combined with Zalutumumab.
Leronlimab The risk or severity of adverse effects can be increased when Leronlimab is combined with Zalutumumab.
Glembatumumab vedotin The risk or severity of adverse effects can be increased when Glembatumumab vedotin is combined with Zalutumumab.
Olaratumab The risk or severity of adverse effects can be increased when Olaratumab is combined with Zalutumumab.
IPH 2101 The risk or severity of adverse effects can be increased when IPH 2101 is combined with Zalutumumab.
TB-402 The risk or severity of adverse effects can be increased when TB-402 is combined with Zalutumumab.
Caplacizumab The risk or severity of adverse effects can be increased when Caplacizumab is combined with Zalutumumab.
IMC-1C11 The risk or severity of adverse effects can be increased when IMC-1C11 is combined with Zalutumumab.
Eldelumab The risk or severity of adverse effects can be increased when Eldelumab is combined with Zalutumumab.
Lumiliximab The risk or severity of adverse effects can be increased when Lumiliximab is combined with Zalutumumab.

Target Protein

Epidermal growth factor receptor EGFR

Referensi & Sumber

Artikel (PubMed)
  • PMID: 17602769
    Bastholt L, Specht L, Jensen K, Brun E, Loft A, Petersen J, Kastberg H, Eriksen JG: Phase I/II clinical and pharmacokinetic study evaluating a fully human monoclonal antibody against EGFr (HuMax-EGFr) in patients with advanced squamous cell carcinoma of the head and neck. Radiother Oncol. 2007 Oct;85(1):24-8. Epub 2007 Jun 28.

Contoh Produk & Brand

Produk: 0 • International brands: 3
International Brands
  • HuMax-EGFR
  • HuMax-EGFR-2F8
  • HuMax-EGFR, 2F8

Sekuens Gen/Protein (FASTA)

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