Lorvotuzumab mertansine

DB12089

biotech investigational

Deskripsi

Lorvotuzumab mertansine has been used in trials studying the treatment of SCLC, Leukemia, Ovarian Cancer, Multiple Myeloma, and Merkel Cell Carcinoma, among others.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

690 Data
Eliglustat The metabolism of Eliglustat can be decreased when combined with Lorvotuzumab mertansine.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Lorvotuzumab mertansine.
Alfentanil The serum concentration of Alfentanil can be increased when it is combined with Lorvotuzumab mertansine.
Buspirone The metabolism of Buspirone can be decreased when combined with Lorvotuzumab mertansine.
Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Lorvotuzumab mertansine.
Cisapride The serum concentration of Cisapride can be increased when it is combined with Lorvotuzumab mertansine.
Disopyramide Lorvotuzumab mertansine may increase the QTc-prolonging activities of Disopyramide.
Estazolam The serum concentration of Estazolam can be increased when it is combined with Lorvotuzumab mertansine.
Quinine The serum concentration of Quinine can be increased when it is combined with Lorvotuzumab mertansine.
Quinidine The serum concentration of Quinidine can be increased when it is combined with Lorvotuzumab mertansine.
Repaglinide The serum concentration of Repaglinide can be increased when it is combined with Lorvotuzumab mertansine.
Sirolimus The metabolism of Sirolimus can be decreased when combined with Lorvotuzumab mertansine.
Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Lorvotuzumab mertansine.
Terfenadine The serum concentration of Terfenadine can be increased when it is combined with Lorvotuzumab mertansine.
Triazolam The serum concentration of Triazolam can be increased when it is combined with Lorvotuzumab mertansine.
Cilostazol The metabolism of Cilostazol can be decreased when combined with Lorvotuzumab mertansine.
Colchicine The metabolism of Colchicine can be decreased when combined with Lorvotuzumab mertansine.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Lorvotuzumab mertansine.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Lorvotuzumab mertansine.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Lorvotuzumab mertansine.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Lorvotuzumab mertansine.
Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Lorvotuzumab mertansine.
Zopiclone The metabolism of Zopiclone can be decreased when combined with Lorvotuzumab mertansine.
Lovastatin The metabolism of Lovastatin can be decreased when combined with Lorvotuzumab mertansine.
Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Lorvotuzumab mertansine.
Alprazolam The serum concentration of Alprazolam can be increased when it is combined with Lorvotuzumab mertansine.
Warfarin The serum concentration of Warfarin can be increased when it is combined with Lorvotuzumab mertansine.
Acenocoumarol The serum concentration of Acenocoumarol can be increased when it is combined with Lorvotuzumab mertansine.
(R)-warfarin The serum concentration of (R)-warfarin can be increased when it is combined with Lorvotuzumab mertansine.
R,S-Warfarin alcohol The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Lorvotuzumab mertansine.
S,R-Warfarin alcohol The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Lorvotuzumab mertansine.
(S)-Warfarin The serum concentration of (S)-Warfarin can be increased when it is combined with Lorvotuzumab mertansine.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Lorvotuzumab mertansine.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Lorvotuzumab mertansine.
Telaprevir The serum concentration of Telaprevir can be increased when it is combined with Lorvotuzumab mertansine.
Chlorotrianisene Chlorotrianisene may increase the thrombogenic activities of Lorvotuzumab mertansine.
Estrone Estrone may increase the thrombogenic activities of Lorvotuzumab mertansine.
Dienestrol Dienestrol may increase the thrombogenic activities of Lorvotuzumab mertansine.
Estriol Estriol may increase the thrombogenic activities of Lorvotuzumab mertansine.
Quinestrol Quinestrol may increase the thrombogenic activities of Lorvotuzumab mertansine.
Hexestrol Hexestrol may increase the thrombogenic activities of Lorvotuzumab mertansine.
Tibolone Tibolone may increase the thrombogenic activities of Lorvotuzumab mertansine.
Polyestradiol phosphate Polyestradiol phosphate may increase the thrombogenic activities of Lorvotuzumab mertansine.
Zeranol Zeranol may increase the thrombogenic activities of Lorvotuzumab mertansine.
Equol Equol may increase the thrombogenic activities of Lorvotuzumab mertansine.
Promestriene Promestriene may increase the thrombogenic activities of Lorvotuzumab mertansine.
Methallenestril Methallenestril may increase the thrombogenic activities of Lorvotuzumab mertansine.
Epimestrol Epimestrol may increase the thrombogenic activities of Lorvotuzumab mertansine.
Moxestrol Moxestrol may increase the thrombogenic activities of Lorvotuzumab mertansine.
Biochanin A Biochanin A may increase the thrombogenic activities of Lorvotuzumab mertansine.
Formononetin Formononetin may increase the thrombogenic activities of Lorvotuzumab mertansine.
Diethylstilbestrol Diethylstilbestrol may increase the thrombogenic activities of Lorvotuzumab mertansine.
Conjugated estrogens Conjugated estrogens may increase the thrombogenic activities of Lorvotuzumab mertansine.
Estradiol Estradiol may increase the thrombogenic activities of Lorvotuzumab mertansine.
Ethinylestradiol Ethinylestradiol may increase the thrombogenic activities of Lorvotuzumab mertansine.
Mestranol Mestranol may increase the thrombogenic activities of Lorvotuzumab mertansine.
Estrone sulfate Estrone sulfate may increase the thrombogenic activities of Lorvotuzumab mertansine.
Synthetic Conjugated Estrogens, A Synthetic Conjugated Estrogens, A may increase the thrombogenic activities of Lorvotuzumab mertansine.
Synthetic Conjugated Estrogens, B Synthetic Conjugated Estrogens, B may increase the thrombogenic activities of Lorvotuzumab mertansine.
Esterified estrogens Esterified estrogens may increase the thrombogenic activities of Lorvotuzumab mertansine.
Estradiol acetate Estradiol acetate may increase the thrombogenic activities of Lorvotuzumab mertansine.
Estradiol benzoate Estradiol benzoate may increase the thrombogenic activities of Lorvotuzumab mertansine.
Estradiol cypionate Estradiol cypionate may increase the thrombogenic activities of Lorvotuzumab mertansine.
Estradiol valerate Estradiol valerate may increase the thrombogenic activities of Lorvotuzumab mertansine.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Lorvotuzumab mertansine.
Vintafolide The serum concentration of Vintafolide can be increased when it is combined with Lorvotuzumab mertansine.
Vincamine The serum concentration of Vincamine can be increased when it is combined with Lorvotuzumab mertansine.
Acetyldigitoxin The serum concentration of Acetyldigitoxin can be increased when it is combined with Lorvotuzumab mertansine.
Deslanoside The serum concentration of Deslanoside can be increased when it is combined with Lorvotuzumab mertansine.
Ouabain The serum concentration of Ouabain can be increased when it is combined with Lorvotuzumab mertansine.
Oleandrin The serum concentration of Oleandrin can be increased when it is combined with Lorvotuzumab mertansine.
Cymarin The serum concentration of Cymarin can be increased when it is combined with Lorvotuzumab mertansine.
Proscillaridin The serum concentration of Proscillaridin can be increased when it is combined with Lorvotuzumab mertansine.
Metildigoxin The serum concentration of Metildigoxin can be increased when it is combined with Lorvotuzumab mertansine.
Lanatoside C The serum concentration of Lanatoside C can be increased when it is combined with Lorvotuzumab mertansine.
Gitoformate The serum concentration of Gitoformate can be increased when it is combined with Lorvotuzumab mertansine.
Acetyldigoxin The serum concentration of Acetyldigoxin can be increased when it is combined with Lorvotuzumab mertansine.
Peruvoside The serum concentration of Peruvoside can be increased when it is combined with Lorvotuzumab mertansine.
Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Lorvotuzumab mertansine.
Dicoumarol The serum concentration of Dicoumarol can be increased when it is combined with Lorvotuzumab mertansine.
Phenindione The serum concentration of Phenindione can be increased when it is combined with Lorvotuzumab mertansine.
Coumarin The serum concentration of Coumarin can be increased when it is combined with Lorvotuzumab mertansine.
Tioclomarol The serum concentration of Tioclomarol can be increased when it is combined with Lorvotuzumab mertansine.
Ethyl biscoumacetate The serum concentration of Ethyl biscoumacetate can be increased when it is combined with Lorvotuzumab mertansine.
Diphenadione The serum concentration of Diphenadione can be increased when it is combined with Lorvotuzumab mertansine.
4-hydroxycoumarin The serum concentration of 4-hydroxycoumarin can be increased when it is combined with Lorvotuzumab mertansine.
Fluindione The serum concentration of Fluindione can be increased when it is combined with Lorvotuzumab mertansine.
Clorindione The serum concentration of Clorindione can be increased when it is combined with Lorvotuzumab mertansine.
Oxtriphylline The metabolism of Oxtriphylline can be decreased when combined with Lorvotuzumab mertansine.
Doxofylline The metabolism of Doxofylline can be decreased when combined with Lorvotuzumab mertansine.
Bamifylline The metabolism of Bamifylline can be decreased when combined with Lorvotuzumab mertansine.
Acefylline The metabolism of Acefylline can be decreased when combined with Lorvotuzumab mertansine.
Bufylline The metabolism of Bufylline can be decreased when combined with Lorvotuzumab mertansine.
Fenethylline The metabolism of Fenethylline can be decreased when combined with Lorvotuzumab mertansine.
Proxyphylline The metabolism of Proxyphylline can be decreased when combined with Lorvotuzumab mertansine.
Bromotheophylline The metabolism of Bromotheophylline can be decreased when combined with Lorvotuzumab mertansine.
Pentoxifylline The metabolism of Pentoxifylline can be decreased when combined with Lorvotuzumab mertansine.
8-azaguanine The metabolism of 8-azaguanine can be decreased when combined with Lorvotuzumab mertansine.
7,9-Dimethylguanine The metabolism of 7,9-Dimethylguanine can be decreased when combined with Lorvotuzumab mertansine.
Xanthine The metabolism of Xanthine can be decreased when combined with Lorvotuzumab mertansine.

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