6-O-benzylguanine

DB11919

small molecule investigational

Deskripsi

6-O-benzylguanine has been used in trials studying the treatment of HIV Infection, Adult Gliosarcoma, Adult Glioblastoma, Stage I Adult Hodgkin Lymphoma, and Stage II Adult Hodgkin Lymphoma, among others.

Struktur Molekul 2D

Berat 241.2486
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

709 Data
Deferasirox The serum concentration of 6-O-benzylguanine can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of 6-O-benzylguanine can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of 6-O-benzylguanine can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of 6-O-benzylguanine can be decreased when it is combined with Teriflunomide.
Regadenoson 6-O-benzylguanine may decrease effectiveness of Regadenoson as a diagnostic agent.
Adalimumab The serum concentration of 6-O-benzylguanine can be decreased when it is combined with Adalimumab.
Adenosine The therapeutic efficacy of Adenosine can be decreased when used in combination with 6-O-benzylguanine.
Allopurinol The serum concentration of 6-O-benzylguanine can be increased when it is combined with Allopurinol.
Carbamazepine The serum concentration of 6-O-benzylguanine can be decreased when it is combined with Carbamazepine.
Cimetidine The metabolism of 6-O-benzylguanine can be decreased when combined with Cimetidine.
Disulfiram The serum concentration of 6-O-benzylguanine can be increased when it is combined with Disulfiram.
Febuxostat The serum concentration of the active metabolites of 6-O-benzylguanine can be increased when 6-O-benzylguanine is used in combination with Febuxostat.
Fluvoxamine The metabolism of 6-O-benzylguanine can be decreased when combined with Fluvoxamine.
Formoterol The risk or severity of hypokalemia can be increased when 6-O-benzylguanine is combined with Formoterol.
Indacaterol The risk or severity of adverse effects can be increased when 6-O-benzylguanine is combined with Indacaterol.
Isoniazid The serum concentration of 6-O-benzylguanine can be increased when it is combined with Isoniazid.
Lithium citrate The serum concentration of Lithium citrate can be decreased when it is combined with 6-O-benzylguanine.
Lithium carbonate The serum concentration of Lithium carbonate can be decreased when it is combined with 6-O-benzylguanine.
Lithium hydroxide The serum concentration of Lithium hydroxide can be decreased when it is combined with 6-O-benzylguanine.
Mexiletine The metabolism of 6-O-benzylguanine can be decreased when combined with Mexiletine.
Olodaterol 6-O-benzylguanine may increase the hyperkalemic activities of Olodaterol.
Pancuronium The therapeutic efficacy of Pancuronium can be decreased when used in combination with 6-O-benzylguanine.
Pentoxifylline The serum concentration of 6-O-benzylguanine can be increased when it is combined with Pentoxifylline.
Propafenone The serum concentration of 6-O-benzylguanine can be increased when it is combined with Propafenone.
Quinine The serum concentration of 6-O-benzylguanine can be increased when it is combined with Quinine.
Quinidine The serum concentration of 6-O-benzylguanine can be increased when it is combined with Quinidine.
Riociguat 6-O-benzylguanine may increase the hypotensive activities of Riociguat.
Thiabendazole The metabolism of 6-O-benzylguanine can be decreased when combined with Thiabendazole.
Ticlopidine The metabolism of 6-O-benzylguanine can be decreased when combined with Ticlopidine.
Zafirlukast The serum concentration of Zafirlukast can be decreased when it is combined with 6-O-benzylguanine.
Probenecid The serum concentration of 6-O-benzylguanine can be increased when it is combined with Probenecid.
Abiraterone The serum concentration of 6-O-benzylguanine can be increased when it is combined with Abiraterone.
Isoprenaline The serum concentration of 6-O-benzylguanine can be decreased when it is combined with Isoprenaline.
Cyproterone acetate The metabolism of 6-O-benzylguanine can be increased when combined with Cyproterone acetate.
Amphetamine The risk or severity of adverse effects can be increased when Amphetamine is combined with 6-O-benzylguanine.
Phentermine The risk or severity of adverse effects can be increased when Phentermine is combined with 6-O-benzylguanine.
Midodrine The risk or severity of adverse effects can be increased when Midodrine is combined with 6-O-benzylguanine.
Norepinephrine The risk or severity of adverse effects can be increased when Norepinephrine is combined with 6-O-benzylguanine.
Phenylephrine The risk or severity of adverse effects can be increased when Phenylephrine is combined with 6-O-benzylguanine.
Phenylpropanolamine The risk or severity of adverse effects can be increased when Phenylpropanolamine is combined with 6-O-benzylguanine.
Labetalol The risk or severity of adverse effects can be increased when Labetalol is combined with 6-O-benzylguanine.
Metaraminol The risk or severity of adverse effects can be increased when Metaraminol is combined with 6-O-benzylguanine.
Epinephrine The risk or severity of adverse effects can be increased when Epinephrine is combined with 6-O-benzylguanine.
Methoxamine The risk or severity of adverse effects can be increased when Methoxamine is combined with 6-O-benzylguanine.
Orciprenaline The risk or severity of adverse effects can be increased when Orciprenaline is combined with 6-O-benzylguanine.
Phenmetrazine The risk or severity of adverse effects can be increased when Phenmetrazine is combined with 6-O-benzylguanine.
Dobutamine The risk or severity of adverse effects can be increased when Dobutamine is combined with 6-O-benzylguanine.
Pseudoephedrine The risk or severity of adverse effects can be increased when Pseudoephedrine is combined with 6-O-benzylguanine.
Benzphetamine The risk or severity of adverse effects can be increased when Benzphetamine is combined with 6-O-benzylguanine.
Ritodrine The risk or severity of adverse effects can be increased when Ritodrine is combined with 6-O-benzylguanine.
Terbutaline The risk or severity of adverse effects can be increased when Terbutaline is combined with 6-O-benzylguanine.
Oxymetazoline The risk or severity of adverse effects can be increased when Oxymetazoline is combined with 6-O-benzylguanine.
Diethylpropion The risk or severity of adverse effects can be increased when Diethylpropion is combined with 6-O-benzylguanine.
Dopamine The risk or severity of adverse effects can be increased when Dopamine is combined with 6-O-benzylguanine.
Acebutolol The risk or severity of adverse effects can be increased when Acebutolol is combined with 6-O-benzylguanine.
Lisdexamfetamine The risk or severity of adverse effects can be increased when Lisdexamfetamine is combined with 6-O-benzylguanine.
Fenoterol The risk or severity of adverse effects can be increased when Fenoterol is combined with 6-O-benzylguanine.
Ephedrine The risk or severity of adverse effects can be increased when Ephedrine is combined with 6-O-benzylguanine.
Mephentermine The risk or severity of adverse effects can be increased when Mephentermine is combined with 6-O-benzylguanine.
Procaterol The risk or severity of adverse effects can be increased when Procaterol is combined with 6-O-benzylguanine.
Clenbuterol The risk or severity of adverse effects can be increased when Clenbuterol is combined with 6-O-benzylguanine.
MMDA The risk or severity of adverse effects can be increased when MMDA is combined with 6-O-benzylguanine.
Midomafetamine The risk or severity of adverse effects can be increased when Midomafetamine is combined with 6-O-benzylguanine.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of adverse effects can be increased when 2,5-Dimethoxy-4-ethylamphetamine is combined with 6-O-benzylguanine.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of adverse effects can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with 6-O-benzylguanine.
Tenamfetamine The risk or severity of adverse effects can be increased when Tenamfetamine is combined with 6-O-benzylguanine.
Chlorphentermine The risk or severity of adverse effects can be increased when Chlorphentermine is combined with 6-O-benzylguanine.
Methylenedioxyethamphetamine The risk or severity of adverse effects can be increased when Methylenedioxyethamphetamine is combined with 6-O-benzylguanine.
Dextroamphetamine The risk or severity of adverse effects can be increased when Dextroamphetamine is combined with 6-O-benzylguanine.
Metamfetamine The risk or severity of adverse effects can be increased when Metamfetamine is combined with 6-O-benzylguanine.
Celiprolol The risk or severity of adverse effects can be increased when Celiprolol is combined with 6-O-benzylguanine.
Nylidrin The risk or severity of adverse effects can be increased when Nylidrin is combined with 6-O-benzylguanine.
Tetryzoline The risk or severity of adverse effects can be increased when Tetryzoline is combined with 6-O-benzylguanine.
Tyramine The risk or severity of adverse effects can be increased when Tyramine is combined with 6-O-benzylguanine.
Isoxsuprine The risk or severity of adverse effects can be increased when Isoxsuprine is combined with 6-O-benzylguanine.
Etilefrine The risk or severity of adverse effects can be increased when Etilefrine is combined with 6-O-benzylguanine.
Synephrine The risk or severity of adverse effects can be increased when Synephrine is combined with 6-O-benzylguanine.
Hydroxyamphetamine The risk or severity of adverse effects can be increased when Hydroxyamphetamine is combined with 6-O-benzylguanine.
Iofetamine I-123 The risk or severity of adverse effects can be increased when Iofetamine I-123 is combined with 6-O-benzylguanine.
Racepinephrine The risk or severity of adverse effects can be increased when Racepinephrine is combined with 6-O-benzylguanine.
Ritobegron The risk or severity of adverse effects can be increased when Ritobegron is combined with 6-O-benzylguanine.
Bucindolol The risk or severity of adverse effects can be increased when Bucindolol is combined with 6-O-benzylguanine.
Tramazoline The risk or severity of adverse effects can be increased when Tramazoline is combined with 6-O-benzylguanine.
Mephedrone The risk or severity of adverse effects can be increased when Mephedrone is combined with 6-O-benzylguanine.
Fenozolone The risk or severity of adverse effects can be increased when Fenozolone is combined with 6-O-benzylguanine.
Methoxyphenamine The risk or severity of adverse effects can be increased when Methoxyphenamine is combined with 6-O-benzylguanine.
Tretoquinol The risk or severity of adverse effects can be increased when Tretoquinol is combined with 6-O-benzylguanine.
Gepefrine The risk or severity of adverse effects can be increased when Gepefrine is combined with 6-O-benzylguanine.
Epanolol The risk or severity of adverse effects can be increased when Epanolol is combined with 6-O-benzylguanine.
Prenalterol The risk or severity of adverse effects can be increased when Prenalterol is combined with 6-O-benzylguanine.
Mefenorex The risk or severity of adverse effects can be increased when Mefenorex is combined with 6-O-benzylguanine.
2,5-Dimethoxy-4-ethylthioamphetamine The risk or severity of adverse effects can be increased when 2,5-Dimethoxy-4-ethylthioamphetamine is combined with 6-O-benzylguanine.
Esmolol The risk or severity of adverse effects can be increased when Esmolol is combined with 6-O-benzylguanine.
Betaxolol The risk or severity of adverse effects can be increased when Betaxolol is combined with 6-O-benzylguanine.
Metoprolol The risk or severity of adverse effects can be increased when Metoprolol is combined with 6-O-benzylguanine.
Atenolol The risk or severity of adverse effects can be increased when Atenolol is combined with 6-O-benzylguanine.
Timolol The risk or severity of adverse effects can be increased when Timolol is combined with 6-O-benzylguanine.
Sotalol The risk or severity of adverse effects can be increased when Sotalol is combined with 6-O-benzylguanine.
Propranolol The risk or severity of adverse effects can be increased when Propranolol is combined with 6-O-benzylguanine.
Bisoprolol The risk or severity of adverse effects can be increased when Bisoprolol is combined with 6-O-benzylguanine.

Target Protein

Methylated-DNA--protein-cysteine methyltransferase MGMT

Referensi & Sumber

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Sekuens Gen/Protein (FASTA)

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