Entinostat

DB11841

small molecule investigational

Deskripsi

Entinostat is under investigation for the treatment and other of Volunteers, Breast Cancer, Human Volunteers, and Normal Volunteers. Entinostat has been investigated for the treatment of Non-Small Lung Cancer, Epigenetic Therapy.

Struktur Molekul 2D

Berat 376.416
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

405 Data
Ivabradine Ivabradine may increase the QTc-prolonging activities of Entinostat.
Vorinostat The risk or severity of gastrointestinal bleeding and thrombocytopenia can be increased when Entinostat is combined with Vorinostat.
Dofetilide The risk or severity of QTc prolongation can be increased when Entinostat is combined with Dofetilide.
Citalopram The risk or severity of QTc prolongation can be increased when Entinostat is combined with Citalopram.
Anagrelide The risk or severity of QTc prolongation can be increased when Entinostat is combined with Anagrelide.
Disopyramide The risk or severity of QTc prolongation can be increased when Entinostat is combined with Disopyramide.
Clemastine The risk or severity of QTc prolongation can be increased when Entinostat is combined with Clemastine.
Ibutilide The risk or severity of QTc prolongation can be increased when Entinostat is combined with Ibutilide.
Valproic acid The risk or severity of QTc prolongation can be increased when Entinostat is combined with Valproic acid.
Terfenadine The risk or severity of QTc prolongation can be increased when Entinostat is combined with Terfenadine.
Grepafloxacin The risk or severity of QTc prolongation can be increased when Entinostat is combined with Grepafloxacin.
Quinine The risk or severity of QTc prolongation can be increased when Entinostat is combined with Quinine.
Sotalol The risk or severity of QTc prolongation can be increased when Entinostat is combined with Sotalol.
Erlotinib The risk or severity of QTc prolongation can be increased when Entinostat is combined with Erlotinib.
Toremifene The risk or severity of QTc prolongation can be increased when Entinostat is combined with Toremifene.
Cisapride The risk or severity of QTc prolongation can be increased when Entinostat is combined with Cisapride.
Imatinib The risk or severity of QTc prolongation can be increased when Entinostat is combined with Imatinib.
Astemizole The risk or severity of QTc prolongation can be increased when Entinostat is combined with Astemizole.
Thioridazine The risk or severity of QTc prolongation can be increased when Entinostat is combined with Thioridazine.
Trovafloxacin The risk or severity of QTc prolongation can be increased when Entinostat is combined with Trovafloxacin.
Mifepristone The risk or severity of QTc prolongation can be increased when Entinostat is combined with Mifepristone.
Cocaine The risk or severity of methemoglobinemia can be increased when Entinostat is combined with Cocaine.
Quinidine The risk or severity of QTc prolongation can be increased when Entinostat is combined with Quinidine.
Procainamide The risk or severity of QTc prolongation can be increased when Entinostat is combined with Procainamide.
Pimozide The risk or severity of QTc prolongation can be increased when Entinostat is combined with Pimozide.
Amiodarone The risk or severity of QTc prolongation can be increased when Entinostat is combined with Amiodarone.
Arsenic trioxide The risk or severity of QTc prolongation can be increased when Entinostat is combined with Arsenic trioxide.
Escitalopram The risk or severity of QTc prolongation can be increased when Entinostat is combined with Escitalopram.
Domperidone The risk or severity of QTc prolongation can be increased when Entinostat is combined with Domperidone.
Sparfloxacin The risk or severity of QTc prolongation can be increased when Entinostat is combined with Sparfloxacin.
Halofantrine The risk or severity of QTc prolongation can be increased when Entinostat is combined with Halofantrine.
Bepridil The risk or severity of QTc prolongation can be increased when Entinostat is combined with Bepridil.
Paliperidone The risk or severity of QTc prolongation can be increased when Entinostat is combined with Paliperidone.
Lithium cation The risk or severity of QTc prolongation can be increased when Entinostat is combined with Lithium cation.
Temafloxacin The risk or severity of QTc prolongation can be increased when Entinostat is combined with Temafloxacin.
Zuclopenthixol The risk or severity of QTc prolongation can be increased when Entinostat is combined with Zuclopenthixol.
Tetrabenazine The risk or severity of QTc prolongation can be increased when Entinostat is combined with Tetrabenazine.
Dronedarone The risk or severity of QTc prolongation can be increased when Entinostat is combined with Dronedarone.
Nilotinib The risk or severity of QTc prolongation can be increased when Entinostat is combined with Nilotinib.
Iloperidone The risk or severity of QTc prolongation can be increased when Entinostat is combined with Iloperidone.
Vandetanib The risk or severity of QTc prolongation can be increased when Entinostat is combined with Vandetanib.
Romidepsin The risk or severity of QTc prolongation can be increased when Entinostat is combined with Romidepsin.
Asenapine The risk or severity of QTc prolongation can be increased when Entinostat is combined with Asenapine.
Artemether The risk or severity of QTc prolongation can be increased when Entinostat is combined with Artemether.
Lumefantrine The risk or severity of QTc prolongation can be increased when Entinostat is combined with Lumefantrine.
Vemurafenib The risk or severity of QTc prolongation can be increased when Entinostat is combined with Vemurafenib.
Eliglustat The risk or severity of QTc prolongation can be increased when Entinostat is combined with Eliglustat.
Ribociclib The risk or severity of QTc prolongation can be increased when Ribociclib is combined with Entinostat.
Glasdegib The risk or severity of QTc prolongation can be increased when Entinostat is combined with Glasdegib.
Deutetrabenazine The risk or severity of QTc prolongation can be increased when Entinostat is combined with Deutetrabenazine.
Macimorelin The risk or severity of QTc prolongation can be increased when Entinostat is combined with Macimorelin.
Terodiline The risk or severity of QTc prolongation can be increased when Entinostat is combined with Terodiline.
Leuprolide The risk or severity of QTc prolongation can be increased when Leuprolide is combined with Entinostat.
Goserelin The risk or severity of QTc prolongation can be increased when Goserelin is combined with Entinostat.
Erythromycin The risk or severity of QTc prolongation can be increased when Erythromycin is combined with Entinostat.
Azithromycin The risk or severity of QTc prolongation can be increased when Azithromycin is combined with Entinostat.
Moxifloxacin The risk or severity of QTc prolongation can be increased when Moxifloxacin is combined with Entinostat.
Ranolazine The risk or severity of QTc prolongation can be increased when Ranolazine is combined with Entinostat.
Sulfisoxazole The risk or severity of QTc prolongation can be increased when Sulfisoxazole is combined with Entinostat.
Amitriptyline The risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Entinostat.
Methadone The risk or severity of QTc prolongation can be increased when Methadone is combined with Entinostat.
Diltiazem The risk or severity of QTc prolongation can be increased when Diltiazem is combined with Entinostat.
Clozapine The risk or severity of QTc prolongation can be increased when Entinostat is combined with Clozapine.
Sulpiride The risk or severity of QTc prolongation can be increased when Sulpiride is combined with Entinostat.
Nimodipine The risk or severity of QTc prolongation can be increased when Nimodipine is combined with Entinostat.
Promazine The risk or severity of QTc prolongation can be increased when Promazine is combined with Entinostat.
Prochlorperazine The risk or severity of QTc prolongation can be increased when Prochlorperazine is combined with Entinostat.
Droperidol The risk or severity of QTc prolongation can be increased when Droperidol is combined with Entinostat.
Imipramine The risk or severity of QTc prolongation can be increased when Imipramine is combined with Entinostat.
Chlorpromazine The risk or severity of QTc prolongation can be increased when Chlorpromazine is combined with Entinostat.
Oxaliplatin The risk or severity of QTc prolongation can be increased when Oxaliplatin is combined with Entinostat.
Ciprofloxacin The risk or severity of QTc prolongation can be increased when Ciprofloxacin is combined with Entinostat.
Fluorouracil The risk or severity of QTc prolongation can be increased when Fluorouracil is combined with Entinostat.
Perflutren The risk or severity of QTc prolongation can be increased when Perflutren is combined with Entinostat.
Cinnarizine The risk or severity of QTc prolongation can be increased when Cinnarizine is combined with Entinostat.
Atropine The risk or severity of QTc prolongation can be increased when Atropine is combined with Entinostat.
Chloroquine The risk or severity of QTc prolongation can be increased when Chloroquine is combined with Entinostat.
Efavirenz The risk or severity of QTc prolongation can be increased when Efavirenz is combined with Entinostat.
Adenosine The risk or severity of QTc prolongation can be increased when Adenosine is combined with Entinostat.
Pentamidine The risk or severity of QTc prolongation can be increased when Pentamidine is combined with Entinostat.
Gadobenic acid The risk or severity of QTc prolongation can be increased when Gadobenic acid is combined with Entinostat.
Carbinoxamine The risk or severity of QTc prolongation can be increased when Carbinoxamine is combined with Entinostat.
Dolasetron The risk or severity of QTc prolongation can be increased when Dolasetron is combined with Entinostat.
Roxithromycin The risk or severity of QTc prolongation can be increased when Roxithromycin is combined with Entinostat.
Nalidixic acid The risk or severity of QTc prolongation can be increased when Nalidixic acid is combined with Entinostat.
Cinoxacin The risk or severity of QTc prolongation can be increased when Cinoxacin is combined with Entinostat.
Loperamide The risk or severity of QTc prolongation can be increased when Loperamide is combined with Entinostat.
Granisetron The risk or severity of QTc prolongation can be increased when Granisetron is combined with Entinostat.
Ondansetron The risk or severity of QTc prolongation can be increased when Ondansetron is combined with Entinostat.
Levosimendan The risk or severity of QTc prolongation can be increased when Levosimendan is combined with Entinostat.
Mesoridazine The risk or severity of QTc prolongation can be increased when Mesoridazine is combined with Entinostat.
Desloratadine The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Entinostat.
Telithromycin The risk or severity of QTc prolongation can be increased when Telithromycin is combined with Entinostat.
Lomefloxacin The risk or severity of QTc prolongation can be increased when Lomefloxacin is combined with Entinostat.
Dimenhydrinate The risk or severity of QTc prolongation can be increased when Dimenhydrinate is combined with Entinostat.
Primaquine The risk or severity of QTc prolongation can be increased when Primaquine is combined with Entinostat.
Papaverine The risk or severity of QTc prolongation can be increased when Papaverine is combined with Entinostat.
Chlorpheniramine The risk or severity of QTc prolongation can be increased when Chlorpheniramine is combined with Entinostat.
Nifedipine The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Entinostat.
Levofloxacin The risk or severity of QTc prolongation can be increased when Levofloxacin is combined with Entinostat.

Target Protein

Histone deacetylase HDAC1
Histone deacetylase 1 HDAC1

Referensi & Sumber

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Sekuens Gen/Protein (FASTA)

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