Saracatinib

DB11805

small molecule investigational

Deskripsi

Saracatinib has been investigated for the treatment of Cancer, Osteosarcoma, Ovarian Cancer, Fallopian Tube Cancer, and Primary Peritoneal Cancer.

Struktur Molekul 2D

Berat 542.026
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

240 Data
Eliglustat The metabolism of Eliglustat can be decreased when combined with Saracatinib.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Saracatinib.
Cilostazol The metabolism of Cilostazol can be decreased when combined with Saracatinib.
Colchicine The metabolism of Colchicine can be decreased when combined with Saracatinib.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Saracatinib.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Saracatinib.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Saracatinib.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Saracatinib.
Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Saracatinib.
Zopiclone The metabolism of Zopiclone can be decreased when combined with Saracatinib.
Lovastatin The metabolism of Lovastatin can be decreased when combined with Saracatinib.
Acetaminophen The serum concentration of Acetaminophen can be increased when it is combined with Saracatinib.
Propacetamol The serum concentration of Propacetamol can be increased when it is combined with Saracatinib.
Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Saracatinib.
Alprazolam The metabolism of Alprazolam can be decreased when combined with Saracatinib.
Warfarin The serum concentration of Warfarin can be increased when it is combined with Saracatinib.
Acenocoumarol The serum concentration of Acenocoumarol can be increased when it is combined with Saracatinib.
(R)-warfarin The serum concentration of (R)-warfarin can be increased when it is combined with Saracatinib.
R,S-Warfarin alcohol The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Saracatinib.
S,R-Warfarin alcohol The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Saracatinib.
(S)-Warfarin The serum concentration of (S)-Warfarin can be increased when it is combined with Saracatinib.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Saracatinib.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Saracatinib.
Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Saracatinib.
Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Saracatinib.
Aripiprazole lauroxil The metabolism of Aripiprazole lauroxil can be decreased when combined with Saracatinib.
Azithromycin The metabolism of Azithromycin can be decreased when combined with Saracatinib.
Ziprasidone The metabolism of Ziprasidone can be decreased when combined with Saracatinib.
Chlorpromazine The metabolism of Chlorpromazine can be decreased when combined with Saracatinib.
Albendazole The metabolism of Albendazole can be decreased when combined with Saracatinib.
Cephalexin The metabolism of Cephalexin can be decreased when combined with Saracatinib.
Doxazosin The metabolism of Doxazosin can be decreased when combined with Saracatinib.
Norethisterone The metabolism of Norethisterone can be decreased when combined with Saracatinib.
Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Saracatinib.
Atazanavir The metabolism of Atazanavir can be decreased when combined with Saracatinib.
Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Saracatinib.
Drospirenone The metabolism of Drospirenone can be decreased when combined with Saracatinib.
Allylestrenol The metabolism of Allylestrenol can be decreased when combined with Saracatinib.
Zuclopenthixol The metabolism of Zuclopenthixol can be decreased when combined with Saracatinib.
Roflumilast The serum concentration of Roflumilast can be increased when it is combined with Saracatinib.
Lacosamide The metabolism of Lacosamide can be decreased when combined with Saracatinib.
Linagliptin The metabolism of Linagliptin can be decreased when combined with Saracatinib.
Vorapaxar The metabolism of Vorapaxar can be decreased when combined with Saracatinib.
Suvorexant The metabolism of Suvorexant can be decreased when combined with Saracatinib.
Netupitant The metabolism of Netupitant can be decreased when combined with Saracatinib.
Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Saracatinib.
Nintedanib The metabolism of Nintedanib can be decreased when combined with Saracatinib.
Tenofovir alafenamide The metabolism of Tenofovir alafenamide can be decreased when combined with Saracatinib.
Dihydroergocornine The metabolism of Dihydroergocornine can be decreased when combined with Saracatinib.
Duvelisib The metabolism of Duvelisib can be decreased when combined with Saracatinib.
Gilteritinib The metabolism of Gilteritinib can be decreased when combined with Saracatinib.
9-aminocamptothecin The metabolism of 9-aminocamptothecin can be decreased when combined with Saracatinib.
Methylprednisone The metabolism of Methylprednisone can be decreased when combined with Saracatinib.
Dihydroergocristine The metabolism of Dihydroergocristine can be decreased when combined with Saracatinib.
Dihydroergocryptine The metabolism of Dihydroergocryptine can be decreased when combined with Saracatinib.
Medical Cannabis The metabolism of Medical Cannabis can be decreased when combined with Saracatinib.
Elexacaftor The metabolism of Elexacaftor can be decreased when combined with Saracatinib.
Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Saracatinib.
Fosaprepitant The metabolism of Fosaprepitant can be decreased when combined with Saracatinib.
Lefamulin The metabolism of Lefamulin can be decreased when combined with Saracatinib.
Methysergide The metabolism of Methysergide can be decreased when combined with Saracatinib.
Meperidine The metabolism of Meperidine can be decreased when combined with Saracatinib.
Ebastine The metabolism of Ebastine can be decreased when combined with Saracatinib.
Terfenadine The metabolism of Terfenadine can be decreased when combined with Saracatinib.
Cisapride The metabolism of Cisapride can be decreased when combined with Saracatinib.
Isavuconazole The metabolism of Isavuconazole can be decreased when combined with Saracatinib.
Pretomanid The metabolism of Pretomanid can be decreased when combined with Saracatinib.
Pimavanserin The metabolism of Pimavanserin can be decreased when combined with Saracatinib.
Estetrol The metabolism of Estetrol can be decreased when combined with Saracatinib.
Infigratinib The metabolism of Infigratinib can be decreased when combined with Saracatinib.
Cyclosporine The serum concentration of Cyclosporine can be increased when it is combined with Saracatinib.
Dofetilide The serum concentration of Dofetilide can be increased when it is combined with Saracatinib.
Theophylline The serum concentration of Theophylline can be increased when it is combined with Saracatinib.
Carbamazepine The serum concentration of Carbamazepine can be increased when it is combined with Saracatinib.
Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Saracatinib.
Quinidine The serum concentration of Quinidine can be increased when it is combined with Saracatinib.
Phenprocoumon The serum concentration of Phenprocoumon can be increased when it is combined with Saracatinib.
Busulfan The serum concentration of Busulfan can be increased when it is combined with Saracatinib.
Pimozide The serum concentration of Pimozide can be increased when it is combined with Saracatinib.
Amiodarone The serum concentration of Amiodarone can be increased when it is combined with Saracatinib.
Aminophylline The serum concentration of Aminophylline can be increased when it is combined with Saracatinib.
Paclitaxel The serum concentration of Paclitaxel can be increased when it is combined with Saracatinib.
Dasatinib The serum concentration of Dasatinib can be increased when it is combined with Saracatinib.
Fosphenytoin The serum concentration of Fosphenytoin can be increased when it is combined with Saracatinib.
Digitoxin The serum concentration of Digitoxin can be increased when it is combined with Saracatinib.
Everolimus The serum concentration of Everolimus can be increased when it is combined with Saracatinib.
Dronedarone The serum concentration of Dronedarone can be increased when it is combined with Saracatinib.
Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Saracatinib.
Temsirolimus The serum concentration of Temsirolimus can be increased when it is combined with Saracatinib.
Idelalisib The serum concentration of Idelalisib can be increased when it is combined with Saracatinib.
Ceritinib The serum concentration of Ceritinib can be increased when it is combined with Saracatinib.
Tianeptine The serum concentration of Tianeptine can be increased when it is combined with Saracatinib.
Osimertinib The serum concentration of Osimertinib can be increased when it is combined with Saracatinib.
Ribociclib The serum concentration of Ribociclib can be increased when it is combined with Saracatinib.
Dacomitinib The serum concentration of Dacomitinib can be increased when it is combined with Saracatinib.
Alpelisib The serum concentration of Alpelisib can be increased when it is combined with Saracatinib.
Astemizole The serum concentration of Astemizole can be increased when it is combined with Saracatinib.
Lomitapide The serum concentration of Lomitapide can be increased when it is combined with Saracatinib.
Siponimod The serum concentration of Siponimod can be increased when it is combined with Saracatinib.
Methotrexate The serum concentration of Methotrexate can be increased when it is combined with Saracatinib.

Target Protein

Proto-oncogene tyrosine-protein kinase Src SRC
Tyrosine-protein kinase ABL1 ABL1

Referensi & Sumber

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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