Danoprevir

DB11779

small molecule investigational

Deskripsi

Danoprevir has been used in trials studying the treatment of Hepatitis C, Chronic.

Struktur Molekul 2D

Berat 731.84
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

776 Data
Eliglustat The metabolism of Eliglustat can be decreased when combined with Danoprevir.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Danoprevir.
Cilostazol The metabolism of Cilostazol can be decreased when combined with Danoprevir.
Colchicine The metabolism of Colchicine can be decreased when combined with Danoprevir.
Fentanyl The metabolism of Fentanyl can be decreased when combined with Danoprevir.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Danoprevir.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Danoprevir.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Danoprevir.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Danoprevir.
Alprazolam The metabolism of Alprazolam can be decreased when combined with Danoprevir.
R,S-Warfarin alcohol The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Danoprevir.
S,R-Warfarin alcohol The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Danoprevir.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Danoprevir.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Danoprevir.
Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Danoprevir.
Prucalopride The metabolism of Prucalopride can be decreased when combined with Danoprevir.
Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Danoprevir.
Levamlodipine The serum concentration of Levamlodipine can be increased when it is combined with Danoprevir.
Tramadol The metabolism of Tramadol can be decreased when combined with Danoprevir.
Haloperidol The serum concentration of Haloperidol can be increased when it is combined with Danoprevir.
Trastuzumab emtansine The metabolism of Trastuzumab emtansine can be decreased when combined with Danoprevir.
Almotriptan The metabolism of Almotriptan can be decreased when combined with Danoprevir.
Axitinib The metabolism of Axitinib can be decreased when combined with Danoprevir.
Bedaquiline The metabolism of Bedaquiline can be decreased when combined with Danoprevir.
Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Danoprevir.
Cabazitaxel The metabolism of Cabazitaxel can be decreased when combined with Danoprevir.
Cabozantinib The metabolism of Cabozantinib can be decreased when combined with Danoprevir.
Ceritinib The metabolism of Ceritinib can be decreased when combined with Danoprevir.
Daclatasvir The metabolism of Daclatasvir can be decreased when combined with Danoprevir.
Dasatinib The metabolism of Dasatinib can be decreased when combined with Danoprevir.
Erlotinib The metabolism of Erlotinib can be decreased when combined with Danoprevir.
Fesoterodine The metabolism of Fesoterodine can be decreased when combined with Danoprevir.
Flibanserin The metabolism of Flibanserin can be decreased when combined with Danoprevir.
Guanfacine The metabolism of Guanfacine can be decreased when combined with Danoprevir.
Irinotecan The serum concentration of the active metabolites of Irinotecan can be decreased when Irinotecan is used in combination with Danoprevir.
Lapatinib The metabolism of Lapatinib can be decreased when combined with Danoprevir.
Maraviroc The metabolism of Maraviroc can be decreased when combined with Danoprevir.
Mifepristone The metabolism of Mifepristone can be decreased when combined with Danoprevir.
Nilotinib The metabolism of Nilotinib can be decreased when combined with Danoprevir.
Olaparib The metabolism of Olaparib can be decreased when combined with Danoprevir.
Palbociclib The metabolism of Palbociclib can be decreased when combined with Danoprevir.
Panobinostat The metabolism of Panobinostat can be decreased when combined with Danoprevir.
Pazopanib The metabolism of Pazopanib can be decreased when combined with Danoprevir.
Ponatinib The metabolism of Ponatinib can be decreased when combined with Danoprevir.
Quetiapine The serum concentration of Quetiapine can be increased when it is combined with Danoprevir.
Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Danoprevir.
Saxagliptin The metabolism of Saxagliptin can be decreased when combined with Danoprevir.
Sildenafil The metabolism of Sildenafil can be decreased when combined with Danoprevir.
Trabectedin The metabolism of Trabectedin can be decreased when combined with Danoprevir.
Vilazodone The metabolism of Vilazodone can be decreased when combined with Danoprevir.
Tadalafil The serum concentration of Tadalafil can be increased when it is combined with Danoprevir.
Trazodone The serum concentration of Trazodone can be increased when it is combined with Danoprevir.
Tolterodine The serum concentration of Tolterodine can be increased when it is combined with Danoprevir.
Eplerenone The metabolism of Eplerenone can be decreased when combined with Danoprevir.
Salmeterol The metabolism of Salmeterol can be decreased when combined with Danoprevir.
Riociguat The serum concentration of Riociguat can be increased when it is combined with Danoprevir.
Fluticasone propionate The serum concentration of Fluticasone propionate can be increased when it is combined with Danoprevir.
Barnidipine The metabolism of Barnidipine can be decreased when combined with Danoprevir.
Lumacaftor The serum concentration of Lumacaftor can be increased when it is combined with Danoprevir.
Zopiclone The metabolism of Zopiclone can be decreased when combined with Danoprevir.
Warfarin The metabolism of Warfarin can be decreased when combined with Danoprevir.
Acenocoumarol The metabolism of Acenocoumarol can be decreased when combined with Danoprevir.
(R)-warfarin The metabolism of (R)-warfarin can be decreased when combined with Danoprevir.
(S)-Warfarin The metabolism of (S)-Warfarin can be decreased when combined with Danoprevir.
Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Danoprevir.
Dofetilide The metabolism of Dofetilide can be decreased when combined with Danoprevir.
Azithromycin The metabolism of Azithromycin can be decreased when combined with Danoprevir.
Ziprasidone The metabolism of Ziprasidone can be decreased when combined with Danoprevir.
Theophylline The metabolism of Theophylline can be decreased when combined with Danoprevir.
Chlorpromazine The metabolism of Chlorpromazine can be decreased when combined with Danoprevir.
Albendazole The metabolism of Albendazole can be decreased when combined with Danoprevir.
Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Danoprevir.
Cephalexin The metabolism of Cephalexin can be decreased when combined with Danoprevir.
Norethisterone The metabolism of Norethisterone can be decreased when combined with Danoprevir.
Sirolimus The metabolism of Sirolimus can be decreased when combined with Danoprevir.
Quinidine The metabolism of Quinidine can be decreased when combined with Danoprevir.
Phenprocoumon The metabolism of Phenprocoumon can be decreased when combined with Danoprevir.
Busulfan The metabolism of Busulfan can be decreased when combined with Danoprevir.
Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Danoprevir.
Atazanavir The metabolism of Atazanavir can be decreased when combined with Danoprevir.
Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Danoprevir.
Pimozide The metabolism of Pimozide can be decreased when combined with Danoprevir.
Amiodarone The metabolism of Amiodarone can be decreased when combined with Danoprevir.
Aminophylline The metabolism of Aminophylline can be decreased when combined with Danoprevir.
Paclitaxel The metabolism of Paclitaxel can be decreased when combined with Danoprevir.
Fosphenytoin The metabolism of Fosphenytoin can be decreased when combined with Danoprevir.
Drospirenone The metabolism of Drospirenone can be decreased when combined with Danoprevir.
Digitoxin The metabolism of Digitoxin can be decreased when combined with Danoprevir.
Allylestrenol The metabolism of Allylestrenol can be decreased when combined with Danoprevir.
Everolimus The metabolism of Everolimus can be decreased when combined with Danoprevir.
Zuclopenthixol The metabolism of Zuclopenthixol can be decreased when combined with Danoprevir.
Roflumilast The serum concentration of Roflumilast can be increased when it is combined with Danoprevir.
Milnacipran The metabolism of Milnacipran can be decreased when combined with Danoprevir.
Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Danoprevir.
Lacosamide The metabolism of Lacosamide can be decreased when combined with Danoprevir.
Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Danoprevir.
Linagliptin The metabolism of Linagliptin can be decreased when combined with Danoprevir.
Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Danoprevir.
Vorapaxar The metabolism of Vorapaxar can be decreased when combined with Danoprevir.
Suvorexant The metabolism of Suvorexant can be decreased when combined with Danoprevir.

Target Protein

Gag-Pol polyprotein gag-pol
Genome polyprotein

Referensi & Sumber

Artikel (PubMed)
  • PMID: 18086851
    He Y, King MS, Kempf DJ, Lu L, Lim HB, Krishnan P, Kati W, Middleton T, Molla A: Relative replication capacity and selective advantage profiles of protease inhibitor-resistant hepatitis C virus (HCV) NS3 protease mutants in the HCV genotype 1b replicon system. Antimicrob Agents Chemother. 2008 Mar;52(3):1101-10. Epub 2007 Dec 17.

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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