Bryostatin 1

DB11752

small molecule investigational

Deskripsi

Bryostatin 1 has been investigated for the treatment of HIV Infection and Alzheimer's Disease.

Struktur Molekul 2D

Berat 905.044
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

321 Data
Eliglustat The metabolism of Eliglustat can be decreased when combined with Bryostatin 1.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Bryostatin 1.
Alfentanil The serum concentration of Alfentanil can be increased when it is combined with Bryostatin 1.
Buspirone The metabolism of Buspirone can be decreased when combined with Bryostatin 1.
Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Bryostatin 1.
Cisapride The serum concentration of Cisapride can be increased when it is combined with Bryostatin 1.
Disopyramide Bryostatin 1 may increase the QTc-prolonging activities of Disopyramide.
Estazolam The serum concentration of Estazolam can be increased when it is combined with Bryostatin 1.
Quinine The serum concentration of Quinine can be increased when it is combined with Bryostatin 1.
Quinidine The serum concentration of Quinidine can be increased when it is combined with Bryostatin 1.
Repaglinide The serum concentration of Repaglinide can be increased when it is combined with Bryostatin 1.
Sirolimus The metabolism of Sirolimus can be decreased when combined with Bryostatin 1.
Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Bryostatin 1.
Terfenadine The serum concentration of Terfenadine can be increased when it is combined with Bryostatin 1.
Triazolam The serum concentration of Triazolam can be increased when it is combined with Bryostatin 1.
Cilostazol The metabolism of Cilostazol can be decreased when combined with Bryostatin 1.
Colchicine The metabolism of Colchicine can be decreased when combined with Bryostatin 1.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Bryostatin 1.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Bryostatin 1.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Bryostatin 1.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Bryostatin 1.
Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Bryostatin 1.
Zopiclone The metabolism of Zopiclone can be decreased when combined with Bryostatin 1.
Lovastatin The metabolism of Lovastatin can be decreased when combined with Bryostatin 1.
Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Bryostatin 1.
Alprazolam The serum concentration of Alprazolam can be increased when it is combined with Bryostatin 1.
Warfarin The serum concentration of Warfarin can be increased when it is combined with Bryostatin 1.
Acenocoumarol The serum concentration of Acenocoumarol can be increased when it is combined with Bryostatin 1.
(R)-warfarin The serum concentration of (R)-warfarin can be increased when it is combined with Bryostatin 1.
R,S-Warfarin alcohol The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Bryostatin 1.
S,R-Warfarin alcohol The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Bryostatin 1.
(S)-Warfarin The serum concentration of (S)-Warfarin can be increased when it is combined with Bryostatin 1.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Bryostatin 1.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Bryostatin 1.
Telaprevir The serum concentration of Telaprevir can be increased when it is combined with Bryostatin 1.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Bryostatin 1.
Vintafolide The serum concentration of Vintafolide can be increased when it is combined with Bryostatin 1.
Vincamine The serum concentration of Vincamine can be increased when it is combined with Bryostatin 1.
Acetyldigitoxin The serum concentration of Acetyldigitoxin can be increased when it is combined with Bryostatin 1.
Deslanoside The serum concentration of Deslanoside can be increased when it is combined with Bryostatin 1.
Ouabain The serum concentration of Ouabain can be increased when it is combined with Bryostatin 1.
Oleandrin The serum concentration of Oleandrin can be increased when it is combined with Bryostatin 1.
Cymarin The serum concentration of Cymarin can be increased when it is combined with Bryostatin 1.
Proscillaridin The serum concentration of Proscillaridin can be increased when it is combined with Bryostatin 1.
Metildigoxin The serum concentration of Metildigoxin can be increased when it is combined with Bryostatin 1.
Lanatoside C The serum concentration of Lanatoside C can be increased when it is combined with Bryostatin 1.
Gitoformate The serum concentration of Gitoformate can be increased when it is combined with Bryostatin 1.
Acetyldigoxin The serum concentration of Acetyldigoxin can be increased when it is combined with Bryostatin 1.
Peruvoside The serum concentration of Peruvoside can be increased when it is combined with Bryostatin 1.
Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Bryostatin 1.
Dicoumarol The serum concentration of Dicoumarol can be increased when it is combined with Bryostatin 1.
Phenindione The serum concentration of Phenindione can be increased when it is combined with Bryostatin 1.
Coumarin The serum concentration of Coumarin can be increased when it is combined with Bryostatin 1.
Tioclomarol The serum concentration of Tioclomarol can be increased when it is combined with Bryostatin 1.
Ethyl biscoumacetate The serum concentration of Ethyl biscoumacetate can be increased when it is combined with Bryostatin 1.
Diphenadione The serum concentration of Diphenadione can be increased when it is combined with Bryostatin 1.
4-hydroxycoumarin The serum concentration of 4-hydroxycoumarin can be increased when it is combined with Bryostatin 1.
Fluindione The serum concentration of Fluindione can be increased when it is combined with Bryostatin 1.
Clorindione The serum concentration of Clorindione can be increased when it is combined with Bryostatin 1.
Oxtriphylline The metabolism of Oxtriphylline can be decreased when combined with Bryostatin 1.
Doxofylline The metabolism of Doxofylline can be decreased when combined with Bryostatin 1.
Bamifylline The metabolism of Bamifylline can be decreased when combined with Bryostatin 1.
Acefylline The metabolism of Acefylline can be decreased when combined with Bryostatin 1.
Bufylline The metabolism of Bufylline can be decreased when combined with Bryostatin 1.
Fenethylline The metabolism of Fenethylline can be decreased when combined with Bryostatin 1.
Proxyphylline The metabolism of Proxyphylline can be decreased when combined with Bryostatin 1.
Bromotheophylline The metabolism of Bromotheophylline can be decreased when combined with Bryostatin 1.
Pentoxifylline The metabolism of Pentoxifylline can be decreased when combined with Bryostatin 1.
8-azaguanine The metabolism of 8-azaguanine can be decreased when combined with Bryostatin 1.
7,9-Dimethylguanine The metabolism of 7,9-Dimethylguanine can be decreased when combined with Bryostatin 1.
Xanthine The metabolism of Xanthine can be decreased when combined with Bryostatin 1.
7-Deazaguanine The metabolism of 7-Deazaguanine can be decreased when combined with Bryostatin 1.
Guanine The metabolism of Guanine can be decreased when combined with Bryostatin 1.
9-Methylguanine The metabolism of 9-Methylguanine can be decreased when combined with Bryostatin 1.
Peldesine The metabolism of Peldesine can be decreased when combined with Bryostatin 1.
Hypoxanthine The metabolism of Hypoxanthine can be decreased when combined with Bryostatin 1.
9-Deazaguanine The metabolism of 9-Deazaguanine can be decreased when combined with Bryostatin 1.
Valomaciclovir The metabolism of Valomaciclovir can be decreased when combined with Bryostatin 1.
3-isobutyl-1-methyl-7H-xanthine The metabolism of 3-isobutyl-1-methyl-7H-xanthine can be decreased when combined with Bryostatin 1.
Uric acid The metabolism of Uric acid can be decreased when combined with Bryostatin 1.
6-O-benzylguanine The metabolism of 6-O-benzylguanine can be decreased when combined with Bryostatin 1.
Lisofylline The metabolism of Lisofylline can be decreased when combined with Bryostatin 1.
Lobucavir The metabolism of Lobucavir can be decreased when combined with Bryostatin 1.
Cafedrine The metabolism of Cafedrine can be decreased when combined with Bryostatin 1.
Theodrenaline The metabolism of Theodrenaline can be decreased when combined with Bryostatin 1.
Etamiphylline The metabolism of Etamiphylline can be decreased when combined with Bryostatin 1.
Pentifylline The metabolism of Pentifylline can be decreased when combined with Bryostatin 1.
Furafylline The metabolism of Furafylline can be decreased when combined with Bryostatin 1.
Theobromine The metabolism of Theobromine can be decreased when combined with Bryostatin 1.
Propentofylline The metabolism of Propentofylline can be decreased when combined with Bryostatin 1.
Caffeine The metabolism of Caffeine can be decreased when combined with Bryostatin 1.
8-chlorotheophylline The metabolism of 8-chlorotheophylline can be decreased when combined with Bryostatin 1.
Mercaptopurine The metabolism of Mercaptopurine can be decreased when combined with Bryostatin 1.
PCS-499 The metabolism of PCS-499 can be decreased when combined with Bryostatin 1.
Methylergometrine The serum concentration of Methylergometrine can be increased when it is combined with Bryostatin 1.
Lisuride The serum concentration of Lisuride can be increased when it is combined with Bryostatin 1.
Nicergoline The serum concentration of Nicergoline can be increased when it is combined with Bryostatin 1.
Ergoloid mesylate The serum concentration of Ergoloid mesylate can be increased when it is combined with Bryostatin 1.
Pergolide The serum concentration of Pergolide can be increased when it is combined with Bryostatin 1.
Ergometrine The serum concentration of Ergometrine can be increased when it is combined with Bryostatin 1.

Target Protein

Protein kinase C epsilon type PRKCE
Protein kinase C alpha type PRKCA
Caspase-8 CASP8
Serine/threonine-protein kinase D1 PRKD1
T-lymphocyte activation antigen CD86 CD86
Prostaglandin G/H synthase 2 PTGS2
G1/S-specific cyclin-D1 CCND1
Tumor necrosis factor TNF
Protein unc-13 homolog B Unc13b

Referensi & Sumber

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Sekuens Gen/Protein (FASTA)

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