Depatuxizumab mafodotin

DB11731

biotech investigational

Deskripsi

Depatuxizumab/Denintuzumab mafodotin has been used in trials studying the treatment of Lymphoma, Gliosarcoma, Glioblastoma, Malignant Glioma, Squamous Cell Tumors, and Glioblastoma Multiforme.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

373 Data
Diethylstilbestrol Diethylstilbestrol may increase the thrombogenic activities of Depatuxizumab mafodotin.
Chlorotrianisene Chlorotrianisene may increase the thrombogenic activities of Depatuxizumab mafodotin.
Conjugated estrogens Conjugated estrogens may increase the thrombogenic activities of Depatuxizumab mafodotin.
Estrone Estrone may increase the thrombogenic activities of Depatuxizumab mafodotin.
Estradiol Estradiol may increase the thrombogenic activities of Depatuxizumab mafodotin.
Dienestrol Dienestrol may increase the thrombogenic activities of Depatuxizumab mafodotin.
Ethinylestradiol Ethinylestradiol may increase the thrombogenic activities of Depatuxizumab mafodotin.
Mestranol Mestranol may increase the thrombogenic activities of Depatuxizumab mafodotin.
Estriol Estriol may increase the thrombogenic activities of Depatuxizumab mafodotin.
Estrone sulfate Estrone sulfate may increase the thrombogenic activities of Depatuxizumab mafodotin.
Quinestrol Quinestrol may increase the thrombogenic activities of Depatuxizumab mafodotin.
Hexestrol Hexestrol may increase the thrombogenic activities of Depatuxizumab mafodotin.
Tibolone Tibolone may increase the thrombogenic activities of Depatuxizumab mafodotin.
Synthetic Conjugated Estrogens, A Synthetic Conjugated Estrogens, A may increase the thrombogenic activities of Depatuxizumab mafodotin.
Synthetic Conjugated Estrogens, B Synthetic Conjugated Estrogens, B may increase the thrombogenic activities of Depatuxizumab mafodotin.
Polyestradiol phosphate Polyestradiol phosphate may increase the thrombogenic activities of Depatuxizumab mafodotin.
Esterified estrogens Esterified estrogens may increase the thrombogenic activities of Depatuxizumab mafodotin.
Zeranol Zeranol may increase the thrombogenic activities of Depatuxizumab mafodotin.
Equol Equol may increase the thrombogenic activities of Depatuxizumab mafodotin.
Promestriene Promestriene may increase the thrombogenic activities of Depatuxizumab mafodotin.
Methallenestril Methallenestril may increase the thrombogenic activities of Depatuxizumab mafodotin.
Epimestrol Epimestrol may increase the thrombogenic activities of Depatuxizumab mafodotin.
Moxestrol Moxestrol may increase the thrombogenic activities of Depatuxizumab mafodotin.
Estradiol acetate Estradiol acetate may increase the thrombogenic activities of Depatuxizumab mafodotin.
Estradiol benzoate Estradiol benzoate may increase the thrombogenic activities of Depatuxizumab mafodotin.
Estradiol cypionate Estradiol cypionate may increase the thrombogenic activities of Depatuxizumab mafodotin.
Estradiol valerate Estradiol valerate may increase the thrombogenic activities of Depatuxizumab mafodotin.
Biochanin A Biochanin A may increase the thrombogenic activities of Depatuxizumab mafodotin.
Formononetin Formononetin may increase the thrombogenic activities of Depatuxizumab mafodotin.
Estetrol Estetrol may increase the thrombogenic activities of Depatuxizumab mafodotin.
Cetuximab The risk or severity of adverse effects can be increased when Cetuximab is combined with Depatuxizumab mafodotin.
Human immunoglobulin G The risk or severity of adverse effects can be increased when Human immunoglobulin G is combined with Depatuxizumab mafodotin.
Omalizumab The risk or severity of adverse effects can be increased when Omalizumab is combined with Depatuxizumab mafodotin.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Depatuxizumab mafodotin.
Abciximab The risk or severity of adverse effects can be increased when Abciximab is combined with Depatuxizumab mafodotin.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Depatuxizumab mafodotin.
Indium In-111 satumomab pendetide The risk or severity of adverse effects can be increased when Indium In-111 satumomab pendetide is combined with Depatuxizumab mafodotin.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with Depatuxizumab mafodotin.
Trastuzumab The risk or severity of adverse effects can be increased when Trastuzumab is combined with Depatuxizumab mafodotin.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Depatuxizumab mafodotin.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Depatuxizumab mafodotin.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Depatuxizumab mafodotin.
Digoxin Immune Fab (Ovine) The risk or severity of adverse effects can be increased when Digoxin Immune Fab (Ovine) is combined with Depatuxizumab mafodotin.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Depatuxizumab mafodotin.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Depatuxizumab mafodotin.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Depatuxizumab mafodotin.
Capromab pendetide The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Depatuxizumab mafodotin.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Depatuxizumab mafodotin.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Depatuxizumab mafodotin.
Natalizumab The risk or severity of adverse effects can be increased when Natalizumab is combined with Depatuxizumab mafodotin.
Palivizumab The risk or severity of adverse effects can be increased when Palivizumab is combined with Depatuxizumab mafodotin.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Depatuxizumab mafodotin.
Bevacizumab The risk or severity of adverse effects can be increased when Bevacizumab is combined with Depatuxizumab mafodotin.
Technetium Tc-99m arcitumomab The risk or severity of adverse effects can be increased when Technetium Tc-99m arcitumomab is combined with Depatuxizumab mafodotin.
Eculizumab The risk or severity of adverse effects can be increased when Eculizumab is combined with Depatuxizumab mafodotin.
Panitumumab The risk or severity of adverse effects can be increased when Panitumumab is combined with Depatuxizumab mafodotin.
Ranibizumab The risk or severity of adverse effects can be increased when Ranibizumab is combined with Depatuxizumab mafodotin.
Galiximab The risk or severity of adverse effects can be increased when Galiximab is combined with Depatuxizumab mafodotin.
Pexelizumab The risk or severity of adverse effects can be increased when Pexelizumab is combined with Depatuxizumab mafodotin.
Afelimomab The risk or severity of adverse effects can be increased when Afelimomab is combined with Depatuxizumab mafodotin.
Epratuzumab The risk or severity of adverse effects can be increased when Epratuzumab is combined with Depatuxizumab mafodotin.
Bectumomab The risk or severity of adverse effects can be increased when Bectumomab is combined with Depatuxizumab mafodotin.
Oregovomab The risk or severity of adverse effects can be increased when Oregovomab is combined with Depatuxizumab mafodotin.
IGN311 The risk or severity of adverse effects can be increased when IGN311 is combined with Depatuxizumab mafodotin.
Adecatumumab The risk or severity of adverse effects can be increased when Adecatumumab is combined with Depatuxizumab mafodotin.
Labetuzumab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Depatuxizumab mafodotin.
Matuzumab The risk or severity of adverse effects can be increased when Matuzumab is combined with Depatuxizumab mafodotin.
Fontolizumab The risk or severity of adverse effects can be increased when Fontolizumab is combined with Depatuxizumab mafodotin.
Bavituximab The risk or severity of adverse effects can be increased when Bavituximab is combined with Depatuxizumab mafodotin.
CR002 The risk or severity of adverse effects can be increased when CR002 is combined with Depatuxizumab mafodotin.
Rozrolimupab The risk or severity of adverse effects can be increased when Rozrolimupab is combined with Depatuxizumab mafodotin.
Girentuximab The risk or severity of adverse effects can be increased when Girentuximab is combined with Depatuxizumab mafodotin.
Obiltoxaximab The risk or severity of adverse effects can be increased when Obiltoxaximab is combined with Depatuxizumab mafodotin.
XTL-001 The risk or severity of adverse effects can be increased when XTL-001 is combined with Depatuxizumab mafodotin.
NAV 1800 The risk or severity of adverse effects can be increased when NAV 1800 is combined with Depatuxizumab mafodotin.
Briakinumab The risk or severity of adverse effects can be increased when Briakinumab is combined with Depatuxizumab mafodotin.
Otelixizumab The risk or severity of adverse effects can be increased when Otelixizumab is combined with Depatuxizumab mafodotin.
AMG 108 The risk or severity of adverse effects can be increased when AMG 108 is combined with Depatuxizumab mafodotin.
Iratumumab The risk or severity of adverse effects can be increased when Iratumumab is combined with Depatuxizumab mafodotin.
Enokizumab The risk or severity of adverse effects can be increased when Enokizumab is combined with Depatuxizumab mafodotin.
Ramucirumab The risk or severity of adverse effects can be increased when Ramucirumab is combined with Depatuxizumab mafodotin.
Farletuzumab The risk or severity of adverse effects can be increased when Farletuzumab is combined with Depatuxizumab mafodotin.
Veltuzumab The risk or severity of adverse effects can be increased when Veltuzumab is combined with Depatuxizumab mafodotin.
Ustekinumab The risk or severity of adverse effects can be increased when Ustekinumab is combined with Depatuxizumab mafodotin.
Trastuzumab emtansine The risk or severity of adverse effects can be increased when Trastuzumab emtansine is combined with Depatuxizumab mafodotin.
PRO-542 The risk or severity of adverse effects can be increased when PRO-542 is combined with Depatuxizumab mafodotin.
TNX-901 The risk or severity of adverse effects can be increased when TNX-901 is combined with Depatuxizumab mafodotin.
Inotuzumab ozogamicin The risk or severity of adverse effects can be increased when Inotuzumab ozogamicin is combined with Depatuxizumab mafodotin.
RI 624 The risk or severity of adverse effects can be increased when RI 624 is combined with Depatuxizumab mafodotin.
Stamulumab The risk or severity of adverse effects can be increased when MYO-029 is combined with Depatuxizumab mafodotin.
CT-011 The risk or severity of adverse effects can be increased when CT-011 is combined with Depatuxizumab mafodotin.
Leronlimab The risk or severity of adverse effects can be increased when Leronlimab is combined with Depatuxizumab mafodotin.
Glembatumumab vedotin The risk or severity of adverse effects can be increased when Glembatumumab vedotin is combined with Depatuxizumab mafodotin.
Olaratumab The risk or severity of adverse effects can be increased when Olaratumab is combined with Depatuxizumab mafodotin.
IPH 2101 The risk or severity of adverse effects can be increased when IPH 2101 is combined with Depatuxizumab mafodotin.
TB-402 The risk or severity of adverse effects can be increased when TB-402 is combined with Depatuxizumab mafodotin.
Caplacizumab The risk or severity of adverse effects can be increased when Caplacizumab is combined with Depatuxizumab mafodotin.
IMC-1C11 The risk or severity of adverse effects can be increased when IMC-1C11 is combined with Depatuxizumab mafodotin.
Eldelumab The risk or severity of adverse effects can be increased when Eldelumab is combined with Depatuxizumab mafodotin.
Lumiliximab The risk or severity of adverse effects can be increased when Lumiliximab is combined with Depatuxizumab mafodotin.

Target Protein

Tubulin beta chain TUBB
Epidermal growth factor receptor EGFR
B-lymphocyte antigen CD19 CD19

Referensi & Sumber

Artikel (PubMed)
  • PMID: 26846818
    Phillips AC, Boghaert ER, Vaidya KS, Mitten MJ, Norvell S, Falls HD, DeVries PJ, Cheng D, Meulbroek JA, Buchanan FG, McKay LM, Goodwin NC, Reilly EB: ABT-414, an Antibody-Drug Conjugate Targeting a Tumor-Selective EGFR Epitope. Mol Cancer Ther. 2016 Apr;15(4):661-9. doi: 10.1158/1535-7163.MCT-15-0901. Epub 2016 Feb 4.
  • PMID: 27518442
    Waight AB, Bargsten K, Doronina S, Steinmetz MO, Sussman D, Prota AE: Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics. PLoS One. 2016 Aug 12;11(8):e0160890. doi: 10.1371/journal.pone.0160890. eCollection 2016.
  • PMID: 2211617
    Bai RL, Pettit GR, Hamel E: Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites. J Biol Chem. 1990 Oct 5;265(28):17141-9.

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Sekuens Gen/Protein (FASTA)

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