Dutogliptin

DB11723

small molecule investigational

Deskripsi

Dutogliptin has been investigated for the treatment of Diabetes Mellitus, Type II.

Struktur Molekul 2D

Berat 241.1
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 10-13 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

650 Data
Pegvisomant The risk or severity of hypoglycemia can be increased when Pegvisomant is combined with Dutogliptin.
Lipoic acid The risk or severity of hypoglycemia can be increased when Lipoic acid is combined with Dutogliptin.
Moxifloxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Moxifloxacin.
Grepafloxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Grepafloxacin.
Enoxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Enoxacin.
Pefloxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Pefloxacin.
Ciprofloxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Ciprofloxacin.
Trovafloxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Trovafloxacin.
Nalidixic acid The therapeutic efficacy of Dutogliptin can be increased when used in combination with Nalidixic acid.
Rosoxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Rosoxacin.
Cinoxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Cinoxacin.
Lomefloxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Lomefloxacin.
Gatifloxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Gatifloxacin.
Norfloxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Norfloxacin.
Levofloxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Levofloxacin.
Gemifloxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Gemifloxacin.
Ofloxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Ofloxacin.
Sparfloxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Sparfloxacin.
Temafloxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Temafloxacin.
Fleroxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Fleroxacin.
Technetium Tc-99m ciprofloxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Technetium Tc-99m ciprofloxacin.
Garenoxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Garenoxacin.
Nemonoxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Nemonoxacin.
Flumequine The therapeutic efficacy of Dutogliptin can be increased when used in combination with Flumequine.
Enrofloxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Enrofloxacin.
Orbifloxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Orbifloxacin.
Sarafloxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Sarafloxacin.
Difloxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Difloxacin.
Pazufloxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Pazufloxacin.
Prulifloxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Prulifloxacin.
Delafloxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Delafloxacin.
Sitafloxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Sitafloxacin.
Oxolinic acid The therapeutic efficacy of Dutogliptin can be increased when used in combination with Oxolinic acid.
Rufloxacin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Rufloxacin.
Pipemidic acid The therapeutic efficacy of Dutogliptin can be increased when used in combination with Pipemidic acid.
Methyclothiazide The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Methyclothiazide.
Chlorthalidone The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Chlorthalidone.
Bendroflumethiazide The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Bendroflumethiazide.
Metolazone The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Metolazone.
Benzthiazide The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Benzthiazide.
Hydroflumethiazide The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Hydroflumethiazide.
Indapamide The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Indapamide.
Chlorothiazide The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Chlorothiazide.
Hydrochlorothiazide The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Hydrochlorothiazide.
Trichlormethiazide The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Trichlormethiazide.
Polythiazide The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Polythiazide.
Quinethazone The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Quinethazone.
Cyclopenthiazide The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Cyclopenthiazide.
Epitizide The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Epitizide.
Amitriptyline Amitriptyline may decrease the hypoglycemic activities of Dutogliptin.
Protriptyline Protriptyline may decrease the hypoglycemic activities of Dutogliptin.
Imipramine Imipramine may decrease the hypoglycemic activities of Dutogliptin.
Nortriptyline Nortriptyline may decrease the hypoglycemic activities of Dutogliptin.
Amoxapine Amoxapine may decrease the hypoglycemic activities of Dutogliptin.
Trimipramine Trimipramine may decrease the hypoglycemic activities of Dutogliptin.
Doxepin Doxepin may decrease the hypoglycemic activities of Dutogliptin.
Desipramine Desipramine may decrease the hypoglycemic activities of Dutogliptin.
Clomipramine Clomipramine may decrease the hypoglycemic activities of Dutogliptin.
Amineptine Amineptine may decrease the hypoglycemic activities of Dutogliptin.
Dimetacrine Dimetacrine may decrease the hypoglycemic activities of Dutogliptin.
Butriptyline Butriptyline may decrease the hypoglycemic activities of Dutogliptin.
Dosulepin Dosulepin may decrease the hypoglycemic activities of Dutogliptin.
Tianeptine Tianeptine may decrease the hypoglycemic activities of Dutogliptin.
Oxaprotiline Oxaprotiline may decrease the hypoglycemic activities of Dutogliptin.
Opipramol Opipramol may decrease the hypoglycemic activities of Dutogliptin.
Amitriptylinoxide Amitriptylinoxide may decrease the hypoglycemic activities of Dutogliptin.
Dibenzepin Dibenzepin may decrease the hypoglycemic activities of Dutogliptin.
Quinupramine Quinupramine may decrease the hypoglycemic activities of Dutogliptin.
Melitracen Melitracen may decrease the hypoglycemic activities of Dutogliptin.
Lofepramine Lofepramine may decrease the hypoglycemic activities of Dutogliptin.
Iprindole Iprindole may decrease the hypoglycemic activities of Dutogliptin.
Imipramine oxide Imipramine oxide may decrease the hypoglycemic activities of Dutogliptin.
Glimepiride Dutogliptin may increase the hypoglycemic activities of Glimepiride.
Acetohexamide Dutogliptin may increase the hypoglycemic activities of Acetohexamide.
Chlorpropamide Dutogliptin may increase the hypoglycemic activities of Chlorpropamide.
Tolazamide Dutogliptin may increase the hypoglycemic activities of Tolazamide.
Glyburide Dutogliptin may increase the hypoglycemic activities of Glyburide.
Glipizide Dutogliptin may increase the hypoglycemic activities of Glipizide.
Gliclazide Dutogliptin may increase the hypoglycemic activities of Gliclazide.
Tolbutamide Dutogliptin may increase the hypoglycemic activities of Tolbutamide.
Gliquidone Dutogliptin may increase the hypoglycemic activities of Gliquidone.
Glisoxepide Dutogliptin may increase the hypoglycemic activities of Glisoxepide.
Glibornuride Dutogliptin may increase the hypoglycemic activities of Glibornuride.
Carbutamide Dutogliptin may increase the hypoglycemic activities of Carbutamide.
Metahexamide Dutogliptin may increase the hypoglycemic activities of Metahexamide.
Dapagliflozin Dapagliflozin may increase the hypoglycemic activities of Dutogliptin.
Canagliflozin Canagliflozin may increase the hypoglycemic activities of Dutogliptin.
Leuprolide The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Leuprolide.
Goserelin The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Goserelin.
Nelfinavir The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Nelfinavir.
Indinavir The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Indinavir.
Ziprasidone The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Ziprasidone.
Etonogestrel The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Etonogestrel.
Desogestrel The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Desogestrel.
Olanzapine The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Olanzapine.
Megestrol acetate The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Megestrol acetate.
Clozapine The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Clozapine.
Levonorgestrel The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Levonorgestrel.
Progesterone The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Progesterone.
Chlorpromazine The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Chlorpromazine.

Target Protein

Dipeptidyl peptidase 4 DPP4

Referensi & Sumber

Artikel (PubMed)
  • PMID: 17919550
    O'Farrell AM, van Vliet A, Abou Farha K, Cherrington JM, Campbell DA, Li X, Hanway D, Li J, Guler HP: Pharmacokinetic and pharmacodynamic assessments of the dipeptidyl peptidase-4 inhibitor PHX1149: double-blind, placebo-controlled, single- and multiple-dose studies in healthy subjects. Clin Ther. 2007 Aug;29(8):1692-705.

Contoh Produk & Brand

Produk: 0 • International brands: 0
Belum ada data produk/brand untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field produk/brand.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul