LD50: 265 mg/kg (Rat, oral).
Tropisetron is an indole derivative with antiemetic activity. As a selective serotonin receptor antagonist, tropisetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting.
Tropisetron appears to be well tolerated with the most frequently reported adverse effect being headache. Extrapyramidal side effects are rare upon using tropisetron.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Buprenorphine | Tropisetron may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. |
| Doxylamine | Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Tropisetron. |
| Dronabinol | Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Tropisetron. |
| Droperidol | Droperidol may increase the central nervous system depressant (CNS depressant) activities of Tropisetron. |
| Hydrocodone | Tropisetron may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. |
| Hydroxyzine | Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Tropisetron. |
| Magnesium sulfate | The therapeutic efficacy of Tropisetron can be increased when used in combination with Magnesium sulfate. |
| Methotrimeprazine | Tropisetron may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. |
| Metyrosine | Tropisetron may increase the sedative activities of Metyrosine. |
| Minocycline | Minocycline may increase the central nervous system depressant (CNS depressant) activities of Tropisetron. |
| Mirtazapine | Tropisetron may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine. |
| Nabilone | Nabilone may increase the central nervous system depressant (CNS depressant) activities of Tropisetron. |
| Orphenadrine | Tropisetron may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Paraldehyde | Tropisetron may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. |
| Perampanel | Perampanel may increase the central nervous system depressant (CNS depressant) activities of Tropisetron. |
| Pramipexole | Tropisetron may increase the sedative activities of Pramipexole. |
| Ropinirole | Tropisetron may increase the sedative activities of Ropinirole. |
| Rotigotine | Tropisetron may increase the sedative activities of Rotigotine. |
| Rufinamide | The risk or severity of adverse effects can be increased when Rufinamide is combined with Tropisetron. |
| Sodium oxybate | Tropisetron may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate. |
| Suvorexant | Tropisetron may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Tapentadol | Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Tropisetron. |
| Thalidomide | Tropisetron may increase the central nervous system depressant (CNS depressant) activities of Thalidomide. |
| Zolpidem | Tropisetron may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. |
| Methadone | The risk or severity of adverse effects can be increased when Methadone is combined with Tropisetron. |
| Dicoumarol | The risk or severity of adverse effects can be increased when Tropisetron is combined with Dicoumarol. |
| Phenindione | The risk or severity of adverse effects can be increased when Tropisetron is combined with Phenindione. |
| Phenprocoumon | The risk or severity of adverse effects can be increased when Tropisetron is combined with Phenprocoumon. |
| Acenocoumarol | The risk or severity of adverse effects can be increased when Tropisetron is combined with Acenocoumarol. |
| 4-hydroxycoumarin | The risk or severity of adverse effects can be increased when Tropisetron is combined with 4-hydroxycoumarin. |
| Coumarin | The risk or severity of adverse effects can be increased when Tropisetron is combined with Coumarin. |
| (R)-warfarin | The risk or severity of adverse effects can be increased when Tropisetron is combined with (R)-warfarin. |
| Ethyl biscoumacetate | The risk or severity of adverse effects can be increased when Tropisetron is combined with Ethyl biscoumacetate. |
| Fluindione | The risk or severity of adverse effects can be increased when Tropisetron is combined with Fluindione. |
| Clorindione | The risk or severity of adverse effects can be increased when Tropisetron is combined with Clorindione. |
| Diphenadione | The risk or severity of adverse effects can be increased when Tropisetron is combined with Diphenadione. |
| Tioclomarol | The risk or severity of adverse effects can be increased when Tropisetron is combined with Tioclomarol. |
| (S)-Warfarin | The risk or severity of adverse effects can be increased when Tropisetron is combined with (S)-Warfarin. |
| Ethanol | Tropisetron may increase the central nervous system depressant (CNS depressant) activities of Ethanol. |
| Azelastine | Tropisetron may increase the central nervous system depressant (CNS depressant) activities of Azelastine. |
| Brimonidine | Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Tropisetron. |
| Fluvoxamine | The risk or severity of adverse effects can be increased when Tropisetron is combined with Fluvoxamine. |
| Citalopram | The risk or severity of adverse effects can be increased when Tropisetron is combined with Citalopram. |
| Duloxetine | The risk or severity of adverse effects can be increased when Tropisetron is combined with Duloxetine. |
| Trazodone | The risk or severity of adverse effects can be increased when Tropisetron is combined with Trazodone. |
| Paroxetine | The risk or severity of adverse effects can be increased when Tropisetron is combined with Paroxetine. |
| Sertraline | The risk or severity of adverse effects can be increased when Tropisetron is combined with Sertraline. |
| Sibutramine | The risk or severity of adverse effects can be increased when Tropisetron is combined with Sibutramine. |
| Nefazodone | The risk or severity of adverse effects can be increased when Tropisetron is combined with Nefazodone. |
| Escitalopram | The risk or severity of adverse effects can be increased when Tropisetron is combined with Escitalopram. |
| Zimelidine | The risk or severity of adverse effects can be increased when Tropisetron is combined with Zimelidine. |
| Dapoxetine | The risk or severity of adverse effects can be increased when Tropisetron is combined with Dapoxetine. |
| Milnacipran | The risk or severity of adverse effects can be increased when Tropisetron is combined with Milnacipran. |
| Desvenlafaxine | The risk or severity of adverse effects can be increased when Tropisetron is combined with Desvenlafaxine. |
| Seproxetine | The risk or severity of adverse effects can be increased when Tropisetron is combined with Seproxetine. |
| Levomilnacipran | Levomilnacipran may decrease the excretion rate of Tropisetron which could result in a higher serum level. |
| Indalpine | The risk or severity of adverse effects can be increased when Tropisetron is combined with Indalpine. |
| Ritanserin | The risk or severity of adverse effects can be increased when Tropisetron is combined with Ritanserin. |
| Alaproclate | The risk or severity of adverse effects can be increased when Tropisetron is combined with Alaproclate. |
| Esmolol | Esmolol may increase the arrhythmogenic activities of Tropisetron. |
| Betaxolol | Betaxolol may increase the arrhythmogenic activities of Tropisetron. |
| Dofetilide | Dofetilide may increase the arrhythmogenic activities of Tropisetron. |
| Lidocaine | Lidocaine may increase the arrhythmogenic activities of Tropisetron. |
| Atenolol | Atenolol may increase the arrhythmogenic activities of Tropisetron. |
| Diltiazem | Diltiazem may increase the arrhythmogenic activities of Tropisetron. |
| Mexiletine | Mexiletine may increase the arrhythmogenic activities of Tropisetron. |
| Amlodipine | Amlodipine may increase the arrhythmogenic activities of Tropisetron. |
| Nimodipine | Nimodipine may increase the arrhythmogenic activities of Tropisetron. |
| Sotalol | Sotalol may increase the arrhythmogenic activities of Tropisetron. |
| Acetyldigitoxin | Acetyldigitoxin may increase the arrhythmogenic activities of Tropisetron. |
| Lercanidipine | Lercanidipine may increase the arrhythmogenic activities of Tropisetron. |
| Cinnarizine | Cinnarizine may increase the arrhythmogenic activities of Tropisetron. |
| Adenosine | Adenosine may increase the arrhythmogenic activities of Tropisetron. |
| Losartan | Losartan may increase the arrhythmogenic activities of Tropisetron. |
| Levomenthol | Levomenthol may increase the arrhythmogenic activities of Tropisetron. |
| Loperamide | Loperamide may increase the arrhythmogenic activities of Tropisetron. |
| Levosimendan | Levosimendan may increase the arrhythmogenic activities of Tropisetron. |
| Felodipine | Felodipine may increase the arrhythmogenic activities of Tropisetron. |
| Nitrendipine | Nitrendipine may increase the arrhythmogenic activities of Tropisetron. |
| Tocainide | Tocainide may increase the arrhythmogenic activities of Tropisetron. |
| Perhexiline | Perhexiline may increase the arrhythmogenic activities of Tropisetron. |
| Deslanoside | Deslanoside may increase the arrhythmogenic activities of Tropisetron. |
| Carvedilol | Carvedilol may increase the arrhythmogenic activities of Tropisetron. |
| Bretylium | Bretylium may increase the arrhythmogenic activities of Tropisetron. |
| Propafenone | Propafenone may increase the arrhythmogenic activities of Tropisetron. |
| Acebutolol | Acebutolol may increase the arrhythmogenic activities of Tropisetron. |
| Flecainide | Flecainide may increase the arrhythmogenic activities of Tropisetron. |
| Encainide | Encainide may increase the arrhythmogenic activities of Tropisetron. |
| Bepridil | Bepridil may increase the arrhythmogenic activities of Tropisetron. |
| Practolol | Practolol may increase the arrhythmogenic activities of Tropisetron. |
| Mibefradil | Mibefradil may increase the arrhythmogenic activities of Tropisetron. |
| Digitoxin | Digitoxin may increase the arrhythmogenic activities of Tropisetron. |
| Ajmaline | Ajmaline may increase the arrhythmogenic activities of Tropisetron. |
| Aprindine | Aprindine may increase the arrhythmogenic activities of Tropisetron. |
| Dexpropranolol | Dexpropranolol may increase the arrhythmogenic activities of Tropisetron. |
| Prenylamine | Prenylamine may increase the arrhythmogenic activities of Tropisetron. |
| Cyclandelate | Cyclandelate may increase the arrhythmogenic activities of Tropisetron. |
| Celiprolol | Celiprolol may increase the arrhythmogenic activities of Tropisetron. |
| Dronedarone | Dronedarone may increase the arrhythmogenic activities of Tropisetron. |
| Nebivolol | Nebivolol may increase the arrhythmogenic activities of Tropisetron. |