Triheptanoin

DB11677

small molecule approved investigational

Deskripsi

Triheptanoin is a source of heptanoate fatty acids, which can be metabolized without the enzymes of long chain fatty acid oxidation.^L14612 In clinical trials, patients with long chain fatty acid oxidation disorders (lc-FAODs) treated with triheptanoin are less likely to develop hypoglycemia, cardiomyopathy, rhabdomyolysis, and hepatomegaly.A214812,A214817 Complications in lc-FAOD patients are reduced from approximately 60% to approximately 10% with the addition of triheptanoin.^A214817

Triheptanoin was granted FDA approval on 30 June 2020.^L14612

Struktur Molekul 2D

Berat 428.61

Wujud liquid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) Due to multiple peak concentrations of the heptanoate metabolite, the half life of triheptanoin could not be determined.[L14612]

Volume Distribusi -

Klirens (Clearance) A single dose of 0.3 g/kg results in a mean apparent clearance of 6.05 L/h/kg for heptanoate.[L14612] A single dose of 0.4 g/kg results in a mean apparent clearance of 4.31 L/h/kg for heptanoate.[L14612]

Absorpsi

A single 0.3 g/kg dose of triheptanoin reaches a C_max of 178.9 µmol/L, with a T_max 0.5 h, and an AUC of 336.5 µmol\*h/L.^L14612 A single 0.4 g/kg dose of triheptanoin reaches a C_max of 259.1 µmol/L, with a T_max 0.8 h, and an AUC of 569.1 µmol\*h/L.^L14612

Metabolisme

Triheptanoin is hydrolysed to heptanoate, which can be further metabolized to ?-hydroxypentanoate or ?-hydroxybutyrate.^L14612

Rute Eliminasi

Triheptanoin is minimally eliminated in the urine.^L14612

Interaksi Makanan

1 Data

1. Take with food. Take triheptanoin with food, liquid, or formula.

Interaksi Obat

1 Data

Orlistat

Orlistat can cause a decrease in the absorption of Triheptanoin resulting in a reduced serum concentration and potentially a decrease in efficacy.

Referensi & Sumber

Artikel (PubMed)

PMID: 31778232
Wehbe Z, Tucci S: Therapeutic potential of triheptanoin in metabolic and neurodegenerative diseases. J Inherit Metab Dis. 2020 May;43(3):385-391. doi: 10.1002/jimd.12199. Epub 2019 Dec 12.
PMID: 26547562
Roe CR, Brunengraber H: Anaplerotic treatment of long-chain fat oxidation disorders with triheptanoin: Review of 15 years Experience. Mol Genet Metab. 2015 Dec;116(4):260-8. doi: 10.1016/j.ymgme.2015.10.005. Epub 2015 Oct 24.
PMID: 19745557
van der Vusse GJ: Albumin as fatty acid transporter. Drug Metab Pharmacokinet. 2009;24(4):300-7. doi: 10.2133/dmpk.24.300.

Link

FDA Approved Drug Products: Dojolvi Triheptanoin Oral Liquid

Contoh Produk & Brand

Produk: 2 • International brands: 1

Produk

Dojolvi

Liquid • 100 % w/w • Oral • Canada • Approved
Dojolvi

Liquid • 0.96 g/1mL • Oral • US • Approved

International Brands

Dojolvi

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.