Many of gestrinone's adverse effects occur due to its androgenic activity. These effects include acne, seborrhea, hirsutism, weight gain and deepening of the voice. Most patients develop at least one adverse event while taking this drug. This is because the drug is embryotoxic in some animals and may also cause masculinization of a female fetus. Gestrinone significantly reduces HDL concentrations L1697.
It is advisable to monitor liver transaminases and cholesterol levels in hyperlipidemic patients, as well as glucose in diabetic patients. Gestrinone has shown to decrease in the concentration of thyroid-binding globulin. Therefore, a decrease in serum total thyroxine levels is commonly observed. This is without clinical significance as free thyroxine levels and thyroid-stimulating hormone levels remain within the normal reference range L1700.
Gestrinone, also known as ethylnorgestrienone, is a synthetic steroid of the 19-nortestosterone group that is marketed in Europe, Australia, and Latin America, though not the United States or Canada, and is used primarily in the treatment of endometriosis.
Gestrinone was developed in the early 1970s and was tested clinically as a weekly oral contraceptive in Europe and North America. Without significant advantages over other oral contraceptives and with its high cost, gestrinone was no longer used after the Stage II clinical trials. However, from 1982 this drug attracted increased interest due to significant therapeutic effects in the treatment endometriosis. Under different endocrine conditions, gestrinone possesses estrogenic, progestational, androgenic, antiestrogenic and antiprogesterone actions L1696.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Acitretin | The therapeutic efficacy of Gestrinone can be decreased when used in combination with Acitretin. |
| Aprepitant | The serum concentration of Gestrinone can be decreased when it is combined with Aprepitant. |
| Atazanavir | The serum concentration of Gestrinone can be increased when it is combined with Atazanavir. |
| Boceprevir | The serum concentration of Gestrinone can be increased when it is combined with Boceprevir. |
| Prucalopride | The serum concentration of Gestrinone can be decreased when it is combined with Prucalopride. |
| Sugammadex | The serum concentration of Gestrinone can be decreased when it is combined with Sugammadex. |
| Thalidomide | Gestrinone may increase the thrombogenic activities of Thalidomide. |
| Ulipristal | The therapeutic efficacy of Gestrinone can be decreased when used in combination with Ulipristal. |
| Ursodeoxycholic acid | The therapeutic efficacy of Ursodeoxycholic acid can be decreased when used in combination with Gestrinone. |
| Glycochenodeoxycholic Acid | The therapeutic efficacy of Glycochenodeoxycholic Acid can be decreased when used in combination with Gestrinone. |
| Cholic Acid | The therapeutic efficacy of Cholic Acid can be decreased when used in combination with Gestrinone. |
| Glycocholic acid | The therapeutic efficacy of Glycocholic acid can be decreased when used in combination with Gestrinone. |
| Deoxycholic acid | The therapeutic efficacy of Deoxycholic acid can be decreased when used in combination with Gestrinone. |
| Taurocholic acid | The therapeutic efficacy of Taurocholic acid can be decreased when used in combination with Gestrinone. |
| Obeticholic acid | The therapeutic efficacy of Obeticholic acid can be decreased when used in combination with Gestrinone. |
| Tauroursodeoxycholic acid | The therapeutic efficacy of Tauroursodeoxycholic acid can be decreased when used in combination with Gestrinone. |
| Bamet-UD2 | The therapeutic efficacy of Bamet-UD2 can be decreased when used in combination with Gestrinone. |
| cis-Diamminechlorocholylglycinateplatinum(II) | The therapeutic efficacy of cis-Diamminechlorocholylglycinateplatinum(II) can be decreased when used in combination with Gestrinone. |
| Dehydrocholic acid | The therapeutic efficacy of Dehydrocholic acid can be decreased when used in combination with Gestrinone. |
| Hyodeoxycholic Acid | The therapeutic efficacy of Hyodeoxycholic Acid can be decreased when used in combination with Gestrinone. |
| Aramchol | The therapeutic efficacy of Aramchol can be decreased when used in combination with Gestrinone. |
| Ox bile extract | The therapeutic efficacy of Ox bile extract can be decreased when used in combination with Gestrinone. |
| Chenodeoxycholic acid | The therapeutic efficacy of Chenodeoxycholic acid can be decreased when used in combination with Gestrinone. |
| Taurochenodeoxycholic acid | The therapeutic efficacy of Taurochenodeoxycholic acid can be decreased when used in combination with Gestrinone. |
| Capromab pendetide | Gestrinone may decrease effectiveness of Capromab pendetide as a diagnostic agent. |
| Tranexamic acid | Gestrinone may increase the thrombogenic activities of Tranexamic acid. |
| Clobazam | The serum concentration of Gestrinone can be decreased when it is combined with Clobazam. |
| Colestipol | Colestipol can cause a decrease in the absorption of Gestrinone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Sevelamer | Sevelamer can cause a decrease in the absorption of Gestrinone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Colesevelam | Colesevelam can cause a decrease in the absorption of Gestrinone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Cholestyramine | Cholestyramine can cause a decrease in the absorption of Gestrinone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Griseofulvin | The metabolism of Gestrinone can be increased when combined with Griseofulvin. |
| Tixocortol | The serum concentration of Tixocortol can be increased when it is combined with Gestrinone. |
| Fluocortin | The serum concentration of Fluocortin can be increased when it is combined with Gestrinone. |
| Fluperolone | The serum concentration of Fluperolone can be increased when it is combined with Gestrinone. |
| Fluclorolone | The serum concentration of Fluclorolone can be increased when it is combined with Gestrinone. |
| Flunisolide | The serum concentration of Flunisolide can be increased when it is combined with Gestrinone. |
| Beclomethasone dipropionate | The serum concentration of Beclomethasone dipropionate can be increased when it is combined with Gestrinone. |
| Betamethasone | The serum concentration of Betamethasone can be increased when it is combined with Gestrinone. |
| Fluocinolone acetonide | The serum concentration of Fluocinolone acetonide can be increased when it is combined with Gestrinone. |
| Triamcinolone | The serum concentration of Triamcinolone can be increased when it is combined with Gestrinone. |
| Prednisone | The serum concentration of Prednisone can be increased when it is combined with Gestrinone. |
| Hydrocortisone | The serum concentration of Hydrocortisone can be increased when it is combined with Gestrinone. |
| Prednisolone | The serum concentration of Prednisolone can be increased when it is combined with Gestrinone. |
| Methylprednisolone | The serum concentration of Methylprednisolone can be increased when it is combined with Gestrinone. |
| Corticotropin | The serum concentration of Corticotropin can be increased when it is combined with Gestrinone. |
| Cortisone acetate | The serum concentration of Cortisone acetate can be increased when it is combined with Gestrinone. |
| Fluprednidene | The serum concentration of Fluprednidene can be increased when it is combined with Gestrinone. |
| Meprednisone | The serum concentration of Meprednisone can be increased when it is combined with Gestrinone. |
| Dexamethasone isonicotinate | The serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Gestrinone. |
| Deflazacort | The serum concentration of Deflazacort can be increased when it is combined with Gestrinone. |
| Cortivazol | The serum concentration of Cortivazol can be increased when it is combined with Gestrinone. |
| Prednylidene | The serum concentration of Prednylidene can be increased when it is combined with Gestrinone. |
| Cloprednol | The serum concentration of Cloprednol can be increased when it is combined with Gestrinone. |
| Mometasone furoate | The serum concentration of Mometasone furoate can be increased when it is combined with Gestrinone. |
| Hydrocortisone acetate | The serum concentration of Hydrocortisone acetate can be increased when it is combined with Gestrinone. |
| Hydrocortisone succinate | The serum concentration of Hydrocortisone succinate can be increased when it is combined with Gestrinone. |
| Prednisolone phosphate | The serum concentration of Prednisolone phosphate can be increased when it is combined with Gestrinone. |
| Prednisolone hemisuccinate | The serum concentration of Prednisolone hemisuccinate can be increased when it is combined with Gestrinone. |
| Methylprednisolone hemisuccinate | The serum concentration of Methylprednisolone hemisuccinate can be increased when it is combined with Gestrinone. |
| Prednisone acetate | The serum concentration of Prednisone acetate can be increased when it is combined with Gestrinone. |
| Clocortolone acetate | The serum concentration of Clocortolone acetate can be increased when it is combined with Gestrinone. |
| Melengestrol acetate | The serum concentration of Melengestrol acetate can be increased when it is combined with Gestrinone. |
| Betamethasone phosphate | The serum concentration of Betamethasone phosphate can be increased when it is combined with Gestrinone. |
| Cortisone | The serum concentration of Cortisone can be increased when it is combined with Gestrinone. |
| Fluticasone propionate | The serum concentration of Fluticasone propionate can be increased when it is combined with Gestrinone. |
| Fludrocortisone | The serum concentration of Fludrocortisone can be increased when it is combined with Gestrinone. |
| Trilostane | The serum concentration of Trilostane can be increased when it is combined with Gestrinone. |
| Budesonide | The serum concentration of Budesonide can be increased when it is combined with Gestrinone. |
| Dexamethasone | The serum concentration of Dexamethasone can be increased when it is combined with Gestrinone. |
| Paramethasone | The serum concentration of Paramethasone can be increased when it is combined with Gestrinone. |
| Ciclesonide | The serum concentration of Ciclesonide can be increased when it is combined with Gestrinone. |
| Aldosterone | The serum concentration of Aldosterone can be increased when it is combined with Gestrinone. |
| Fluticasone furoate | The serum concentration of Fluticasone furoate can be increased when it is combined with Gestrinone. |
| Fluprednisolone | The serum concentration of Fluprednisolone can be increased when it is combined with Gestrinone. |
| Melengestrol | The serum concentration of Melengestrol can be increased when it is combined with Gestrinone. |
| Fluticasone | The serum concentration of Fluticasone can be increased when it is combined with Gestrinone. |
| Hydrocortisone cypionate | The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Gestrinone. |
| Clobetasol propionate | The serum concentration of Clobetasol propionate can be increased when it is combined with Gestrinone. |
| Fluocinonide | The serum concentration of Fluocinonide can be increased when it is combined with Gestrinone. |
| Hydrocortisone butyrate | The serum concentration of Hydrocortisone butyrate can be increased when it is combined with Gestrinone. |
| Desoximetasone | The serum concentration of Desoximetasone can be increased when it is combined with Gestrinone. |
| Mometasone | The serum concentration of Mometasone can be increased when it is combined with Gestrinone. |
| Fluocortolone | The serum concentration of Fluocortolone can be increased when it is combined with Gestrinone. |
| Prednisolone acetate | The serum concentration of Prednisolone acetate can be increased when it is combined with Gestrinone. |
| Fluorometholone | The serum concentration of Fluorometholone can be increased when it is combined with Gestrinone. |
| Difluocortolone | The serum concentration of Difluocortolone can be increased when it is combined with Gestrinone. |
| Flumethasone | The serum concentration of Flumethasone can be increased when it is combined with Gestrinone. |
| Methylprednisolone aceponate | The serum concentration of Methylprednisolone aceponate can be increased when it is combined with Gestrinone. |
| Vitamin A | The therapeutic efficacy of Gestrinone can be decreased when used in combination with Vitamin A. |
| Bexarotene | The therapeutic efficacy of Gestrinone can be decreased when used in combination with Bexarotene. |
| Alitretinoin | The therapeutic efficacy of Gestrinone can be decreased when used in combination with Alitretinoin. |
| Tretinoin | The therapeutic efficacy of Gestrinone can be decreased when used in combination with Tretinoin. |
| Tazarotene | The therapeutic efficacy of Gestrinone can be decreased when used in combination with Tazarotene. |
| Etretinate | The therapeutic efficacy of Gestrinone can be decreased when used in combination with Etretinate. |
| Isotretinoin | The therapeutic efficacy of Gestrinone can be decreased when used in combination with Isotretinoin. |
| 4-Oxoretinol | The therapeutic efficacy of Gestrinone can be decreased when used in combination with 4-Oxoretinol. |
| Fenretinide | The therapeutic efficacy of Gestrinone can be decreased when used in combination with Fenretinide. |
| Ro 12-7310 | The therapeutic efficacy of Gestrinone can be decreased when used in combination with Ro 12-7310. |
| Zuretinol acetate | The therapeutic efficacy of Gestrinone can be decreased when used in combination with Zuretinol acetate. |